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Chapter 25 - Analysis of embryo-derived factors as markers of developmental potential and viability

Published online by Cambridge University Press:  16 May 2011

By
Chris O’Neill
Edited by
David K. Gardner ,
Botros R. M. B. Rizk  and
Tommaso Falcone
David K. Gardner
Affiliation:
University of Melbourne
Botros R. M. B. Rizk
Affiliation:
University of South Alabama
Tommaso Falcone
Affiliation:
Cleveland Clinic Foundation
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Summary

This chapter focuses on the embryo's bioactive secretome. It provides a brief overview of the early developments in the field, an analysis of the current state of development of diagnostic markers for embryo development and discusses the limitations in their development. There is an active bi-directional dialog between the embryo and the female reproductive tract which commences soon after fertilization. Embryo-derived potent platelet-activating factor (Paf) was capable of inducing a transient thrombocytopenia in peripheral blood within hours of fertilization in a range of species, and also sometimes caused a rebound thrombocytosis. Paf acts on a membrane receptor as early as the zygote stage to induce characteristic transient increases in the embryo's cytoplasmic calcium concentration. The chapter also provides a personal perspective of the future challenges to development and considers the broader benefits and risks that may accrue from a detailed analysis of the embryo's secretome.

Keywords

conventional IVFembryo development ratesfollicle stimulating hormoneinfertility treatmentin vitro fertilizationhuman oocyte in vitro maturation
Type
Chapter
Information
Human Assisted Reproductive Technology
Future Trends in Laboratory and Clinical Practice
 , pp. 278 - 288
Publisher: Cambridge University Press
Print publication year: 2011

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