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Functional impairment and previous suicide attempts in bipolar disorder

Published online by Cambridge University Press:  24 June 2014

Adriane R. Rosa ,
Carolina Franco ,
Anabel Martínez-Aran ,
Jose Sánchez-Moreno ,
Manel Salamero ,
M. Valenti ,
Rafael Tabarés-Seisdedos ,
Ana González-Pinto ,
Flávio Kapczinski  and
Eduard Vieta
Adriane R. Rosa
Affiliation:
Bípolar Disorders Program, Molecular Psychiatry Laboratory, Hospital de Clinicas de Porto Alegre, Ramiro Barcelos, Porto Alegre, RS, Brazil Bipolar Disorders Program, Clinical Institute of Neuroscience, Hospital Clinic of Barcelona, CIBERSAM, Villarroel, Barcelona, Spain
Carolina Franco
Affiliation:
Bipolar Disorders Program, Clinical Institute of Neuroscience, Hospital Clinic of Barcelona, CIBERSAM, Villarroel, Barcelona, Spain Department of Psychiatry, Hospital General Universitario Gregorio Marañón, CIBERSAM, Madrid, Spain
Anabel Martínez-Aran
Affiliation:
Bipolar Disorders Program, Clinical Institute of Neuroscience, Hospital Clinic of Barcelona, CIBERSAM, Villarroel, Barcelona, Spain
Jose Sánchez-Moreno
Affiliation:
Bipolar Disorders Program, Clinical Institute of Neuroscience, Hospital Clinic of Barcelona, CIBERSAM, Villarroel, Barcelona, Spain Department of Psychiatry, Universidad Autonoma de Madrid Hospital, Universitario de la Princesa, CIBERSAM, Madrid, Spain
Manel Salamero
Affiliation:
Bipolar Disorders Program, Clinical Institute of Neuroscience, Hospital Clinic of Barcelona, CIBERSAM, Villarroel, Barcelona, Spain
M. Valenti
Affiliation:
Bipolar Disorders Program, Clinical Institute of Neuroscience, Hospital Clinic of Barcelona, CIBERSAM, Villarroel, Barcelona, Spain
Rafael Tabarés-Seisdedos
Affiliation:
Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, CIBERSAM, Spain
Ana González-Pinto
Affiliation:
Department of Psychiatry, Santiago Apostol Hospital, Osakidetza Mental Health System, CIBERSAM, Vitoria, Spain
Flávio Kapczinski
Affiliation:
Bípolar Disorders Program, Molecular Psychiatry Laboratory, Hospital de Clinicas de Porto Alegre, Ramiro Barcelos, Porto Alegre, RS, Brazil
Eduard Vieta*
Affiliation:
Bipolar Disorders Program, Clinical Institute of Neuroscience, Hospital Clinic of Barcelona, CIBERSAM, Villarroel, Barcelona, Spain
*
Eduard Vieta, Bipolar Disorders Program, Clinical Institute of Neuroscience, University Clinic Hospital of Barcelona, Villarroel 170, 08036-Barcelona, Spain. Tel: +34932275401; Fax: +34932279876; E-mail: evieta@clinic.ub.es
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Abstract

Objective:

The aim of the present study was to assess the association between previous suicide attempts and functional impairment among euthymic patients with bipolar disorder (BD).

Methods:

Seventy-one Diagnostic Statistical Manual IV (DSM-IV) patients with BD and 61 healthy volunteers were recruited from the Bipolar Disorder Program at the Clinic Hospital of Barcelona. Patients with (n = 36, 50.7%) and without (n = 35, 49.3%) previous suicide attempts were assessed using the Structured Clinical Interview for DSM-IV-TR (SCID-P). Previous suicide attempts were carefully investigated by means of patient and caregiver interview and by a standard structured interview from the protocol of our BD Program. The Functioning Assessment Short Test (FAST) was employed to assess functional impairment.

Results:

Euthymic patients with previous suicide attempts showed functional impairment, particularly in occupational (F = 30.39; p = 0.001) and cognitive functioning (F = 18.43; p = 0.001). In addition, family history of psychiatric illness (χ2: 6.49; degrees of freedom (df) = 2;132; p = 0.010), family history of affective disorders (χ2 = 5.57; p = 0.017), psychotic symptoms (χ2 = 5.88; p = 0.014) and axis II comorbidity were associated with previous suicide attempts (χ2 = 5.16; p = 0.021).

Conclusion:

Bipolar patients with previous suicide attempts had lower overall functioning than patients who did not attempt suicide. Previous suicide attempts were particularly associated with the occupational and cognitive domains of functioning.

Keywords

bipolar disordercognitionfunctioningoccupational functioningsuicide attempts
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 20 , Issue 6 , December 2008 , pp. 300 - 306
Copyright
Copyright © 2008 Blackwell Munksgaard

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