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Chapter 14 - Early life stress and psychiatric risk/resilience: the importance of a developmental neurobiological model in understanding gene by environment interactions

from Section 2 - Biological approaches to early life trauma

Published online by Cambridge University Press:  03 May 2011

By
Skelton Kelly ,
Weiss Tamara  and
Bekh Bradley
Edited by
Ruth A. Lanius ,
Eric Vermetten  and
Clare Pain
Ruth A. Lanius
Affiliation:
University of Western Ontario
Eric Vermetten
Affiliation:
Universiteit Utrecht, The Netherlands
Clare Pain
Affiliation:
University of Toronto
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Summary

Early life stress (ELS) and abuse are the most commonly assessed environmental exposures in psychiatric genes and environment (GxE) interaction studies, partly because of the strength of evidence that ELS plays a role in risk for multiple psychiatric disorders. The research on GxE interactions is organized by the presumed underlying neurobiological systems and by the broader classification of psychiatric outcomes (mood/anxiety disorders and externalizing disorders). This chapter discusses the importance of clearly defining and measuring both the proposed environmental risk/resilience factors as well as the predicted diagnostic and behavioral outcomes. This allows investigators to conduct GxE studies that better inform the understanding of the role of ELS in predicting psychiatric risk/resilience. The chapter focuses on childhood physical, sexual and emotional abuse, which is currently among the most well-researched environmental risk variables in human psychopathology research.
Type
Chapter
Information
The Impact of Early Life Trauma on Health and Disease
The Hidden Epidemic
 , pp. 148 - 156
Publisher: Cambridge University Press
Print publication year: 2010

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