Hostname: page-component-cd9895bd7-7cvxr Total loading time: 0 Render date: 2024-12-26T03:58:06.226Z Has data issue: false hasContentIssue false
  • English
  • Français

Influencing negative symptoms of schizophrenia with repetitive transcranial magnetic stimulation: a case study

Published online by Cambridge University Press:  24 June 2014

Radovan Prikryl ,
Simona Skotakova ,
Tomas Kasparek ,
Eva Ceskova ,
Hana Kucerova  and
Libor Ustohal
Radovan Prikryl*
Affiliation:
Department of Psychiatry, Masaryk University, Faculty of Medicine and Faculty Hospital Brno, Brno, Czech Republic
Simona Skotakova
Affiliation:
Department of Psychiatry, Masaryk University, Faculty of Medicine and Faculty Hospital Brno, Brno, Czech Republic
Tomas Kasparek
Affiliation:
Department of Psychiatry, Masaryk University, Faculty of Medicine and Faculty Hospital Brno, Brno, Czech Republic
Eva Ceskova
Affiliation:
Department of Psychiatry, Masaryk University, Faculty of Medicine and Faculty Hospital Brno, Brno, Czech Republic
Hana Kucerova
Affiliation:
Department of Psychiatry, Masaryk University, Faculty of Medicine and Faculty Hospital Brno, Brno, Czech Republic
Libor Ustohal
Affiliation:
Department of Psychiatry, Masaryk University, Faculty of Medicine and Faculty Hospital Brno, Brno, Czech Republic
*
Radovan Prikryl, MD, PhD, Department of Psychiatry, Masaryk University, Faculty of Medicine and University Hospital Brno, Jihlavska 20, 62500 Brno, Czech Republic. Tel: +420 532 232 055; Fax: +420 332 233 706; E-mail: radovan.prikryl@post.cz
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

The present trial was designed to investigate the influence of repetitive transcranial magnetic stimulation (rTMS) on negative schizophrenic symptoms using high-frequency stimulation of the left dorsolateral prefrontal cortex in a simple blind randomized design.

Methods:

The study was carried out on a 42-year-old patient with schizophrenia (paranoid subtype) with prominent negative symptoms who was first treated with sham rTMS during the first 3 weeks and then with real high frequency during the following 3 weeks. He was rated before and after the sham and after the real rTMS therapy for positive, negative and depressive symptoms.

Results:

rTMS was superior to sham treatment in reduction of negative and depressive symptoms.

Conclusion:

High-frequency rTMS applied over the left dorsolateral prefrontal cortex led to a reduction of severity of negative symptoms in a patient with chronic schizophrenia and may be beneficial as an augmentation option to antipsychotics in the treatment of negative symptoms of schizophrenia.

Keywords

negative symptomsrTMSschizophreniatreatment
Type
Case report
Information
Acta Neuropsychiatrica , Volume 19 , Issue 1 , February 2007 , pp. 53 - 55
Copyright
Copyright © 2007 Blackwell Munksgaard

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Post, RM, Kimbrell, TA, Frye, M. Implications of kindling and quenching for the possible frequency dependence of rTMS. CNS Spectrums 1997;2:54–60. CrossRefGoogle Scholar
Potkin, SG, Alva, G, Fleming, Ket al. A PET study of the pathophysiology of negative symptoms in schizophrenia. Am J Psychiatry 2002;159:227–237. CrossRefGoogle Scholar
Karreman, M, Moghaddam, B. The prefrontal cortex regulates the basal release of dopamine in the limbic striatum: an effect mediated by ventral tegmental area. J Neurochem 1996;66:589–598. CrossRefGoogle ScholarPubMed
Strafella, AP, Paus, T, Barrett, J, Dagher, A. Repetitive transcranial magnetic stimulation of the human prefrontal cortex induces dopamine release in the caudate nucleus. J Neurosci 2001;21:1–4. Google ScholarPubMed
Cohen, E, Bernardo, M, Misana, J, Arrufat, FJ, Navarro, V, Vall, S. Repetitive transcranial magnetic stimulation in the treatment of chronic negative schizophrenia: a pilot study. J Neurol Neurosurg Psychiatr 1999;67:129–130. CrossRefGoogle ScholarPubMed
Rollnik, JD, Huber, TJ, Mogk, H, Siggelkow, S, Kropp, S, Dengler, R. High frequency repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex in schizophrenic patients. Neuroreport 2000;11:4013–4015. CrossRefGoogle ScholarPubMed
Langguth, B, Eichhammer, P, Kharraz, A, Wiegand, R, Hajak, G. Repetitive transkranielle Magnetstimulation bei Schizophrenie. Nervenheilkunde 2003;22:1764–1768. Google Scholar
Klein, E, Kolsky, Y, Puyerovsky, M, Koren, D, Chistyakov, A, Feinsod, M. Right prefrontal slow repetitive transcranial magnetic stimulation in schizophrenia: a double blind sham-controlled pilot study. Biol Psychiatry 1999;46:1451–1454. CrossRefGoogle ScholarPubMed
Holi, MM, Eronen, M, Toivonen, K, Marttunen, M, Naukkainen, H. Left prefrontal repetitive transcranial magnetic stimulation in schizophrenia. Schizophr Bull 2004;30:429–434. CrossRefGoogle Scholar
Sachdev, P, Loo, C, Mitchell, P, Malhi, G. Transcranial magnetic stimulation for the deficit syndrome of schizophrenia: a pilot investigation. Psychiatry Clin Neurosci 2005;59:354–357. CrossRefGoogle ScholarPubMed
Tracy, DK, Shergill, SS. Imaging auditory hallucinations in schizophrenia. Acta Neuropsychiatrica 2006;18:71–78. CrossRefGoogle Scholar