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Polyunsaturated fatty acids in depression

Published online by Cambridge University Press:  24 June 2014

Dirk van West  and
Michael Maes
Dirk van West
Affiliation:
Clinical Research Center for Mental Health (CRC-MH), Antwerp, Belgium
Michael Maes*
Affiliation:
Clinical Research Center for Mental Health (CRC-MH), Antwerp, Belgium Department of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, the Netherlands IRCCS, Fatebenefratelli, Brescia, Italy Department of Psychiatry, Vanderbilt University, TN, USA
*
Professor Dr M. Maes MD, PhD, Department of Psychiatry, University Hospital of Maastricht, Postbus 5800, 6202 AZ Maastricht, the Netherlands. Tel: (++) 31 43 3877443; Fax: (++) 31 43 3875444; E-mail: crc.mh@skynet.be http://www.marquiswhoswho.net/MMAES/http://www.ediver.be
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Abstract

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Type
Review Article
Information
Acta Neuropsychiatrica , Volume 15 , Issue 1 , February 2003 , pp. 15 - 21
Copyright
Copyright © 2003 Blackwell Munksgaard

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References

Hibbeln, JR. Fish consumption and major depression [letter]. Lancet 1998;321: 1213. CrossRefGoogle Scholar
Nettleton, JA.Omega 3 fatty acids: comparison of plant and seafood sources in human nutrition. J Am Dietet Assoc 1991;91: 331–337. Google ScholarPubMed
Durrington, PN.Lipids and their metabolism. In: Horrobin, PN, ed. Hyperlipidaemia, diagnosis and management. Cambridge: Butterworth-Heinemann, 1995: 4–24. Google Scholar
Linscheer, WG, Vergroesen, AJ., Shils, ME, Young, VR, eds. Modern nutrition in health and disease. Philadelpia: Lea & Febiger, 1988: 72–107. Google Scholar
Horrobin, DF.Essential fatty acids, psychiatric disorders and neuropathies. In: Horrobin, DF, ed. Omega-6 essential fatty acids: pathophysiology and roles in clinical medicine. New York: Wiley-Liss, 1990: 305–320. Google Scholar
Smith, RS.The macrophage theory of depression. Med Hypoth 1991;35: 298–306. CrossRefGoogle Scholar
Maes, M, Delanghe, J, Meltzer, HY, D'Hondt, P, Cosyns, P.Lower degree of esterification of serum cholesterol in depression: relevance for depression and suicide research. Acta Psychiatr Scand 1994;90: 252–258.CrossRefGoogle ScholarPubMed
Maes, M, Smith, R, Christophe, A, Cosyns, A, Desnyder, R, Meltzer, HY. Fatty acid composition in major depression: decreased ω3 fractions in cholesteryl esters and increased c20 : 4ω6/c20 : 5ω3 ratio in cholesteryl esters and phospholipids. J Affect Disord 1996;38: 35–46.CrossRefGoogle Scholar
Maes, M, Smith, R, Christophe, Aet al. Lower serum high density lipoprotein cholesterol (HDL-C) in major depression and in depressed men with serious suicidal attempts: relationships to immune-inflammatory markers. Acta Psychiatr Scand 1997;95: 212–221.CrossRefGoogle Scholar
Hibbeln, JR, Salem, N.Dietary polyunsaturated fatty acids and depression: when cholesterol does not satisfy. Am J Clin Nutr 1995;62: 1–9.Google Scholar
Maes, M, Smith, R. Fatty acids, cytokines and major depression [Editorial]. Biol Psychiatry 1998;43:319–320. Google Scholar
Peet, M, Murphy, B, Shay, J, Horrobin, D.Depletion of omega-3 fatty acid levels in red blood cell membranes of depressive patients. Biol Psychiatry 1998;43: 315–319.CrossRefGoogle ScholarPubMed
Morgan, RE, Palinkas, LA, Barrett-Connor, EL, Wingard, DL.Plasma cholesterol and depressive symptoms in older men. Lancet 1993;341: 75–79.CrossRefGoogle ScholarPubMed
Glueck, CJ, Tieger, M, Kunkel, R, Hamer, T, Tracy, T, Speirs, J.Hypocholesterolemia and affective disorders. Am J Med Sci 1994;308: 218–225.CrossRefGoogle ScholarPubMed
Swartz, C.Albumin decrement in depression and cholesterol decrement in mania. J Affect Disord 1990;19: 173–176.CrossRefGoogle ScholarPubMed
