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Lack of association between BDNF Val66Met gene polymorphism and late-onset depression in a Chinese Han population

Published online by Cambridge University Press:  24 June 2014

Jiayong You ,
Yonggui Yuan ,
Yanyan Shi ,
Zhijun Zhang ,
Xiangrong Zhang  and
Hailin Li
Jiayong You
Affiliation:
Department of Psychiatry, Nanjing Brain Hospital affiliated to Nanjing Medical University, Nanjing, 210029, China
Yonggui Yuan*
Affiliation:
Department of Psychiatry, Nanjing Brain Hospital affiliated to Nanjing Medical University, Nanjing, 210029, China School of Clinical Medicine, Southeast University, Nanjing, 210009, China
Yanyan Shi
Affiliation:
Department of Psychiatry, Nanjing Brain Hospital affiliated to Nanjing Medical University, Nanjing, 210029, China
Zhijun Zhang*
Affiliation:
Department of Neuropsychiatry, Affiliated ZhongDa Hospital of Southeast University, Nanjing, 210009, China
Xiangrong Zhang
Affiliation:
Department of Psychiatry, Nanjing Brain Hospital affiliated to Nanjing Medical University, Nanjing, 210029, China
Hailin Li
Affiliation:
Department of Psychiatry, Nanjing Brain Hospital affiliated to Nanjing Medical University, Nanjing, 210029, China
*
Yonggui Yuan, Department of Psychiatry, Nanjing Brain Hospital affiliated to Nanjing Medical University, Guangzhou Road 264#, Nanjing 210029, PR China. Tel: +86 25 83700011-6209; Fax: +86 25 8370 9025; E-mail: yygylh2000@sina.com.cn
Zhijun Zhang, Department of Neurology, Affiliated ZhongDa Hospital of Southeast University. DingJiaQiao Road 87#, Nanjing 210009, PR China. E-mail: zhijunzhang838@yahoo.com.cn
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Abstract

Background:

Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene has been suggested to be associated with major depressive disorder (MDD). There were a few reports of the relationship between the variant and late-onset depression (LOD) in Chinese Han population.

Objective:

To investigate the relationship among BDNF Val66Met gene variants, BDNF plasma level and LOD.

Methods:

Chinese Han patients with LOD (n = 99) and control subjects (n = 110) were assessed for BDNF Val66Met gene polymorphism. BDNF plasma level was tested only in LOD.

Results:

There were no significant differences in genotypes and allele frequencies between cases and controls (p = 0.744 and p = 0.845, respectively). Plasma BDNF level also did not show significant differences in three genotypes in LOD (p = 0.860).

Conclusion:

The Val66Met polymorphism in BDNF gene may not confer susceptibility to LOD in Chinese Han population.

Keywords

brain-derived neurotrophic factor (BDNF)genelate-onset depression
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 21 , Issue 4 , August 2009 , pp. 186 - 190
Copyright
Copyright © 2009 John Wiley & Sons A/S

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