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Association between the NOTCH4 gene rs3131296 polymorphism with schizophrenia risk in the Chinese Zhuang population and Chinese Han population

Published online by Cambridge University Press:  27 February 2014

Li Su Open the ORCID record for Li Su [Opens in a new window] ,
Jianxiong Long ,
Baoyun Liang ,
Lian Gu ,
Runde Pan ,
Liushan Li ,
Yang Zhou ,
Xianyan Tang ,
Junjun Jiang  and
Qiang Chen
...Show all authors
Li Su
Affiliation:
Epidemiology and Health Statistics Department, School of Public Health of Guangxi Medical University, Nanning, Guangxi, PR China
Jianxiong Long
Affiliation:
Epidemiology and Health Statistics Department, School of Public Health of Guangxi Medical University, Nanning, Guangxi, PR China
Baoyun Liang
Affiliation:
Department of Internal Neurology, First Affiliated Hospital to Guangxi University of Chinese Medicine, Nanning, Guangxi, PR China
Lian Gu
Affiliation:
Department of Internal Neurology, First Affiliated Hospital to Guangxi University of Chinese Medicine, Nanning, Guangxi, PR China
Runde Pan
Affiliation:
Guangxi Brain Hospital, Liuzhou, Guangxi, PR China
Liushan Li
Affiliation:
Epidemiology and Health Statistics Department, School of Public Health of Guangxi Medical University, Nanning, Guangxi, PR China
Yang Zhou
Affiliation:
Epidemiology and Health Statistics Department, School of Public Health of Guangxi Medical University, Nanning, Guangxi, PR China
Xianyan Tang
Affiliation:
Epidemiology and Health Statistics Department, School of Public Health of Guangxi Medical University, Nanning, Guangxi, PR China
Junjun Jiang
Affiliation:
Epidemiology and Health Statistics Department, School of Public Health of Guangxi Medical University, Nanning, Guangxi, PR China
Qiang Chen*
Affiliation:
Guangxi Brain Hospital, Liuzhou, Guangxi, PR China
Bo Wei*
Affiliation:
Epidemiology and Health Statistics Department, School of Public Health of Guangxi Medical University, Nanning, Guangxi, PR China
*
Qiang Chen, Guangxi Brain Hospital, Liuzhou, Guangxi, PR China. Tel: 13907723846; Fax: +867723136028; Email: chenqiang159@yahoo.cn
Bo Wei, School of Public Health of Guangxi Medical University, Guangxi, PR China. Tel: 13978668658; Fax: +867715350823; E-mail: weibogx@163.com
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Abstract

Background

Schizophrenia (SZ) is a common severe psychiatric disorder and a complex polygenic inherited disease that has not yet been fully interpreted. Heredity was proven to play an important role in the development of SZ. The association between the NOTCH4 gene rs3131296 polymorphism and SZ was reported to reach significance at the genome-wide level; therefore, it is necessary to replicate this association in other different populations.

Methods

To evaluate the association of the NOTCH4 gene rs3131296 polymorphism with the risk for SZ, and to explore whether a significant association could be replicated in different ethnic groups of China, we conducted this case–control study on 282 SZ cases (188 Han and 94 Zhuang) and 282 controls (188 Han and 94 Zhuang) among the Chinese Zhuang and Han populations.

Results

The results showed no statistically significant difference in the genotype or allele frequencies of the NOTCH4 gene variant rs3131296 between SZ patients and healthy controls in either the Zhuang or Han samples (p > 0.05). In addition, no significant difference was found in genotype or allele frequencies of the NOTCH4 gene variant rs3131296 between cases and controls in the combined samples including Zhuang and Han samples.

Conclusions

Our study failed to replicate the significant association between the NOTCH4 gene rs3131296 polymorphism and the risk for SZ.

Keywords

association studyNOTCH4polymorphismrs3131296schizophrenia
Type
Original Articles
Information
Acta Neuropsychiatrica , Volume 26 , Issue 4 , August 2014 , pp. 240 - 245
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 2014 

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Footnotes

Li Su, Jianxiong Long, Baoyun Liang, and Lian Gu co-first authors for this article.

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