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Klinefelter syndroom en psychiatrische stoornissen: Twee gevalsbeschrijvingen en een literatuuroverzicht

Published online by Cambridge University Press:  18 September 2015

P.J.S. Michielsen ,
W.M.A. Verhoeven  and
C.V. de Blécourt
P.J.S. Michielsen
Affiliation:
Respectievelijk arts-assistent, zenuwarts/A-opleider en psychiater/plaatsvervangend A-opleider bij het Vincent van Gogh Instituut voor Psychiatrie, Venray
W.M.A. Verhoeven*
Affiliation:
Respectievelijk arts-assistent, zenuwarts/A-opleider en psychiater/plaatsvervangend A-opleider bij het Vincent van Gogh Instituut voor Psychiatrie, Venray Bijzonder hoogleraar Faculteit der Geneeskunde en Gezondheidswe-tenschappen, Erasmus Universiteit, Rotterdam
C.V. de Blécourt
Affiliation:
Respectievelijk arts-assistent, zenuwarts/A-opleider en psychiater/plaatsvervangend A-opleider bij het Vincent van Gogh Instituut voor Psychiatrie, Venray
*
Vincent van Gogh Instituut voor Psychiatrie, Stationsweg 46, 5803 AC Venray, The Netherlands
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Summary

Klinefelter syndrome is a genetically determined disorder characterized by an additional X-chromosome. Apart from the phenotypical features, the literature about this disorder mentiones a psychopathological phenotype comprising mainly psychoses, depressive diseases and personality disorders. A substantial number of patients presents with mild to moderate mental retardation.

In this paper, two case reports are described and their psychopathology is compared with the data from the existing literature.

Keywords

Klinefelter syndromepsychopathological phenotype
Type
Articles
Information
Acta Neuropsychiatrica , Volume 13 , Issue 1 , March 2001 , pp. 15 - 20
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 2001

