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Dynamic magnetic resonance imaging and spectroscopie of experimental brain injury

Published online by Cambridge University Press:  18 September 2015

K. Nicolay ,
R.M. Dijkhuizen ,
A. van der Toorn ,
T. Reese ,
D. Brandsma ,
M. de Boer ,
H.-J. Muller ,
G. van Vliet ,
K.S. Tamminga  and
J.-W. Berkelbach van der Sprenkel
...Show all authors
K. Nicolay*
Affiliation:
Vakgroep in vivo NMR Spectroscopic, Universiteit Utrecht, Bolognalaan 50, 3584 CJ Utrecht
R.M. Dijkhuizen
Affiliation:
Vakgroep in vivo NMR Spectroscopic, Universiteit Utrecht, Bolognalaan 50, 3584 CJ Utrecht Vakgroep Neurochirurgie, Academisch Ziekenhuis Utrecht
A. van der Toorn
Affiliation:
Vakgroep in vivo NMR Spectroscopic, Universiteit Utrecht, Bolognalaan 50, 3584 CJ Utrecht Huidig adres: vakgroep Moleculaire Fysica, Landbouwuniversiteit Wageningen
T. Reese
Affiliation:
Vakgroep in vivo NMR Spectroscopic, Universiteit Utrecht, Bolognalaan 50, 3584 CJ Utrecht
D. Brandsma
Affiliation:
Vakgroep in vivo NMR Spectroscopic, Universiteit Utrecht, Bolognalaan 50, 3584 CJ Utrecht Vakgroep Neurochirurgie, Academisch Ziekenhuis Utrecht
M. de Boer
Affiliation:
Vakgroep in vivo NMR Spectroscopic, Universiteit Utrecht, Bolognalaan 50, 3584 CJ Utrecht
H.-J. Muller
Affiliation:
Vakgroep in vivo NMR Spectroscopic, Universiteit Utrecht, Bolognalaan 50, 3584 CJ Utrecht
G. van Vliet
Affiliation:
Vakgroep in vivo NMR Spectroscopic, Universiteit Utrecht, Bolognalaan 50, 3584 CJ Utrecht
K.S. Tamminga
Affiliation:
Vakgroep in vivo NMR Spectroscopic, Universiteit Utrecht, Bolognalaan 50, 3584 CJ Utrecht Huidig adres: Philips Medical Systems, Best
J.-W. Berkelbach van der Sprenkel
Affiliation:
Vakgroep Neurochirurgie, Academisch Ziekenhuis Utrecht
H.B. Verheul
Affiliation:
Vakgroep Neurochirurgie, Academisch Ziekenhuis Utrecht
C.A.F. Tulleken
Affiliation:
Vakgroep Neurochirurgie, Academisch Ziekenhuis Utrecht
M. van Lookeren Campagne
Affiliation:
Nederlands Instituut voor Hersenonderzoek, Amsterdam
B. M. Spruijt
Affiliation:
Vakgroep Medische Farmacologie, Universiteit Utrecht
*
*Vakgroep in vivo NMR Spectroscopic, Bijvoet Centrum, Universiteit Utrecht, Bolognalaan 50, 3584 CJ Utrecht
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Summary

This article describes the use of non-invasive magnetic resonance (MR) methods for the characterization and monitoring of the pathophysiology of experimental brain injury in laboratory animals as a function of time and treatment. The impact of MR in brain research is primarily due to its non-invasive nature, thereby enabling repeated measurements in long-term studies, and due to the type of information that it provides. MR imaging (MRI) enables the measurement of the morphology/anatomy as well as the functional status of tissues under in vivo conditions. Compared to other in vivo imaging modalities, MRI has a high spatial resolution and allows for a remarkable soft tissue differentiation. MR spectroscopy (MRS) provides information on the biochemical/metabolic status of tissues. MR methods which have proven valuable in animal studies, can be readily translated to the clinical situation where MR-based diagnosis and treatment planning play a rapidly increasing role.

After a short introduction into the principles of MR, we will illustrate the remarkable versatility of MR in research on brain injury from recent animal studies. Examples will be mainly drawn from experiments on early injury in focal cerebral ischemia and from research on mechanical brain trauma and excitotoxic lesions. The article ends with a brief description of the perspectives of MR in neuropsychiatry.

Keywords

Magnetic resonanceimagingspectroscopybrain researchischemiamechanical traumaexcitotoxicityMagnetische resonantiebeeldvormingspectroscopiehersenonderzoekproefdierenischemiemechanisch traumaexcitotoxiciteit
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 8 , Issue 4 , December 1996 , pp. 76 - 86
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1996

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