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Cholecystokinin and panic disorder

Published online by Cambridge University Press:  24 June 2014

Michel Bourin  and
Eric Dailly
Michel Bourin*
Affiliation:
EA 3256 “Neurobiologie de l'Anxiété et de la Dépression”, Faculté de Médecine, Nantes cedex 1, France
Eric Dailly
Affiliation:
EA 3256 “Neurobiologie de l'Anxiété et de la Dépression”, Faculté de Médecine, Nantes cedex 1, France
*
Michel Bourin, EA 3256 “Neurobiologie de l'Anxiété et de la Dépression”, Faculté de Médecine, BP 53508, Nantes cedex 1, France. Tel: +33-2-40412852; Fax: +33-2-40412856; E-mail: mbourin@sante.univ-nantes.fr
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Abstract

Evidence for implication of cholecystokinin (CCK) in the neurobiology of panic disorder is reviewed through animal and human pharmacological studies. The results of these investigations raise two issues: (i) selectivity of action of CCK-2 agonists in anxiety disorders; and (ii) aberrations of the CCK system in anxiety disorders, both of which are discussed.

Keywords

anxietycholecystokininpanic disorder
Type
Review Article
Information
Acta Neuropsychiatrica , Volume 16 , Issue 2 , April 2004 , pp. 85 - 93
Copyright
Copyright © 2004 Blackwell Munksgaard

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