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Pharmacotherapeutical treatment of personality disorders*

Published online by Cambridge University Press:  18 September 2015

J.M. Keppel Hesselink
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Summary

Since some years it has become evident that objective disturbances can be found in patients suffering from personality disorders. Research findings from earlier date already demonstrated low levels of 5-hydroxyindoleacetic acid in the cerebrospinal fluid, especially in patients with personality disorders, under exclusion of depressive features. Furthermore, data have been collected on the correlation between a hyposerotonergic state and disturbances in aggression and impulse control in a variety of syndromes such as automutilation, bulimia nervosa, suicide attempts and various states of drug abuse.

However, psychopharmacological research in personality disorders is rare and to date mainly patients with borderline and schizotypical personality disorders have been studied. It is quite remarkable for this area to find more review articles than original contributions based on the results of clinical trials. A great variety of recommendations for pharmacotherapy in these patients exists in literature, among which treatment with carbamazepine, lithium, low-dose neuroleptics, tricyclic antidepressants and serotonin uptake inhibitors. In this article we will analyze the research methodology and the results of clinical trials forming the base for pharmacotherapeutic treatment recommendations.

Only the results of well-controlled studies will be reviewed.

Keywords

clinical trialsdouble-blindplaceboreviewpersonality disorderspsychopharmacologytreatmentimpulse controlserotoninazapironesklinisch geneesmiddelenonderzoekdubbel-blindplacebopersoonlijkheidsstoornissenoverzichtpsychofarmacologiebehandelingimpuls-stoornissenSerotonineazapironen
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 7 , Issue 3 , September 1995 , pp. 80 - 83
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1995

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Footnotes

*

Dit artikel is een uitbreiding van een voordracht gehouden in het Vincent van Gogh Instituut op 18-11-1994: ‘De farmacotherapeutische behandeling van persoonlijkheidsstoornissen; mogelijke rol van serotonerge farmaca in het algemeen en de azapironen in het bijzonder.’

References

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