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Neuropeptides and anxiety disorders

Published online by Cambridge University Press:  18 September 2015

H.J.G.M. van Megen ,
J.A. den Boer  and
H.G.M. Westenberg
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Summary

In this review article four neuropeptides: adrenocorticotrope hormone (ACTH), corticotrope releasing hormone (CRH), neuropeptide- Y(NPY) and cholecystokinin (CCK) are discussed with respect to their possible role in the pathogenesis of anxiety disorders. First the presumable working mechanism of these peptides in the brain is mentioned. In addition, the relationship of these peptides and anxiety is outlined using neuroanatomical and electrophysiological research data. Subsequently, animal experiments and human research findings are discussed. Most of the research findings so far are obtained from animal data. Only with respect to CCK, there is increasing evidence, also from human studies, that this peptide might play a role in the pathogenesis of anxiety disorders. The putative role of the other peptides remains to be estab lished in future research.

Keywords

anxiety disordersneuropeptidesACTHCRHNPYCCKangststoornissenneuropeptidenACTHCRHNPYCCK
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 4 , Issue 2 , June 1992 , pp. 25 - 30
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1992

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