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Relation between neuritic plaques and depressive state in Alzheimer's disease

Published online by Cambridge University Press:  24 June 2014

Gerben Meynen ,
Heleen Van Stralen ,
Jan H. Smit ,
Wouter Kamphorst ,
Dick F. Swaab  and
Witte J.G. Hoogendijk
Gerben Meynen
Affiliation:
Netherlands Institute for Neuroscience, an Institute of the KNAW, Amsterdam, The Netherlands Department of Psychiatry, NCA, CNCR, VU University Medical Centre, Amsterdam, The Netherlands
Heleen Van Stralen
Affiliation:
Department of Psychiatry, NCA, CNCR, VU University Medical Centre, Amsterdam, The Netherlands
Jan H. Smit
Affiliation:
Department of Psychiatry, NCA, CNCR, VU University Medical Centre, Amsterdam, The Netherlands
Wouter Kamphorst
Affiliation:
Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
Dick F. Swaab
Affiliation:
Netherlands Institute for Neuroscience, an Institute of the KNAW, Amsterdam, The Netherlands
Witte J.G. Hoogendijk*
Affiliation:
Department of Psychiatry, NCA, CNCR, VU University Medical Centre, Amsterdam, The Netherlands
*
Witte J.G. Hoogendijk, Department of Psychiatry, VU University Medical Centre, A.J. Ernststraat 887, 1081 HL Amsterdam, The Netherlands. Tel: +31654395575; Fax: +3120-6737458; E-mail: w.hoogendijk@ggzingeest.nl
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Abstract

Meynen G, Van Stralen H, Smit JH, Kamphorst W, Swaab DF, Hoogendijk WJG. Relation between neuritic plaques and depressive state in Alzheimer's disease.

Background:

To investigate for the first time in a prospective study the relationship between depressive state and the neuropathological hallmarks of Alzheimer's disease, using a scale for depressive symptoms in dementia, while controlling for clinical severity of dementia.

Method:

Within the framework of a prospective longitudinal study of depression in Alzheimer's disease, patients with dementia underwent a clinical evaluation every six months during the last years of their lives, using the Cornell scale for depression in dementia to assess depressive symptoms and using the Functional Assessment Staging scale to control for clinical severity of dementia. The brains of 43 Alzheimer patients were obtained. The last clinical evaluations prior to death together with post-mortem neuropathology measures were analysed.

Results:

We found a correlation between the Cornell scores and the sum score for the density of neuritic plaques in the entire cortex (p = 0.027), and even stronger in the temporal cortex (p = 0.012). The observed correlations were independent of sex, age of death, clinical dementia severity and duration of Alzheimer's disease.

Conclusions:

This study shows a positive relationship between depressive state at time of death and the presence of neuritic plaques in Alzheimer's disease, which is independent of the clinical severity of dementia.

Keywords

Alzheimer's diseasedepressive disordermood disorderneuritic plaquesneuropathologypost-mortem
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 22 , Issue 1 , February 2010 , pp. 14 - 20
Copyright
Copyright © 2009 John Wiley & Sons A/S

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