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Evaluation of event-related potentials in Klinefelter syndrome and idiopathic hypogonadotrophic hypogonadism

Published online by Cambridge University Press:  24 June 2014

Umit H. Ulas ,
Erol Bolu ,
Ece Unlu-Alanoglu ,
Yasar Kutukcu ,
M. Fatih Ozdag ,
Zeki Odabasi ,
Metin Ozata ,
S. Yavuz Sanisoglu  and
Okay Vural
Umit H. Ulas*
Affiliation:
Department of Neurology
Erol Bolu
Affiliation:
Department of Endocrinology and Metabolism
Ece Unlu-Alanoglu
Affiliation:
Department of Neurology
Yasar Kutukcu
Affiliation:
Department of Neurology
M. Fatih Ozdag
Affiliation:
Department of Neurology
Zeki Odabasi
Affiliation:
Department of Neurology
Metin Ozata
Affiliation:
Department of Biostatistics, Gulhane Military Medical Academy, Ankara, Turkey
S. Yavuz Sanisoglu
Affiliation:
Department of Biostatistics, Gulhane Military Medical Academy, Ankara, Turkey
Okay Vural
Affiliation:
Department of Neurology
*
Umit Hidir Ulas, MD, Department. of Neurology, Gulhane School of Medicine, Etlik-Ankara 06018, Turkey, Tel: +90 312 304 44 77; Fax: +90 312 304 44 75; E-mail: uhulas@gata.edu.tr
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Abstract

Background:

Many studies have evaluated patients with idiopathic hypogonadothropic hypogonadotropism (IHH), but few of these studies utilize event-related potentials (P300).

Aims:

To assess the cognitive functions of hypergonadotropic vs. hypogonadotropic patients.

Settings and design:

The study group consisted of 41 untreated IHH patients, 32 untreated Klinefelter syndrome (KS) patients, and 30 healthy control subjects.

Methods and material:

In this study, the latency and amplitude of P300 was evaluated in 41 untreated IHH and 32 untreated KS patients and compared to healthy control subjects (average age: 30 years). Also evaluated were the patients' hormone levels.

Results and conclusions:

In this study, the amplitude of P300 was found to be reduced, and the latency prolonged in IHH patients in comparison to KS patients and control subjects. In KS patients, there was no difference in latency of P300, but the amplitude was reduced when compared with the control group. Cognitive dysfunction in patients with hypogonadotropism is related to androgen hormone levels. This deficiency can affect development of the central nervous system (CNS), causing defects of CNS to varying degrees during the perinatal period. Androgen deficiency is considered to exert its effects during the period of cognitive ability development, manifest in IHH patients but not KS patients.

Keywords

event-related potentialsidiopathic hypogonadothropic hypogonadotropismKlinefelter syndrome
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 18 , Issue 1 , February 2006 , pp. 42 - 46
Copyright
Copyright © 2006 Blackwell Munksgaard

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