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Accepted manuscript

Investigation of leptin and leptin receptor gene polymorphisms in schizophrenia: further support for an association with attempted suicide

Published online by Cambridge University Press:  10 February 2026

Hasan Mervan AYTAC Open the ORCID record for Hasan Mervan AYTAC [Opens in a new window] ,
Yasemin OYACI ,
Eren AYTAC ,
Mustafa PEHLIVAN ,
Huseyin Sehit BURHAN ,
Furkan Bahadir ALPTEKIN  and
Sacide PEHLIVAN
Hasan Mervan AYTAC*
Affiliation:
Institute of Graduate Studies in Health Sciences, Istanbul University, Istanbul, Turkey Department of Psychiatry, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey,
Yasemin OYACI
Affiliation:
Institute of Graduate Studies in Health Sciences, Istanbul University, Istanbul, Turkey Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University, Turkey
Eren AYTAC
Affiliation:
Department of Psychiatry, Konya Beyhekim Training and Research Hospital, Konya
Mustafa PEHLIVAN
Affiliation:
Department of Hematology, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey
Huseyin Sehit BURHAN
Affiliation:
Department of Psychiatry, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey,
Furkan Bahadir ALPTEKIN
Affiliation:
Department of Psychiatry, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey,
Sacide PEHLIVAN
Affiliation:
Institute of Graduate Studies in Health Sciences, Istanbul University, Istanbul, Turkey Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University, Turkey
*
Corresponding Author: Hasan Mervan, mervan176@hotmail.com
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Abstract

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Objective:

This study aimed to investigate leptin (LEP) (G-2548A) and leptin receptor (LEPR) (668A>G) gene polymorphisms in SCZ patients with and without suicide attempts, compared to controls

Methods:

The study included 120 patients with SCZ and 130 healthy volunteers. Sociodemographic characteristics, suicidal behavior, and symptom severity were assessed using data collection forms. Gene polymorphisms were analyzed from DNA samples using the polymerase chain reaction–restriction fragment length polymorphism.

Results:

The LEP genotype distribution in SCZ patients differed significantly from controls, with the heterozygous GA genotype more frequent in controls (p = .026). Within SCZ, LEPR genotype distribution differed by suicide attempt history; the heterozygous AG genotype was more frequent in non-attempters (p = .048). Logistic regression showed that the LEPR polymorphism (p = .023), number of hospitalizations (p = .036), and PANSS-psychopathology score (p = .023) predict suicide attempt history in SCZ.

Conclusion:

Our findings suggest that LEP polymorphism may contribute to SCZ susceptibility, while LEPR polymorphism may be linked to suicide attempts in SCZ.

Keywords

Schizophrenialeptinleptin receptorsingle nucleotide polymorphismsuicide attempt

Information

Type
Original Article
Information
Acta Neuropsychiatrica , Accepted manuscript , pp. 1 - 27
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
Copyright
© The Author(s), 2026. Published by Cambridge University Press on behalf of Scandinavian College of Neuropsychopharmacology