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The G allele in IL-10-1082 G/A may have a role in lowering the susceptibility to panic disorder in female patients

Published online by Cambridge University Press:  06 June 2016

Han-Joon Kim  and
Yong-Ku Kim
Han-Joon Kim
Affiliation:
Department of Psychiatry, College of Medicine, Korea University, Seoul, Republic of Korea
Yong-Ku Kim*
Affiliation:
Department of Psychiatry, College of Medicine, Korea University, Seoul, Republic of Korea
*
Prof. Dr. Yong-Ku Kim, Department of Psychiatry, Korea University Ansan Hospital, Korea University College of Medicine, 123 Jeokgeum-ro, Danwon-gu, Ansan 152-703, Republic of Korea. Tel: +82-31-412-5138; Fax: +82-31-412-5132; E-mail: yongku@korea.ac.kr
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Abstract

Background

Immune system activation is involved in the pathophysiology of panic disorder (PD). We investigated INF-γ+874 A/T, TNF-α-308 G/A, and IL-10-1082 G/A single nucleotide polymorphisms (SNPs) to determine their association with PD.

Method

This study enroled 135 PD patients and 135 healthy controls. INF-γ+874 A/T (rs2430561), TNF-α-308 G/A (rs1800629), and IL-10-1082 G/A (rs1800896) were genotyped.

Results

There were no differences in genotypes or allele frequencies between the patient and control groups, regardless of accompanying agoraphobia. However, for female patients, the G allele frequency in IL-10 SNP was higher in the control group than in the patient group. Additionally, the female control group had a higher frequency of the A/G and G/G genotype in the IL-10 SNP than the female patient group.

Conclusion

We suggest that the G allele in IL-10-1082 G/A might have a role in reducing the manifestations of PD in female patients. Further studies are needed to extend and confirm our findings.

Keywords

cytokineIFN-rIL-10panic disorderTNF-α
Type
Short Communication
Information
Acta Neuropsychiatrica , Volume 28 , Issue 6 , December 2016 , pp. 357 - 361
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Copyright
© Scandinavian College of Neuropsychopharmacology 2016 

