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Chapter 10 - Multiple sclerosis

Published online by Cambridge University Press:  05 July 2012

By
Alfred W. Sandrock  and
Richard A. Rudick
Edited by
James E. Barrett ,
Joseph T. Coyle  and
Michael Williams
James E. Barrett
Affiliation:
Drexel University, Philadelphia
Joseph T. Coyle
Affiliation:
Harvard University School of Medicine, Massachusetts
Michael Williams
Affiliation:
Drexel University, Philadelphia
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Summary

Translational medicine is beginning to be successfully applied in multiple sclerosis (MS). This chapter reviews how advances in our understanding of MS and our ability to measure MS are contributing to the application of translational medicine in this disorder. It presents a historical perspective on the evolution of disease-modifying treatments, and then proceeds to provide a discussion on molecular pathophysiology. Next, the factors that contribute to the efficiency of translational medicine are explained. Lastly, the future of disease-modifying therapies is discussed. Interferon beta (IFNβ) was the first effective disease-modifying therapy to become available for MS. The factors that improve the efficiency of translational medicine in MS include: the identification of drug targets within well-validated biological pathways; and the use of pharmacodynamic markers, especially in early proof-of-concept and dose-ranging clinical trials. The continuing accumulation of knowledge and understanding of MS can help to accelerate the developing novel therapies for MS.

Keywords

anxiety disorderglucocorticoidglucocorticoidspropranololmemoriesposttraumatic stress disorder
Type
Chapter
Information
Translational Neuroscience
Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders
 , pp. 178 - 196
Publisher: Cambridge University Press
Print publication year: 2012

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