Weidner, G, Connor, SL, Hollis, JF, Connor, WE.Improvements in hostility and depression in relation to dietary change and cholesterol lowering. The Family Heart Study. Ann Int Med 1992;117: 820–823. CrossRefGoogle ScholarPubMed
McCallum, J, Simons, L, Simons, J, Friedlander, Y.Low serum cholesterol is not associated with depression in the elderly: data from an Australian community study. Aust NZ J Med 1994;24: 561–564. CrossRefGoogle Scholar
Muldoon, MF, Manuck, SB, Mathews, KM.Lowering cholesterol concentrations and mortality: a quantitative review of primary prevention trials. Br Med J 1990;301: 309–314. CrossRefGoogle ScholarPubMed
Engelberg, H.Low serum cholesterol and suicide. Lancet 1992;339: 727–729.CrossRefGoogle ScholarPubMed
Lindberg, G, Rastam, L, Gullberg, B, Eklund, GA.Low serum cholesterol concentration and short term mortality from injuries in men and women. Br Med J 1992;305: 277–279. CrossRefGoogle ScholarPubMed
Golier, JA, Marzuk, PM, Leon, AC, Weiner, C, Tardiff, K.Low serum cholesterol level and attempted suicide. Am J Psychiatry 1995;152: 419–423.Google ScholarPubMed
Sullivan, PF, Joyce, PR, Bulik, CM, Mulder, RT, Oukley-Browne, M.Total cholesterol and suicidality in depression. Biol Psychiatry 1994;36: 472–477.CrossRefGoogle ScholarPubMed
Edwards, R, Peet, M, Shay, J, Horrobin, D.Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients. J Affect Disord 1998;48: 149–155.CrossRefGoogle ScholarPubMed
Maes, M, Christophe, A, Delanghe, J, Altamura, C, Neels, H, Meltzer, HY.Lowered omega 3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients. Psychiatr Res 1999;85: 275–291. CrossRefGoogle ScholarPubMed
Adams, PB, Lawson, S, Sanigorski, A, Sinclair, AJ.Arachidonic acid to eicosapentaenoic acid ratio in blood correlates positively with clinical symptoms of depression. Lipids 1996;31 (Suppl.):S157–S161.CrossRefGoogle ScholarPubMed
Subbaiah, PV, Banerji, B, Gregg, RE, Bagdade, JD.Molecular species of cholesteryl esters formed in abetalipoproteinemia: effect of apoprotein B-containing lipoproteins. J Lipid Res 1990;21: 927–932. Google Scholar
Norum, K, Gjone, E, Glomset, J.Familial lecithin: cholesterol acyltransferase defiency, including fish eye disease. In: Scriver, C, Beaudet, A, Sly, W, Valle, D, eds. The metabolic bias of inherited disease. New York: McGraw Hill Inc., 1989: 1181–1194. Google Scholar
Sabine, JR.Cholesterol. New York/Basel: Marcel Dekker, 1977. Google ScholarPubMed
Bernstam, VA.Genetic aspects in reverse cholesterol transport. In: Handbook of gene level diagnostics in clinical practice. Ann Arbor: CRC Press, 1992: 178–181. Google Scholar
Maes, M.Evidence for an immune response in major depression: a review and hypothesis. Progr Psychopharmacol Biol Psychiatry 1995;19: 11–38. CrossRefGoogle ScholarPubMed
Maes, M, Smith, R, Scharpé, S.The monocyte-T lymphocyte hypothesis of major depression [Editorial]. Psychoneuroendocrinology 1995;20:111–116. CrossRefGoogle Scholar
Song, C, Dinan, T, Leonard, BE.Changes in immunoglobulin, complement and acute phase protein levels in the depressed patients and normal controls. J Affect Disord 1994;30: 283–288.CrossRefGoogle ScholarPubMed
Cunnane, SC, Yang, J, Chen, ZY.Low zinc intake increases apparent oxidation of linoleic and alpha-linolenic acids in the pregnant rat. Can J Physiol Pharmacol 1993;71: 205–210.CrossRefGoogle ScholarPubMed
Russo, C, Olivieri, O, Girelli, Det al. Increased membrane ratios of metabolite to precursor fatty acid in essential hypertension. Hypertension 1997;29: 1058–1063.CrossRefGoogle ScholarPubMed
Grunfeld, C, Feingold, KR.Tumor necrosis factor, interleukin, and interferon induced changes in lipid metabolism as part of host defense. Proc Soc Exp Biol Med 1992;200: 224–227.CrossRefGoogle ScholarPubMed
