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Event-related potentials and white matter lesions in bipolar disorder

Published online by Cambridge University Press:  24 June 2014

E. F. P. M. Vuurman ,
A. Honig ,
T. H. Lamers ,
J. Wiersma ,
L. Krabbendam ,
P. A. M. Hofman ,
W. A. Nolen  and
J. Jolles
E. F. P. M. Vuurman*
Affiliation:
Universiteit Maastricht, Department of Neuropsychology
A. Honig
Affiliation:
Academisch Ziekenhuis Maastricht, Department of Psychiatry
T. H. Lamers
Affiliation:
Academisch Ziekenhuis Maastricht, Department of Psychiatry
J. Wiersma
Affiliation:
Universiteit Maastricht, Department of Neuropsychology
L. Krabbendam
Affiliation:
Universiteit Maastricht, Department of Neuropsychology
P. A. M. Hofman
Affiliation:
Academisch Ziekenhuis Maastricht, Department of Radiology
W. A. Nolen
Affiliation:
Academisch Ziekenhuis Utrecht, Department of Psychiatry
J. Jolles
Affiliation:
Universiteit Maastricht, Department of Neuropsychology
*
EFPM Vuurman, Institute of Brain and Behavior, University of Maastricht, Postbus 616, 6200 MD Maastricht, the Netherlands. Tel: +31 433881046; Fax: +31 433884092; E-mail: e.vuurman@np.unimaas.nl
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Abstract

Objectives:

To investigate neurophysiological parameters which possibly distinguish subtypes I and II of patients with a bipolar disorder, and contrast the findings with observations from a group of schizophrenic patients and a group of healthy controls.

Methods:

Sixty-six volunteers underwent a MRI scan to determine the number and location of white matter lesions (WSL). A electrophysiological registration was made while all volunteers performed a auditory ‘oddball’ task, and the amplitude of the resulting P300 wave was compared.

Results:

Earlier reports of higher numbers of WSL in bipolar disorder were not replicated in this study. Subtypes I and II showed a different P300 amplitude and subtype I resembled the results of the schizophrenia group.

Conclusion:

Bipolar patients in remission have a functional brain disorder that is expressed by a change in physiological response to external stimuli.

Keywords

bipolar disorderP300white matter lesions
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 14 , Issue 1 , February 2002 , pp. 11 - 16
Copyright
Copyright © Acta Neuropsychiatrica 2002 

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