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Peripheral interleukin-6 promotes resilience versus susceptibility to inescapable electric stress

Published online by Cambridge University Press:  28 May 2015

Chun Yang ,
Yukihiko Shirayama ,
Ji-Chun Zhang ,
Qian Ren  and
Kenji Hashimoto
Chun Yang
Affiliation:
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
Yukihiko Shirayama
Affiliation:
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan Department of Psychiatry, Teikyo University Chiba Medical Center, Ichihara, Japan
Ji-Chun Zhang
Affiliation:
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
Qian Ren
Affiliation:
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
Kenji Hashimoto*
Affiliation:
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
*
Dr. Kenji Hashimoto, Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba 260-8670, Japan. Tel: +81 43 226 2517; Fax: +81 43 226 2561; E-mail: hashimoto@faculty.chiba-u.jp
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Abstract

Objective

Accumulating evidences suggest that pro-inflammatory cytokines such as interleukin-6 (IL-6) play a role in the pathophysiology of depression. In the learned helplessness (LH) paradigm, ~35% rats are resilient to inescapable stress.

Methods

Levels of IL-6 in the serum and medial prefrontal cortex (mPFC) of LH rats (susceptible) and non-LH rats (resilience) were measured using enzyme-linked immunosorbent assay and western blot analysis, respectively.

Results

Serum levels of IL-6 in the LH rats were significantly higher than those of control and non-LH rats. In contrast, tissue levels of IL-6 in the mPFC were not different among three groups.

Conclusion

The results suggest that peripheral IL-6 may contribute to resilience versus susceptibility to inescapable stress.

Keywords

interleukin-6 (IL-6)learned helplessnessresiliencesusceptible
Type
Short Communications
Information
Acta Neuropsychiatrica , Volume 27 , Issue 5 , October 2015 , pp. 312 - 316
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Copyright
© Scandinavian College of Neuropsychopharmacology 2015 

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References

1. Feder, A, Nestler, EJ, Charney, DS. Psychobiology and molecular genetics of resilience. Nat Rev Neurosci 2009;10:446–457.CrossRefGoogle ScholarPubMed
2. Russo, SJ, Murrough, JW, Han, MH, Charney, DS, Nestler, EJ. Neurobiology of resilience. Nat Neurosci 2012;15:1475–1484.CrossRefGoogle ScholarPubMed
3. Southwick, SM, Vythilingam, M, Charney, DS. The psychobiology of depression and resilience to stress: implications for prevention and treatment. Annu Rev Clin Psychol 2005;1:255–291.CrossRefGoogle ScholarPubMed
4. Yang, C, Shirayama, Y, Zhang, JC, Ren, Q, Hashimoto, K. Regional differences in brain-derived neurotrophic factor and dendritic spine density confer resilience to inescapable stress. Int J Neuropsychopharmacol 2015;18:pyu121.Google Scholar
5. Dantzer, R, O’Connor, JC, Freund, GG, Johnson, RW, Kelly, KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 2008;9:46–57.CrossRefGoogle ScholarPubMed
6. Raison, CL, Lowry, CA, Rook, GA. Inflammation, sanitation, and consternation: loss of contact with coevolved, tolerogenic microorganisms and the pathophysiology and treatment of major depression. Arch Gen Psychiatry 2010;67:1211–1224.Google Scholar
7. Young, JJ, Bruno, D, Pomara, N. A review of the relationship between proinflammatory cytokines and major depressive disorder. J Affect Disord 2014;169:15–20.Google Scholar
8. Dowlati, Y, Herrmann, N, Swardfager, W et al. A meta-analysis of cytokines in major depression. Biol Psychiatry 2010;67:446–457.Google Scholar
9. Black, C, Miller, BJ. Meta-analysis of cytokines and chemokines in suicidality: distinguishing suicidal versus nonsuicidal patients. Biol Psychiatry 2015; doi: 10.1016/j.biopsych.2014.10.014 [Epub ahead of print].Google Scholar
10. Muneoka, K, Shirayama, Y, Horio, M, Iyo, M, Hashimoto, K. Differential levels of brain amino acids in rat models presenting learned helplessness or non-learned helplessness. Psychopharmacology 2013;226:63–71.Google Scholar
11. Shirayama, Y, Muneoka, K, Fukumoto, M et al. Infusions of allopregnanolone into the hippocampus and amygdala, but not into the nucleus accumbens and medial prefrontal cortex, produce antidepressant effects on the learned helplessness rats. Hippocampus 2011;21:1105–1113.Google Scholar
12. Hodes, GE, Pfau, ML, Leboeuf, M et al. Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress. Proc Natl Acad Sci USA 2014;111:16136–16141.CrossRefGoogle ScholarPubMed
13. Yang, JJ, Wang, N, Yang, C, Shi, JY, Yu, HY, Hashimoto, K. Serum interleukin-6 is a predictive biomarker for ketamine’s antidepressant effect in treatment-resistant patients with major depression. Biol Psychiatry 2015;77:e19–e20.Google Scholar
14. Virtanen, M, Shipley, MJ, Batty, DG et al. Interleukin-6 as a predictor of symptom resolution in psychological distress: a cohort study. Psychol Med 2015;20:1–8. [Epub ahead of print].Google Scholar
15. Agudelo, LZ, Femenia, T, Orhan, F et al. Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression. Cell 2014;159:33–45.Google Scholar
16. Schwarcz, R, Bruno, JP, Muchowski, PJ, Wu, HQ. Kynurenines in the mammalian brain: when physiology meets pathology. Nat Rev Neurosci 2012;13:465–477.CrossRefGoogle ScholarPubMed
17. Hashimoto, K. Inflammatory biomarkers as differential predictors of antidepressant response. Int J Mol Sci 2015;16:7796–7801.Google Scholar
18. Shetty, A, Hanson, R, Korsten, P et al. Tocilizumab in the treatment of rheumatoid arthritis and beyond. Drug Des Dev Ther 2014;8:349–364.Google ScholarPubMed