Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-11T03:00:58.519Z Has data issue: false hasContentIssue false
  • English
  • Français

Biological and psychopharmacological aspects of impulse-control disorders

Published online by Cambridge University Press:  18 September 2015

W.M.A. Verhoeven  and
S. Tuinier
Get access Rights & Permissions [Opens in a new window]

Extract

Over the past decades extensive research has been performed on the presumed relationship between neurotransmitter functionality in the central nervous system and psychopathological states. Originally, in the mid-sixties it was hypothesized that depressive states may be associated with disorders in brain noradrenalin and/or serotonin (5-hydroxytryptamine; 5-HT) metabolism or function resulting in the socalled monoamine hypothesis of depression. Subsequent investigations revealed that altered 5-HT metabolism is not related to mood disorder per se, but to components of the depressive syndrome and more specifically to increased anxiety and/or signs of dysregulated aggression, including violent suicidal attempts.

Concerning aggression and other types of disruptive or impulsive behavior, research on their neurobiological determinants has been focussed mainly on indicators of central 5-HT function.

Keywords

Aggressionbuspironeserotonin
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 9 , Issue 2 , June 1997 , pp. 89 - 93
Copyright
Copyright © Cambridge University Press 1997

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Literature

1.Van Praag, HM, Asnis, G, Kahn, R, Brown, SL, Korn, M, Friendman, JM, Wetzler, S. Monoamines and abnormal behavior: a multiaminergic perspective. Br J Psychiat 1990;157:723–34.CrossRefGoogle Scholar
2.Van Praag, HM. Serotonin-related, anxiety/aggression-driven, stressor-precipitated depression. A psycho-biological hypothesis. Eur Psychiat 1996;11:57–67.CrossRefGoogle ScholarPubMed
3.Åsberg, M. Monoamine neurotransmitters in human aggressiveness and violence: a selective review. Crim Behav ment Health, 1994;4:303–27.CrossRefGoogle Scholar
4.Tuinier, S, Verhoeven, WMA, Van Praag, HM. Cerebrospinal fluid 5-hydroxyindolacetic acid and aggression, a critical reappraisal of the clinical data. Int clin Psychopharmacol 1995;10:147–56.CrossRefGoogle ScholarPubMed
5.Tuinier, S, Verhoeven, WMA, Van Praag, HM. Serotonin and disruptive behavior; A critical evaluation of the clinical data. Hum Psychopharmacol 1996;11: 469–82.3.0.CO;2-X>CrossRefGoogle Scholar
6.Tollefson, GD. Serotonin and alcohol: interrelationships. Psycho-pathology 1989; 22(suppl. l):37–48.CrossRefGoogle ScholarPubMed
7.Virkkunen, M, Eggert, M, Rawlings, R, et al.A prospective follow-up study of alcoholic violent offenders and fire setters. Arch gen Psychiat 1996;53:523–9.CrossRefGoogle ScholarPubMed
8.Møller, SE, Mortensen, EL, Breum, L, et al.Aggression and personality: association with amino acids and monoamine metabolites. Psychol Med 1996;26:323–31.CrossRefGoogle ScholarPubMed
9.Verhoeven, WMA, Tuinier, S, Sijben, NES. Biological aspects and pharmacological treatment of self-injurious behavior in persons with mental retardation. In: Fletcher, RJ, Dosen, A, eds. Mental Health Aspects of mental Retardation. Progress in Assessment and Treatment. Lexington Books. New York: Free Press McMillan Ine, 1993:291–323.Google Scholar
10.Tuinier, S, Verhoeven, WMA. Dimensional classification and behavioral pharmacology of personality disorders; a review and hypothesis. Eur Neuropsychopharmacol 1995;5:135–46.CrossRefGoogle ScholarPubMed
11.Markovitz, P. Pharmacotherapy of impulsivity, aggression, and related disorders. In: Hollander, E, Stein, DJ, eds. Impulsivity and aggression. Chichester: Wiley, 1995:263–87.Google Scholar
12.Mak, M, De Koning, P, Mos, J, Olivier, C. Preclinical and clinical studies on the role of 5-HT, receptors in aggression. In: Hollander, E, Stein, DJ, eds. Impulsivity and aggression. Chichester: Wiley, 1995:289–311.Google Scholar
13.Mos, J, Van Aken, HHM, Van Oorschot, R, et al.Chronic treatment with eltoprazine does not lead to tolerance in its anti-aggressive action, in contrast to haloperidol. Eur Neuropsychopharmacol 1996;6:1–7.CrossRefGoogle Scholar
14.Cloninger, CR. The psychobiological regulation of social cooperation. Nature Med 1995;1:623–5.CrossRefGoogle ScholarPubMed
15.De Kloet, RE, Joëls, M, Oitzl, M, et al.Implication of brain corticosteroid receptor diversity for the adaptation syndrome concept. In: Jasmin, G and Cantin, M, Eds. Neuroendocrinology of Stress. Methods and Achievements in Experimental Pathology 14, Basel: Karger, 1991:104–32.Google Scholar