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A comprehensive study of oxidative stress in patients with somatic symptom disorder

Published online by Cambridge University Press:  18 December 2018

Esra Kabadayi Sahin ,
Ali Caykoylu ,
Almila Senat  and
Ozcan Erel
Esra Kabadayi Sahin*
Affiliation:
Department of Psychiatry, Abant Izzet Baysal University, Izzet Baysal Mental Health Research and Training Hospital, Bolu, Turkey
Ali Caykoylu
Affiliation:
Department of Psychiatry, Ankara Yildirim Beyazit University Medical School, Ankara, Turkey
Almila Senat
Affiliation:
Department of Biochemistry, Ankara Yildirim Beyazit University Medical School, Ankara, Turkey
Ozcan Erel
Affiliation:
Department of Biochemistry, Ankara Yildirim Beyazit University Medical School, Ankara, Turkey
*
Author for correspondence: Esra Kabadayi Sahin, Abant Izzet Baysal University, Izzet Baysal Mental Health Research and Training Hospital, Alpagut Street, Agaccilar Village, Bolu, Turkey. Tel: +00 90 374 275 25 25; Fax: +00 90 374 275 24 23; E-mail: ekabadayi06@gmail.com
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Abstract

Objective

To investigate oxidative stress parameters [total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), paraoxonase (PON), arylesterase (ARE) and thiol-disulphide homeostasis] in patients who were diagnosed as having somatic symptom disorder in accordance with Diagnostic and Statistical Manual of Mental Disorders-5.

Methods

The study included 41 medication-free patients with somatic symptom disorder and 47 age, sex, and sociodemographic-matched healthy individuals. The patients were administered the Patient Health Questionnaire-15, Somatic Symptom Amplification Scale, Beck Depression Inventory, and Beck Anxiety Inventory. TOS, TAS, OSI, PON, ARE thiol, disulphide levels, and routine biochemical parameters were compared between the two groups.

Results

TOS, OSI, disulphide levels, disulphide/native thiol, and disulphide/total thiol ratios were found significantly higher in the patient group compared with the control group (p < 0.001). There was no significant difference in PON, ARE, and TAS parameters between the two groups (p > 0.05).

Conclusion

This study showed that the level of oxidants increased and oxidative balance was impaired in somatic symptom disorder. Oxidative stress may play a role in the aetiopathogenesis of this disorder. This is the first study to report an association between oxidative stress and somatic symptom disorder.

Keywords

oxidative stressPONSomatic symptom disorderthiol-disulphide homeostasis
Type
Original Article
Information
Acta Neuropsychiatrica , Volume 31 , Issue 2 , April 2019 , pp. 100 - 105
Copyright
© Scandinavian College of Neuropsychopharmacology 2018 

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