Memon, RA, Feingold, KR, Grunfeld, C.Role of cytokines in lipid metabolism and cachexia. In: Aggarwal, BB, Puri, RK, eds. Human cytokines: their role in disease and therapy. Cambridge: Blackwell Science, 1995: 239–251. Google Scholar
Ettinger, WH, Miller, LD, Albers, JJ, Smith, TK, Parks, JS.Lipopolysaccharide and tumor necrosis factor cause a fall in plasma concentration of lecithin: acyltransferase in cynomolgus monkeys. J Lipid Res 1990;31: 1099–1107.Google Scholar
Maes, M, De Vos, N, Pioli, Ret al. Lower serum vitamin E concentrations in major depression: another marker of lowered antioxidant defences in that illness. J Affect Disord 2000;58: 241–246.CrossRefGoogle Scholar
Farrell, PM.Vitamin E. In: Shils, ME, Young, VR, eds. Modern nutrition in health and disease. Philadelphia: Lea & Febiger, 1988: 340–354. Google Scholar
Gutteridge, JMC, Halliwell, B.Antioxidants in nutrition, health and disease. Oxford: University Press Oxford, 1994. Google Scholar
Maes, M, Weeckx, S, Wauters, Aet al. Biological variability in serum vitamin E concentrations: relation to serum lipids. Clin Chem 1996;42: 1824–1831.Google ScholarPubMed
Cham, BE, Smith, JL, Colquhoun, DM.Correlations between cholesterol, vitamin E and vitamin K1 in serum: paradoxical relationships to established epidemiological risk factors for cardiovascular disease. Clin Chem 1998;44: 1753–1755.Google ScholarPubMed
Packer, L, Fuchs, JL.Vitamin E in health and disease. New York: Marcel Dekker, 1993. Google ScholarPubMed
Louw, JA, Werbeck, A, Louw, ME, Kotze, TJ, Cooper, R, Labadarios, D.Blood vitamin concentrations during the acute-phase response. Crit Care Med 1992;20: 934–941.CrossRefGoogle ScholarPubMed
Devaraj, S, Li, D, Jialal, I.The effects of alpha tocopherol supplementation on monocyte function. Decreased lipid oxidation, interleukin 1 beta secretion, and monocyte adhesion to endothelium. J Clin Invest 1996;98: 756–763.CrossRefGoogle ScholarPubMed
Tudhope, GR, Hopkins, J.Lipid peroxidation in human erythrocytes in tocopherol deficiency. Acta Haematol 1975;53: 98–104.CrossRefGoogle ScholarPubMed
Meydani, SN, Endres, S, Woods, MM.Oral (ω3) fatty acid supplementation suppresses cytokine production and lymphocyte proliferation: comparison between young and older women. J Nutr 1991;121: 547–555.Google Scholar
Soyland, E, Lea, T, Sandstad, B, Drevon, A.Dietary supplementation with very long chain ω3 fatty acids in man decreases expression of the interleukin-2-receptor (CD25) on mitogen-stimulated lymphocytes from patients with inflammatory skin diseases. Eur J Clin Inv 1994;24: 236–242. CrossRefGoogle Scholar
Hayashi, N, Tashiro, T, Yamamori, Het al. Effects of intravenous omega-3 and omega-6 fat emulsion on cytokine production and delayed type hypersensitivity in burned rats receiving total parental nutrition. JPEN 1998;22: 363–367. CrossRefGoogle Scholar
Tashiro, T, Yamamori, H, Takagi, K, Hayashi, N, Furukawa, K, Nakajima, N.ω3 versus ω6 polyunsaturated fatty acids in critical illness. Nutrition 1998;14: 551–553.CrossRefGoogle Scholar
Calder, PC.Immunoregulatory and anti-inflammatory effects of ω3 polyunsaturated fatty acids. Braz J Med Biol Res 1998;31: 467–490.CrossRefGoogle Scholar
Espersen, GT, Grunnet, N, Lervang, HHet al. Decreased interleukin-1 beta levels in plasma from rheumatoid arthritis patients after dietary supplementation with n-3-polyunsaturated fatty acids. Clin Rheumatol 1992;11: 393–395.CrossRefGoogle ScholarPubMed
Endres, S.Messengers and mediators: interactions among lipids, eicosanoids and cytokines. Am J Clin Nutr 1993;57: 798–800. Google ScholarPubMed
