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Effects of post-training modafinil administration in a discriminative avoidance task in mice

Published online by Cambridge University Press:  23 March 2015

Helaine Arrais Fernandes ,
Karina Agustini Zanin ,
Camilla de Lima Patti ,
Leonardo Brito Lopes-Silva ,
Carolina Souza Bizerra ,
Lia Rita Azeredo Bittencourt ,
Sergio Tufik  and
Roberto Frussa-Filho
Helaine Arrais Fernandes
Affiliation:
Department of Pharmacology, Federal University of São Paulo, SP, Brazil Department of Psychobiology, Federal University of São Paulo, SP, Brazil
Karina Agustini Zanin
Affiliation:
Department of Pharmacology, Federal University of São Paulo, SP, Brazil Department of Psychobiology, Federal University of São Paulo, SP, Brazil
Camilla de Lima Patti*
Affiliation:
Department of Pharmacology, Federal University of São Paulo, SP, Brazil
Leonardo Brito Lopes-Silva
Affiliation:
Department of Pharmacology, Federal University of São Paulo, SP, Brazil Department of Psychobiology, Federal University of São Paulo, SP, Brazil
Carolina Souza Bizerra
Affiliation:
Department of Pharmacology, Federal University of São Paulo, SP, Brazil
Lia Rita Azeredo Bittencourt
Affiliation:
Department of Psychobiology, Federal University of São Paulo, SP, Brazil
Sergio Tufik
Affiliation:
Department of Psychobiology, Federal University of São Paulo, SP, Brazil
Roberto Frussa-Filho
Affiliation:
Department of Pharmacology, Federal University of São Paulo, SP, Brazil Department of Psychobiology, Federal University of São Paulo, SP, Brazil
*
Camilla L. Patti, Departamento de Farmacologia – UNIFESP, Rua Botucatu, 862, Ed. Leal Prado, 1º andar, 04023062, São Paulo, SP, Brazil. Tel/Fax: +55 011 5549 4122; E-mail: camila.patti@unifesp.br; clpatti@gmail.com
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Abstract

Objective

Although the cognitive-enhancing abilities after modafinil have been demonstrated, its effects on memory consolidation remain overlooked. We investigated the effects of repeated modafinil administration on consolidation of a discriminative avoidance task.

Methods

Mice were trained in the plus-maze discriminative avoidance task. After training, mice received intraperitonial modafinil (doses of 32, 64 or 128 mg/kg). Animals were treated for more 9 consecutive days; 30 min after the last injection, testing was performed. In addition, the effects of 32 mg/kg modafinil on consolidation at different time points were examined.

Results

The smaller dose of modafinil (32 mg/kg) impaired memory consolidation, without modifying anxiety or locomotion. Still, modafinil post-training administration at 1 or 2 h impaired memory persistence.

Conclusions

Modafinil impaired memory consolidation in a dose- and time-dependent fashion.

Keywords

anxietylocomotionmemory consolidationmicemodafinil
Type
Short Communications
Information
Acta Neuropsychiatrica , Volume 27 , Issue 4 , August 2015 , pp. 235 - 241
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Copyright
© Scandinavian College of Neuropsychopharmacology 2015 

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Footnotes

*

The first two authors contributed equally to this work.

†

In memoriam.

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