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Depression is associated with lower circulating endothelial progenitor cells and increased inflammatory markers

Published online by Cambridge University Press:  24 June 2014

Lu Yang ,
Lie-Min Ruan ,
Hong-Hua Ye ,
Han-Bin Cui ,
Qi-Tian Mu ,
Yan-Ru Lou ,
Yun-Xin Ji ,
Wan-Zhen Li ,
Ding-He Sun  and
Xiao-Bei Chen
Lu Yang
Affiliation:
Department of Psychology, Ningbo First Hospital, Ningbo, Zhejiang, China
Lie-Min Ruan*
Affiliation:
Department of Psychology, Ningbo First Hospital, Ningbo, Zhejiang, China
Hong-Hua Ye
Affiliation:
Department of Cardiology, Ningbo First Hospital, Ningbo, Zhejiang, China
Han-Bin Cui
Affiliation:
Department of Cardiology, Ningbo First Hospital, Ningbo, Zhejiang, China
Qi-Tian Mu
Affiliation:
The Stem Cells Transplantation Center, Ningbo First Hospital, Ningbo, Zhejiang, China
Yan-Ru Lou
Affiliation:
The Stem Cells Transplantation Center, Ningbo First Hospital, Ningbo, Zhejiang, China
Yun-Xin Ji
Affiliation:
Department of Psychology, Ningbo First Hospital, Ningbo, Zhejiang, China
Wan-Zhen Li
Affiliation:
Department of Psychology, Ningbo First Hospital, Ningbo, Zhejiang, China
Ding-He Sun
Affiliation:
The Stem Cells Transplantation Center, Ningbo First Hospital, Ningbo, Zhejiang, China
Xiao-Bei Chen
Affiliation:
The Stem Cells Transplantation Center, Ningbo First Hospital, Ningbo, Zhejiang, China
*
Professor Lie-Min Ruan, Department of Psychology, Ningbo First Hospital, Ningbo, Zhejiang 315010, China. Tel: 86 574 87085588; Fax: 86 1354787662; E-mail: liemin_ruan@163.com
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Extract

Yang L, Ruan L-M, Ye H-H, Cui H-B, Mu Q-T, Lou Y-R, Ji Y-X, Li W-Z, Sun D-H, Chen X-B. Depression is associated with lower circulating endothelial progenitor cells and increased inflammatory markers.

Objective: To test the hypothesis that depression status in subjects without cardiovascular diseases (CVD) or diabetes is associated with depletion of circulating endothelial progenitor cells (EPCs) and impaired endothelial function.

Method: Thirty depressive persons with the first episode of depression (case group) diagnosed according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) and 30 healthy people (control group) were investigated. The depression status was estimated using Hamilton Rating Scale of Depression from which the criteria of depression are determined to be >21 score. EPCs labeled with CD34-ECD, CD133-phycoerythrin and kinase insert domain receptor (KDR)-fluorescein isothiocyanate antibodies were counted by flow cytometry in the peripheral blood of patients and control subjects. Mononuclear cells that were positive for CD34/KDR, CD133/KDR and CD34/CD133/KDR within the lymphocyte population were characterised as different phenotypes of EPCs.

Results: There were no significant differences in baseline clinical characteristics between patients and healthy individuals (all p > 0.05). However, patients with depression had significantly lower levels of circulating CD34+CD133+KDR+ EPCs (132.20 ± 17.27 vs. 225.93 ± 9.88, p = 0.000) and endothelial colony-forming units (26.40 ± 3.79 vs. 36.60 ± 2.88, p = 0.000) than that of healthy subjects. Furthermore, CD34+CD133+KDR+ EPCs had a negative correlation with tumour necrosis factor-α (Spearman's ρ = 0.433, p = 0.000) and interleukin-6 (Spearman's ρ = 0.441, p = 0.032).

Conclusion: Our result shows that depression was associated with lower levels of circulating EPCs, which may contribute to the development of endothelial dysfunction and atherosclerosis.

Keywords

cardiovascular diseasedepressionendothelial progenitor cellshigh-sensitive C-reactive proteininterleukin-6tumour necrosis factor-α
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 23 , Issue 5 , October 2011 , pp. 235 - 240
Copyright
Copyright © Cambridge University Press 2011

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