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References

Literatuur

1.Klinefelter, HF. Reifenstein, EC. Albright, F. Syndrome characterised by gynecomastia aspermatogenesis without A-Leidigism and increased excretion of follicle stimulating hormone. J Clin Endocrinol 1942:2:615–627.CrossRefGoogle Scholar
2.Jacobs, PA. Strong, JA. A case of human intersexuality having a possible XXY sex-determining mechanism. Nature 1959:183:302–303.CrossRefGoogle ScholarPubMed
3.Mandoki, MW. Sumner, GS. Hoffmann, RP. Ricanda, DL. A review of Klinefelter?s Syndrome in Children and Adolescents. J Am Acad Child Adolesc Psychiatry 1991:30:167–172.CrossRefGoogle ScholarPubMed
4.Ingerslev, C. Kreiborg, S. Craniofacial morphology in Klinefelter syndrome: A roentgencephalometric investigation. Cleft Palate J 1978:15:100–108.Google Scholar
5.Ratcliffe, SG. Bancroft, J.Axworthy, D. McLaren, W. Klinefelter's syndrome in adolescence. Arch Dis Child 1982:57:6–12.Google ScholarPubMed
6.Wilson, JD. Griffin, JE. Disorders of sexual differentiation. In: Harrison, TR. Faucv, AS (eds). Harrison's principles of internal medicine. McGraw-Hill. New York. 1997.2119–2123.Google Scholar
7.Theilgaard, A. A psychological study of the personalities of XYY-and XXY-men. Acta Psychiatr Scand 1984:(suppl.315)69:1–133.Google Scholar
8.Forssman, H. The mental implications of sex chromosome aberrations. Br J Psychiatry 1970:117:353–363.CrossRefGoogle ScholarPubMed
9.Robinson, A. Bender, B. Borelli, J. Winter, JS. Sex chromosome aneuploidy: prospective and longitudinal studies: In: Ratcliffe, SG. Paul, N (eds). Birth Defects: Original Article Series. New York. Alan R Liss Inc. 1986:22:23–71.Google Scholar
10.Walzer, S. Bashir, AS.Silberl, AR. Cognitive and behavioral factors in the learning disabilities of 47.XXY and 47.XYY boys. In: Evans, JA. Hamerton, JL. Robinson, A (eds). Children and young adults with sex chromosome aneuploidy. Follow-up. clinical and molecular studies. March of dimes Birth defects foundation. Birth Defects: Original Article Series. New York. Wiley-Liss. 1991:26:45–58.Google Scholar
11.Rovet, J. Netley, C. Bailey, J. Kecman, M. Stewart, D. Intelligence and achievement in children with extra X aneuploidy: a longitudinal perspective. Am J Med Genel/Neuropsychiatr Gen 1995:60:356–363.CrossRefGoogle ScholarPubMed
12.Rovet, J. Netley, C. Keenan, M. Bailey, J. Stewart, D. The psychoeducational profile of bovs with Klinefelter Svndrome. J Learning Disabilities 1996:29:180–196.CrossRefGoogle Scholar
13.Stewart, DA. Bailey, JD. Netley, CT. Rovet, JF. Park, ME. Growth and development from early to midadolescence of children with X and Y chromosome aneuploidy:ThcToronto study. In: Ratcliffe, SG. Paul, N (eds). Birth defects: Original Article Series. New York. Alan R Liss Inc. 1986:22:119–182.Google Scholar
14.Netlev, C. Personality in 47.XXY males during adolescence. Clin Genet 1991:39:409–418.CrossRefGoogle Scholar
15.Hambert, G. Psychiatric symptoms in males with chromatin positive Klinefelter's syndrome. Acta Psychiatr Scand 1964:40S:101–140.CrossRefGoogle Scholar
16.Nielsen, J. Sorenson, A. Theilgaard, A. Froland, A. Johnson, SG. A psychiatric psychological study of 50 severely hypogonadal male patients, including 34 with Klinefelter's syndrome. 47. XXY. Acta Jutlandica Copenhagen. Denmark: University of Aarhus. 1969. 1–183.Google Scholar
17.Kvale, JN. Fishman, JR. Psychosocial aspects of Klinefelter's syndrome. JAMA 1965:193:567–572.CrossRefGoogle ScholarPubMed
18.Schiavi, RC. Theilgaard, A. Owen, DR. White, D. Sex chromosome anomalies, hormones and aggressivily. Arch Gen Psychiatry 1984:41:93–99.CrossRefGoogle Scholar
19.Nielsen, J. Poison, B. Follow-up 20 years later of 34 Klinefelter males with karyotype 47.XXY and 16 hypogonadal males with karyotype 46.XY. Hum Genet 1987:77:188–192.CrossRefGoogle Scholar
20.Nyhan, WL. Behavioural phenotypes in organic genetic disease. Presidential address to the Society of Pediatric Research. Pediatr Res 1972:6:1–9.CrossRefGoogle Scholar
21.Zastowny, TR. Lehman, AF. Dickerson, F. Klinefelter's syndrome and psychopathology: a case study of the combined effects of nature and nurture. Intern J Psychiatr Med 1987:17:155–162.CrossRefGoogle ScholarPubMed
22.Swanson, DW, Stipes, AH. Psychiatric aspects of Klinefelter's svndrome. Am J Psychiatry 1969:126:814–822.CrossRefGoogle Scholar
23.Sorenson, K. Nielsen, J. Twenty psychotic males with Klinefelter's syndrome. Acta Psychiatr Scand 1977:56:249–255.CrossRefGoogle Scholar
24.Mizukami, K. Koizumi, J.Shiraishi, H.Nagase, S. A clinical case of Klinefelter's syndrome with various psychiatric symptoms. Jpn J Psychiatr Neurol 1989:43:639–644.Google ScholarPubMed
25.DeLisi, LE. Friedrich, U. Wahlstrom, J. Boccio-Smith, A. Farsman, A. Eklund, K. Crow, TS. Schizophrenia and sex chromosome anomalies. Schizophr Bull 1994:20:495–505.CrossRefGoogle ScholarPubMed
26.Crow, TJ. DeLisi, LE. Lofthouse, R. Poulter, M. Lehner T., Bass, N. Shah, T. Alsh, C. Boccio-Smith, A. Shields, G. Otl, J. An examination of link-ago of schizophrenia and schizoaffective disorder to the pseudoautosomal region. Br J Psychiatry 1994:164:159–164.CrossRefGoogle Scholar
27.Pinabel, F.Gorwood, P. Ados, J. The impact of oestradiol on ages at onset in schizophrenia reevaluated through Klinefelter svndrome. Schizophr Res 1997:23:269–270.CrossRefGoogle Scholar
28.Warwick, MM. Doody, GA. Lawrie, SM. Kestelman, JN. Best, JJK. Johnstone, EC. Volumetric magnetic resonance imaging study of the brain in subjects with sex chromosome aneuploidies. J Neurol Neurosurg Psychiatry 1999:66:628–632.CrossRefGoogle ScholarPubMed
29.Bender, BG. Harmon, RJ. Linden, MG. Robinson, A. Psychosocial adaptation of 39 adolescents with sex chromosome abnormalities. Pediatrics 1995:96:302–308.CrossRefGoogle ScholarPubMed
30.Nielsen, J. Chromosome examination of male patients in a psychiatric hospital. Br J Psychiatry 1975:127:404–406.CrossRefGoogle ScholarPubMed
31.Hambert, G. Males with positive sex chromatin. Reports from the psychiatric research center. St. Jorgen's hospital. University of Goleborg. Sweden and Munksgaard. Copenhagen. Denmark 1966.Google Scholar
32.Casey, MD. Blank, CI. McLean, TM. Kohn, P. Street, DRK. McDougal, JM. Gooder, J. Platts, J. Male patients with chromosome abnormality in two stale hospitals. J Ment Do fie Res 1972:16:215–256.Google Scholar
33.Nielsen, J. Wohlert, M. Sorenson, K. Follow-up of 30 Klinefelter males treated with testosterone. Clin Genet 1988:33:262–269.CrossRefGoogle ScholarPubMed