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Should It Be a Contraindication for Drugs Like Lecanemab?
Published online by Cambridge University Press: 19 January 2024
CAA is vascular disease of the brain in which beta-amyloid is deposited in the walls of small arteries and capillaries. The amyloid replaces smooth muscle cells, causing vessel wall thickening and stiffness. This can result in leaks and reduced blood flow in these small blood vessels. Tiny hemorrhages and small strokes are seen surrounding the affected blood vessels. In the elderly, CAA is a major cause of serious bleeding in the various lobes of the brain. Genetically, it can occur sporadically or in families. There is often but not always an overlap with Alzheimer’s disease.
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