Purasiri, P, Murray, A, Richardson, S, Heys, SD, Horrobin, D, Eremin, O.Modulation of cytokine production in vivo by dietary essential fatty acids in patients with colorectal cancer. Clin Sci 1994;87: 711–717.CrossRefGoogle ScholarPubMed
Gallai, V, Sarchielli, P, Trequattrini, Aet al. Cytokine secretion and eicosanoid production in the peripheral blood mononuclear cells of MS patients undergoing dietary supplementation with ω3 polyunsaturated fatty acids. J Neuroimmunol 1995;56: 143–153.CrossRefGoogle Scholar
Caughey, GE, Mantzioris, E, Gibson, RA, Cleland, LG, James, ML.The effect on human tumor necrosis factor α and interleukin 1β production of diets enriched in ω3 fatty acids from vegetable oil or fish oil. J Am Clin Nutr 1996;63: 116–122. Google ScholarPubMed
Nanji, AA, Zakim, D, Rahemtulla, Aet al. Dietary saturated fatty acids down-regulate cyclooxygenase-2 and tumor necrosis factor alpha and reverse fibrosis in alcohol-induced liver disease in the rat. Hepatology 1997;26: 1538–1545.CrossRefGoogle ScholarPubMed
Endres, S, Ghorbani, R, Kelley, VEet al. The effect of dietary supplementation with n-3-polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 1989;320: 265–271.CrossRefGoogle ScholarPubMed
Kremer, JM, Lawrence, DA, Jubiz, Wet al. Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis. Arthritis Rheum 1990;33: 810–820.CrossRefGoogle ScholarPubMed
Meydani, SN, Lichtenstein, AH, Cornwall, Set al. Immunologic effects of National Cholesterol Education Panel Step-2 diets with and without fish-derived n-3 fatty acid enrichment. J Clin Invest 1993;92: 105–113.CrossRefGoogle ScholarPubMed
Maes, M, Christophe, A, Bosmans, E, Lin, A, Neels, H.In humans, serum polyunsaturated fatty acid levels predict the response of proinflammatory cytokines to psychological stress. Biol Psychiatry 2000;47: 910–920.CrossRefGoogle Scholar
Murphy, MG.Dietary fatty acids and membrane protein function. J Nutr Biochem 1990;1: 68–79. CrossRefGoogle ScholarPubMed
Bourre, JM, Dumont, O, Durant, G.Brain phospholipids as dietary source of ω3 polyunsaturated fatty acids for nervous tissue in the rat. J Neurochem 1993;60: 2018–2028.CrossRefGoogle Scholar
Jonas, A.Lecithin cholesterol acyltransferase. In: Gotto, GR, ed. Plasma lipoproteins. Amsterdam: Elsevier Science Publishers, 1987: 299–333. CrossRefGoogle Scholar
Yeagle, PL.Cholesterol and the cell membrane. In: Yeagle, PL, ed. Plasma lipoproteins. Amsterdam: Elsevier Science Publishers, 1987: 299–333. Google Scholar
Gjone, E.Familial lecithin: cholesterol acyltransferase (LCAT) deficiency. An updated review. Ophthal Paediatr Genet 1988;9: 167–169. CrossRefGoogle ScholarPubMed
McIntyre, N.Familial LCAT deficiency and fish-eye disease. J Inherit Metab Dis 1988;11: 45–56. CrossRefGoogle ScholarPubMed
Heron, DS, Shinitzky, M, Hershkowitz, M, Samuel, D.Lipid fluidity markedly modulates the binding of serotonin to mouse brain membranes. Proc Natl Acad Sci USA 1980;77: 7463–7467.CrossRefGoogle ScholarPubMed
Miyamoto, A, Araiso, T, Koyama, T, Ohshika, H.Membrane viscosity correlates with alpha 1-adrenergic signal transduction of the aged rat cerebral cortex. J Neurochem 1990;55: 70–75.CrossRefGoogle ScholarPubMed
Tsutsumi, S, Tsuji, K, Ogawa, K, Ito, T, Satake, T.Effect of dietary salt and cholesterol loading on vascular adrenergic receptors. Blood Vessels 1988;25: 209–216.Google ScholarPubMed
Maguire, PA, Druse, MJ.The influence of cholesterol on synaptic fluidity, dopamine D1 binding and dopamine-stimulated adenylate cyclase. Brain Res Bull 1989;23: 69–74.CrossRefGoogle ScholarPubMed
Jain, ML, Curtis, B, Forbes, J, Krantz, J Jr.The effect of fat diet on reserpine-induced depression in mice. Res Commun Chem Pathol Pharmacol 1973;6: 1091–1093.Google ScholarPubMed
Toffano, G, Leon, A, Benvegnu, D, Boarato, E, Azzone, GF.Effect of brain cortex phospholipids on the catecholamine content of mouse brain. Pharmacol Res Commun 1976;6: 1091–1093. Google Scholar
