We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
From Biogenesis to Extinction
Published online by Cambridge University Press: 14 June 2024
This chapter covers the complete life cycle of microRNAs, from start to finish. Beginning with their location in the genome, how they are transcribed and some of the factors that switch microRNAs on and off, it moves next to the biochemical steps involved in the step-wise processing of the precursor RNA by the enzymes Drosha and Dicer, before the microRNA is eventually loaded into a pocket in the Argonaute protein ready to carry out gene silencing. For some steps, a deeper look is taken into the atomic structures of these biological nanomachines and how they pivot and adjust to join together proteins and RNA as they perform their functions. This includes the remarkable search strategy by which the gene silencing complex containing a microRNA probes for binding sites on mRNA targets. Finally comes the molecular decision-making behind how much protein is reduced and by what mechanism. The when and how a microRNA knows its work is done and what finally extinguishes its effects. Again, the chapter conveys the intense competition among scientists vying to answer the next question and the one after that, which was a potent accelerant for discovery.
To save this book to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Find out more about the Kindle Personal Document Service.
To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.
To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.
