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Autism and autistic-like disorders: the hypothalamic-pituita-ry-adrenal system as a model for research

Published online by Cambridge University Press:  18 September 2015

L.M.C. Jansen ,
C.C. Gispen-De Wied  and
H. Van Engeland
L.M.C. Jansen
Affiliation:
Onderzoeksschool Rudolf Magnus Instituut, Afdeling Kinder- en Jeugdpsychiatrie, Universiteit van Utrecht, Academisch Ziekenhuis
C.C. Gispen-De Wied*
Affiliation:
Onderzoeksschool Rudolf Magnus Instituut, Afdeling Kinder- en Jeugdpsychiatrie, Universiteit van Utrecht, Academisch Ziekenhuis
H. Van Engeland
Affiliation:
Onderzoeksschool Rudolf Magnus Instituut, Afdeling Kinder- en Jeugdpsychiatrie, Universiteit van Utrecht, Academisch Ziekenhuis
*
Academisch Ziekenhuis Utrecht, Hp A01.126, Postbus 85500, 3508 GA Utrecht
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Summary

In this article an overview is given of the differential diagnosis of autism and autistic-like disorders. The diagnosis of the so-called ‘Multiple Complex Developmental Disorders’ (MCDD) as a distinct entity is discussed in relation to autism and schizophrenia.

Biological research and the relevance of results until recently are discussed. Finally, the importance of the hypothalamic-pituitary-adrenal system (HPA system) as a model for research is proposed. Research on the flexibility of this system may contribute in understanding the ways of stress processing in disorders like autism, MCDD and schizophrenia.

Keywords

AutismMCDDhypothalamic-pituitary-adrenal systemCortisolstressAutismMCDDhypothalamic-pituitary-adrenal systemCortisolstress
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 7 , Issue 4 , December 1995 , pp. 106 - 113
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1995

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