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Influencing negative symptoms of schizophrenia with repetitive transcranial magnetic stimulation: a case study

Published online by Cambridge University Press:  24 June 2014

Radovan Prikryl ,
Simona Skotakova ,
Tomas Kasparek ,
Eva Ceskova ,
Hana Kucerova  and
Libor Ustohal
Radovan Prikryl*
Affiliation:
Department of Psychiatry, Masaryk University, Faculty of Medicine and Faculty Hospital Brno, Brno, Czech Republic
Simona Skotakova
Affiliation:
Department of Psychiatry, Masaryk University, Faculty of Medicine and Faculty Hospital Brno, Brno, Czech Republic
Tomas Kasparek
Affiliation:
Department of Psychiatry, Masaryk University, Faculty of Medicine and Faculty Hospital Brno, Brno, Czech Republic
Eva Ceskova
Affiliation:
Department of Psychiatry, Masaryk University, Faculty of Medicine and Faculty Hospital Brno, Brno, Czech Republic
Hana Kucerova
Affiliation:
Department of Psychiatry, Masaryk University, Faculty of Medicine and Faculty Hospital Brno, Brno, Czech Republic
Libor Ustohal
Affiliation:
Department of Psychiatry, Masaryk University, Faculty of Medicine and Faculty Hospital Brno, Brno, Czech Republic
*
Radovan Prikryl, MD, PhD, Department of Psychiatry, Masaryk University, Faculty of Medicine and University Hospital Brno, Jihlavska 20, 62500 Brno, Czech Republic. Tel: +420 532 232 055; Fax: +420 332 233 706; E-mail: radovan.prikryl@post.cz
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Abstract

Background:

The present trial was designed to investigate the influence of repetitive transcranial magnetic stimulation (rTMS) on negative schizophrenic symptoms using high-frequency stimulation of the left dorsolateral prefrontal cortex in a simple blind randomized design.

Methods:

The study was carried out on a 42-year-old patient with schizophrenia (paranoid subtype) with prominent negative symptoms who was first treated with sham rTMS during the first 3 weeks and then with real high frequency during the following 3 weeks. He was rated before and after the sham and after the real rTMS therapy for positive, negative and depressive symptoms.

Results:

rTMS was superior to sham treatment in reduction of negative and depressive symptoms.

Conclusion:

High-frequency rTMS applied over the left dorsolateral prefrontal cortex led to a reduction of severity of negative symptoms in a patient with chronic schizophrenia and may be beneficial as an augmentation option to antipsychotics in the treatment of negative symptoms of schizophrenia.

Keywords

negative symptomsrTMSschizophreniatreatment
Type
Case report
Information
Acta Neuropsychiatrica , Volume 19 , Issue 1 , February 2007 , pp. 53 - 55
Copyright
Copyright © 2007 Blackwell Munksgaard

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