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Chapter 10 - Alloimmunization

from Section 1 - Obstetric Aspects of Antenatal Care

Published online by Cambridge University Press:  23 February 2023

Amira El-Messidi
Affiliation:
McGill University, Montréal
Alan D. Cameron
Affiliation:
University of Glasgow
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Summary

A new patient presents for consultation and transfer of care to your high-risk obstetrics unit at a tertiary center. She is a 34-year-old G4P2A1L2 at 14+3 weeks’ gestation with anti-c antibodies detected on routine testing; results have been confirmed at your hospital’s laboratory. All other prenatal investigations are unremarkable, including first-trimester sonogram and aneuploidy risk assessment.

Type
Chapter
Information
OSCEs in Obstetrics and Maternal-Fetal Medicine
An Evidence-Based Approach
, pp. 127 - 140
Publisher: Cambridge University Press
Print publication year: 2023

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References

Suggested Readings

Brennand, J, Cameron, A. Fetal anaemia: diagnosis and management. Best Pract Res Clin Obstet Gynaecol. 2008;22(1):1529.Google Scholar
Castleman, JS, Kilby, MD. Red cell alloimmunization: a 2020 update. Prenat Diagn. 2020;40(9):10991108.CrossRefGoogle ScholarPubMed
The management of women with red cell antibodies during pregnancy. Green Top Guideline number 65, 2014. Available at www.rcog.org.uk/en/guidelines-research-services/guidelines/gtg65. Accessed February 22, 2021.Google Scholar
Koelewijn, JM, Vrijkotte, TG, de Haas, M, et al. Risk factors for the presence of non-rhesus D red blood cell antibodies in pregnancy. BJOG. 2009;116(5):655664.Google Scholar
Moise, KJ Jr, Argoti, PS. Management and prevention of red cell alloimmunization in pregnancy: a systematic review. Obstet Gynecol. 2012;120(5):11321139.CrossRefGoogle ScholarPubMed
Scottish National Clinical Guidance: Pregnant women with red cell antibodies, version 2, July 2013. Available at https://nhsnss.org/services/blood-tissues-and-cells/clinical-services/information-and-manuals-for-clinicians/. Accessed February 22, 2021.Google Scholar
Society for Maternal-Fetal Medicine, Mari, G, Norton, ME, et al. Society for Maternal-Fetal Medicine (SMFM) Clinical Guideline No. 8: the fetus at risk for anemia – diagnosis and management. Am J Obstet Gynecol. 2015;212(6):697710.CrossRefGoogle Scholar
Webb, J, Delaney, M. Red blood cell alloimmunization in the pregnant patient. Transfus Med Rev. 2018;32(4):213219.Google Scholar
White, J, Qureshi, H, Massey, E, et al. Guideline for blood grouping and red cell antibody testing in pregnancy. Transfus Med. 2016;26(4):246263.CrossRefGoogle ScholarPubMed
Zwiers, C, van Kamp, IL, Oepkes, D. Management of red cell alloimmunization. Chapter 10 in: Kilby, MD, Johnson, A, Oepkes, D, eds., Fetal Therapy: Scientific Basis and Critical Appraisal of Clinical Benefits, 2nd ed. Cambridge: Cambridge University Press; 2020.Google Scholar

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