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Exposure pattern influences the degree of drug-seeking behaviour after withdrawal

Published online by Cambridge University Press:  15 January 2016

Sunghyun In ,
Rong Jie Zhao ,
Hye Ryeong Han ,
Chae Ha Yang ,
Hee Young Kim ,
Young S. Gwak  and
Bong Hyo Lee
Sunghyun In
Affiliation:
Department of Acupuncture, Moxibustion and Acupoint, College of Korean Medicine, Daegu Haany University, Daegu, South Korea
Rong Jie Zhao*
Affiliation:
Department of Pharmacology, Mudanjiang Medical University, Mudanjiang, China
Hye Ryeong Han
Affiliation:
Department of Acupuncture, Moxibustion and Acupoint, College of Korean Medicine, Daegu Haany University, Daegu, South Korea
Chae Ha Yang
Affiliation:
Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu, South Korea
Hee Young Kim
Affiliation:
Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu, South Korea
Young S. Gwak
Affiliation:
Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu, South Korea
Bong Hyo Lee*
Affiliation:
Department of Acupuncture, Moxibustion and Acupoint, College of Korean Medicine, Daegu Haany University, Daegu, South Korea
*
Bong Hyo Lee, Department of Acupuncture, Moxibustion and Acupoint, College of Oriental Medicine, Daegu Haany University, 165 Sang-Dong, Suseong-Gu, Daegu 706-828, South Korea. Tel: +82-53-770-2252; Fax: +82-53-768-6340; E-mail: dlqhdgy@dhu.ac.kr
Bong Hyo Lee, Department of Acupuncture, Moxibustion and Acupoint, College of Oriental Medicine, Daegu Haany University, 165 Sang-Dong, Suseong-Gu, Daegu 706-828, South Korea. Tel: +82-53-770-2252; Fax: +82-53-768-6340; E-mail: dlqhdgy@dhu.ac.kr
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Abstract

Objectives

The occurrence of a relapse during abstinence is an important issue that must be addressed during treatment for drug addiction. We investigated the influence of drug exposure pattern on morphine-seeking behaviour following withdrawal. We also studied the role of the hippocampus in this process to confirm its involvement in drug relapse.

Methods

Male Sprague–Dawley rats that were trained to self-administer morphine (1.0 mg/kg) using 2, 4, 6, 8, or 10 h daily sessions underwent withdrawal in their home cages and were re-exposed to the operant chamber to evaluate morphine-seeking behaviour. During the relapse session, rats were intravenously injected with morphine (0.25 mg/kg) or saline before re-exposure to the chamber. In the second experiment, rats were administered a microinjection of saline or cobalt chloride (CoCl2, 1 mM), a synaptic blocker, into the CA1 of the hippocampus prior to the relapse test.

Results

In the first experiment, more morphine-seeking behaviour was observed in the 2 h group (animals trained to self-administer morphine during a 2 h daily session spread over 21 days) during the relapse session, despite all groups being exposed to similar amounts of morphine during the training period before withdrawal. In the second experiment, pretreatment with CoCl2 markedly reduced morphine-seeking behaviour in the 2 h group.

Conclusions

The present findings suggest that the exposure pattern influences the degree of relapse and that control of memorisation is important for prevention of relapse.

Keywords

hippocampusmemorymorphine-seekingrelapsewithdrawal
Type
Original Articles
Information
Acta Neuropsychiatrica , Volume 28 , Issue 4 , August 2016 , pp. 199 - 205
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Copyright
© Scandinavian College of Neuropsychopharmacology 2016 

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