Mandel, AJ.Non-equilibrium behavior of some brain enzyme and receptor systems. Ann Rev Pharmacol Toxicol 1984;24: 237–274. CrossRefGoogle Scholar
Block, E, Edwards, D.Effects of plasma membrane fluidity on serotonin transport by endothelial cells. Am J Physiol 1987;253: 672–678. Google ScholarPubMed
Crane, SB, Greenwood, CE.Dietary fat source influences neuronal mitochondrial monoamine oxidase activity and macronutrient selection in rats. Pharmacol Biochem Behav 1987;27: 1–6.CrossRefGoogle ScholarPubMed
Mullen, BJ, Martin, RJ.The effect of dietary fat on diet selection may involve central serotonin. Am J Physiol 1992;263: 559–563. Google ScholarPubMed
Delion, S, Chalon, S, Guilloteau, D, Besnard, JC, Durand, G.Alpha-linolenic acid dietary deficiency alters age-related changes of dopaminergic and serotoninergic neurotransmission in the rat frontal cortex. J Neurochem 1996;66: 1582–1591.CrossRefGoogle ScholarPubMed
Maes, M, Meltzer, HY.The serotonin hypothesis of major depression. In: Bloom, FE, Kupher, DJ, eds. Psychopharmacology, the fourth generation of progress. New York: Raven Press, Year?: 933–941. Google Scholar
Gerritsen, ME, Schwarz, SM, Medow, MS.Glucocorticoid-mediated alterations in fluidity of rabbit cardiac muscle microvessel endothelial cell membranes: influences on eicosanoid release. Biochim Biophys Acta 1991;1065: 63–68.CrossRefGoogle ScholarPubMed
Wick, G, Huber, LA, Offner, Fet al. Immunodeficiency in old age. Curr Prob Dermatol 1989;18: 120–130. CrossRefGoogle ScholarPubMed
Huber, LA, Xu, QB, Jurgens, Get al. Correlation of lymphocyte lipid composition membrane microviscosity and mitogen response in the aged. Eur J Immunol 1991;21: 2761–2765.CrossRefGoogle ScholarPubMed
Maes, M, Vandewoude, M, Scharpé, S, Declerck, L, Stevens, W, Lepoutre, L.Anthropometric and biochemical assessment of the nutritional state in depression: evidence for lower visceral protein plasma levels in depression. J Affect Disord 1991;23: 25–33.CrossRefGoogle ScholarPubMed
Christophe, A, Vermeulen, A.Effects of weight loss on the fatty acid composition of serum lipids in obese women. Ann Nutr Metab 1992;36: 336–342.CrossRefGoogle ScholarPubMed
Klerman, GL, Weisman, MM.Increasing rates of depression. JAMA 1989;261: 2229–2235.CrossRefGoogle Scholar
Leaf, A, Weber, PC.A new era for science in nutrition. Am J Clin Nutr 1987;45: 1048–1053.Google ScholarPubMed
Sinclair, AJ, Johnson, L, O'Dea, K, Holman, RT.Diets rich in lean beef increase arachidonic acid and long-chain ω3 polyunsaturated fatty acid levels in plasma phospholipids. Lipids 1994;29: 337–343.CrossRefGoogle Scholar
Kannel, WB, Wolf, PA, Castelli, WP, D'Agostino, RB.Fibrinogen and risk of cardiovascular disease. The Framingham study. JAMA 1987;258: 1183–1186.CrossRefGoogle ScholarPubMed
Booth-Kewley, S, Friedman, HS.Psychological predictors of heart disease: a quantitative review. Psychol Bull 1987;101: 343–362.CrossRefGoogle ScholarPubMed
Heiss, G, Johnson, NJ, Reiland, S, Davis, CE, Tyroler, JA.The epidemiology of plasma high-density lipoprotein cholesterol levels. The Lipid Res Clinics Program Prevalence Study summary. Circulation 1980;62: 116–136.Google Scholar
Connor, WE, Cerqueria, MT, Connor, RW, Wallace, RB, Malinow, MR, Casdorph, HR.The plasma lipids, lipoproteins, and diet of the Tarahumara Indians of Mexico. Am J Clin Nutr 1987;31: 1131–1142. Google Scholar
Belgian Lipid Club. Diagnose en Behandeling van Hyperlipidemieen bij Volwassenen. Gids in Zakformaat. De Huisarts 1994;Suppl.: 246. Google Scholar
Kromhout, B, Bosschieter, EB, Coulander, CL.The inverse relationship between fish consumption and 20-year mortality from coronary heart disease. N Engl J Med 1985;312: 1205–1209.CrossRefGoogle Scholar