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References

1. Hettema, JM, Neale, MC, Kendler, KS. A review and meta-analysis of the genetic epidemiology of anxiety disorders. Am J Psychiatry 2001;158:1568–1578.Google Scholar
2. Kessler, R. Review: major anxiety disorders all have substantive familial aggregation. Evid Based Ment Health 2002;5:92.CrossRefGoogle ScholarPubMed
3. Myint, AM, Kim, YK. Cytokine-serotonin interaction through IDO: a neurodegeneration hypothesis of depression. Med Hypotheses 2003;61:519–525.Google Scholar
4. Myint, AM, Kim, YK. Network beyond IDO in psychiatric disorders: revisiting neurodegeneration hypothesis. Prog Neuropsychopharmacol Biol Psychiatry 2014;48:304–313.Google Scholar
5. Hoge, EA, Brandstetter, K, Moshier, S, Pollack, MH, Wong, KK, Simon, NM. Broad spectrum of cytokine abnormalities in panic disorder and posttraumatic stress disorder. Depress Anxiety 2009;26:447–455.Google Scholar
6. Brambilla, F, Bellodi, L, Perna, G, Bertani, A, Panerai, A, Sacerdote, P. Plasma interleukin-1 beta concentrations in panic disorder. Psychiatry Res 1994;54:135–142.CrossRefGoogle ScholarPubMed
7. Weizman, R, Laor, N, Wiener, Z, Wolmer, L, Bessler, H. Cytokine production in panic disorder patients. Clinical neuropharmacology 1999;22:107–109.CrossRefGoogle ScholarPubMed
8. van Duinen, MA, Schruers, KR, Kenis, GR et al. Effects of experimental panic on neuroimmunological functioning. J Psychosom Res 2008;64:305–310.CrossRefGoogle ScholarPubMed
9. Yoon, HK, Yang, JC, Lee, HJ, Kim, YK. The association between serotonin-related gene polymorphisms and panic disorder. J Anxiety Disord 2008;22:1529–1534.CrossRefGoogle ScholarPubMed
10. Kim, YK, Lee, HJ, Yang, JC, Hwang, JA, Yoon, HK. A tryptophan hydroxylase 2 gene polymorphism is associated with panic disorder. Behav Genet 2009;39:170–175.Google Scholar
11. Choi, WS, Lee, BH, Yang, JC, Kim, YK. Association study between 5-HT1A receptor gene C(-1019)G polymorphism and panic disorder in a Korean population. Psychiatry Investig 2010;7:141–146.CrossRefGoogle Scholar
12. Lam, P, Cheng, CY, Hong, CJ, Tsai, SJ. Association study of a brain-derived neurotrophic factor (Val66Met) genetic polymorphism and panic disorder. Neuropsychobiology 2004;49:178–181.CrossRefGoogle ScholarPubMed
13. Lam, P, Hong, CJ, Tsai, SJ. Association study of A2a adenosine receptor genetic polymorphism in panic disorder. Neurosci Lett 2005;378:98–101.CrossRefGoogle ScholarPubMed
14. Koido, K, Eller, T, Kingo, K et al. Interleukin 10 family gene polymorphisms are not associated with major depressive disorder and panic disorder phenotypes. J Psychiatr Res 2010;44:275–277.Google Scholar
15. Wilson, AG, Symons, JA, McDowell, TL, McDevitt, HO, Duff, GW. Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci USA 1997;94:3195–3199.Google Scholar
16. Crawley, E, Kay, R, Sillibourne, J, Patel, P, Hutchinson, I, Woo, P. Polymorphic haplotypes of the interleukin-10 5’ flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis. Arthritis Rheum 1999;42:1101–1108.3.0.CO;2-Y>CrossRefGoogle ScholarPubMed
17. Pravica, V, Perrey, C, Stevens, A, Lee, JH, Hutchinson, IV. A single nucleotide polymorphism in the first intron of the human IFN-gamma gene: absolute correlation with a polymorphic CA microsatellite marker of high IFN-gamma production. Hum Immunol 2000;61:863–866.Google Scholar
18. Tso, HW, Ip, WK, Chong, WP, Tam, CM, Chiang, AK, Lau, YL. Association of interferon gamma and interleukin 10 genes with tuberculosis in Hong Kong Chinese. Genes Immun 2005;6:358–363.Google Scholar
19. Chong, WP, Ip, WK, Tso, GH et al. The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome. BMC Infect Dis 2006;6:82.Google Scholar
20. Hoppe, LJ, Ipser, J, Gorman, JM, Stein, DJ. Panic disorder. Handb Clin Neurol 2012;106:363–374.Google Scholar
21. First, M SR, Gibbon, M. Structured Clinical Interview for DSM-IV Axis I Disorder, patient edition. New York State Psychiatric Institute, New York, 1998.Google Scholar
22. Vinasco, J, Beraun, Y, Nieto, A et al. Polymorphism at the TNF loci in rheumatoid arthritis. Tissue Antigens 1997;49:74–78.Google Scholar
23. Edwards-Smith, CJ, Jonsson, JR, Purdie, DM, Bansal, A, Shorthouse, C, Powell, EE. Interleukin-10 promoter polymorphism predicts initial response of chronic hepatitis C to interferon alfa. Hepatology 1999;30:526–530.Google Scholar
24. Bai, J, Lin, M, Zeng, X et al. Association of polymorphisms in the human IFN-gamma and IL-4 gene with oral lichen planus: a study in an ethnic Chinese cohort. J Interferon Cytokine Res 2008;28:351–358.Google Scholar
25. Paul-Samojedny, M, Kowalczyk, M, Suchanek, R et al. Functional polymorphism in the interleukin-6 and interleukin-10 genes in patients with paranoid schizophrenia--a case-control study. J Mol Neurosci 2010;42:112–119.Google Scholar
26. Omrani, MD, Bushehri, B, Bagheri, M et al. Role of IL-10-1082, IFN-gamma +874, and TNF-alpha -308 genes polymorphisms in suicidal behavior. Arch Suicide Res 2009;13:330–339.Google Scholar
27. Kim, YK, Hong, JP, Hwang, JA et al. TNF-alpha -308G>A polymorphism is associated with suicide attempts in major depressive disorder. J Affect Disord 2013;150:668–672.Google Scholar
28. Wust, S, Kumsta, R, Treutlein, J et al. Sex-specific association between the 5-HTT gene-linked polymorphic region and basal cortisol secretion. Psychoneuroendocrinology 2009;34:972–982.Google Scholar
29. Dell’Osso, L, Marazziti, D, Da Pozzo, E et al. Gender effect on the relationship between stress hormones and panic-agoraphobic spectrum dimensions in healthy subjects. CNS Spectrums 2012;17:214–220.CrossRefGoogle ScholarPubMed
30. Traks, T, Koido, K, Eller, T et al. Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder. BMC Med Genet 2008;9:111.CrossRefGoogle ScholarPubMed
31. Weiss, G, Murr, C, Zoller, H et al. Modulation of neopterin formation and tryptophan degradation by Th1-and Th2-derived cytokines in human monocytic cells. Clin Exp Immunol 1999;116:435–440.Google Scholar
32. Tukel, R, Arslan, BA, Ertekin, BA et al. Decreased IFN-gamma and IL-12 levels in panic disorder. J Psychosom Res 2012;73:63–67.Google Scholar