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Is cognitive behavioural therapy an effective complement to antidepressants in adolescents? A meta-analysis

Published online by Cambridge University Press:  24 June 2014

Raffaella Calati ,
Laura Pedrini ,
Sara Alighieri ,
Mariela Ivana Alvarez ,
Lorenzo Desideri ,
Daniele Durante ,
Federica Favero ,
Luisa Iero ,
Giulia Magnani  and
Valentina Pericoli
...Show all authors
Raffaella Calati
Affiliation:
Institute of Psychiatry, University of Bologna, Bologna, Italy
Laura Pedrini
Affiliation:
IRCCS Centro S. Giovanni di Dio Fatebenefratelli, Brescia, Italy
Sara Alighieri
Affiliation:
N.P.E.E., Rimini AUSL, Rimini, Italy
Mariela Ivana Alvarez
Affiliation:
Children and Adolescent Psychiatry Unit, Reggio Emilia AUSL, Reggio Emilia, Italy
Lorenzo Desideri
Affiliation:
Department of Mental Health, Children and Adolescent Psychiatry Unit, AUSL Bologna, Bologna, Italy
Daniele Durante
Affiliation:
N.P.E.E., Parma AUSL, Parma, Italy
Federica Favero
Affiliation:
Children and Adolescent Psychiatry Unit, Modena AUSL, Sassuolo, Italy
Luisa Iero
Affiliation:
Child Neurology and Psychiatry Unit, Department of Neurological Sciences, University of Bologna, Bologna, Italy
Giulia Magnani
Affiliation:
Department of Mental Health, Children and Adolescent Psychiatry Unit, AUSL Bologna, Bologna, Italy Department of Mental Health, Children and Adolescent Psychiatry Unit, Imola AUSL, Imola, Italy
Valentina Pericoli
Affiliation:
Children and Adolescent Psychiatry Unit, Ravenna AUSL, Ravenna, Italy
Alexia Polmonari
Affiliation:
Children and Adolescent Psychiatry Unit, Ferrara AUSL, Ferrara, Italy
Roberta Raggini
Affiliation:
Children and Adolescent Psychiatry Unit, AUSL Forlì, Forlì, Italy
Elena Raimondi
Affiliation:
Department of Mental Health, Children and Adolescent Psychiatry Unit, AUSL Bologna, Bologna, Italy
Valentina Riboni
Affiliation:
Children and Adolescent Psychiatry Unit, Piacenza AUSL, Piacenza, Italy
Maria Cristina Scaduto
Affiliation:
Child Neurology and Psychiatry Unit, Department of Neurological Sciences, University of Bologna, Bologna, Italy
Alessandro Serretti*
Affiliation:
Institute of Psychiatry, University of Bologna, Bologna, Italy
Giovanni De Girolamo
Affiliation:
IRCCS Centro S. Giovanni di Dio Fatebenefratelli, Brescia, Italy
*
Alessandro Serretti, MD, PhD, Institute of Psychiatry, University of Bologna, Viale Carlo Pepoli 5, 40123 Bologna, Italy. Tel: +39 051 6584233; Fax: +39 051 521030; E-mail: alessandro.serretti@unibo.it
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Abstract

Calati R, Pedrini L, Alighieri S, Alvarez MI, Desideri L, Durante D, Favero F, Iero L, Magnani G, Pericoli V, Polmonari A, Raggini R, Raimondi E, Riboni V, Scaduto MC, Serretti A, De Girolamo G. Is cognitive behavioural therapy an effective complement to antidepressants in adolescents? A meta-analysis.

Objective: Evidence on effectiveness of combined treatments versus antidepressants alone in adolescents consists on a few studies in both major depressive and anxiety disorders. A meta-analysis of randomised 12-week follow-up studies in which antidepressant treatment was compared to combined treatment consisting of the same antidepressant with cognitive behavioural therapy has been performed.

Methods: Data were entered into the Cochrane Collaboration Review Manager software and were analysed within a random effect framework. A quality assessment has been performed through Jadad Scale.

Results: Higher global functioning at the Children's Global Assessment Scale was found in the combined treatment group (p < 0.0001) as well as higher improvement at the Clinical Global Impressions Improvement Scale (p = 0.04). No benefit of combined treatment was found on depressive symptomatology at the Children's Depression Rating Scale – Revised.

Conclusion: Combined treatment seems to be more effective than antidepressant alone on global functioning and general improvement in adolescents with major depressive and anxiety disorders.

Keywords

affective disorderantidepressantsanxietydepressionpsychotherapy
Type
Review Article
Information
Acta Neuropsychiatrica , Volume 23 , Issue 6 , December 2011 , pp. 263 - 271
Copyright
Copyright © Cambridge University Press 2011

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