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Putting the brain in Jeopardy: a novel comprehensive and expressive language task?

Published online by Cambridge University Press:  24 June 2014

Erik Magnus Berntsen ,
Inge-Andre Rasmussen ,
Petter Samuelsen ,
Jian Xu ,
Olav Haraldseth ,
Jim Lagopoulos  and
Gin S. Malhi
Erik Magnus Berntsen
Affiliation:
Department of Circulation and Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Inge-Andre Rasmussen
Affiliation:
Department of Circulation and Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Petter Samuelsen
Affiliation:
Department of Circulation and Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Jian Xu
Affiliation:
Department of Circulation and Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Olav Haraldseth
Affiliation:
Department of Circulation and Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Jim Lagopoulos
Affiliation:
School of Psychiatry, University of New South Wales, Sydney, Australia Mayne Clinical Research Imaging Center, Sydney, Australia Neuroscience Research Group, Mood Disorders Unit, Black Dog Institute, Prince of Wales Hospital, Sydney, Australia
Gin S. Malhi*
Affiliation:
School of Psychiatry, University of New South Wales, Sydney, Australia Mayne Clinical Research Imaging Center, Sydney, Australia Neuroscience Research Group, Mood Disorders Unit, Black Dog Institute, Prince of Wales Hospital, Sydney, Australia
*
Dr Gin S. Malhi, Neuroscience Research Group, Mayne Clinical Research Imaging Center, Prince of Wales Medical Research Institute, Barker Street, Randwick, NSW 2031, Australia. Tel: +61 2 9382 3719; Fax: +61 2 9382 8208; E-mail: g.malhi@unsw.edu.au
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Abstract

Objective:

To develop and test a novel fMRI compatible comprehensive and expressive language task that reliably and predictably activates both Wernicke's and Broca's cortical brain regions, respectively, and has utility for the determination of hemispheric language dominance.

Methods:

Ten healthy men (seven) and women (three) were administered a task based on the television game Jeopardy that was adapted for fMRI presentation. The task was programmed using E-PRIME software and designed to run as an event-related experiment. The study was conducted on 3 T MRI Phillips Intera scanner, and data was anlysed using Brain Voyager QX. All subjects provided written informed consent.

Results:

The Jeopardy task produced robust left hemisphere activation in regions corresponding to Wernicke's and Broca's areas.

Conclusion:

This novel fMRI compatible task (Jeopardy) reliably maps both Broca's and Wernicke's areas with robust hemispheric lateralization. It is potentially useful in language localization studies as it offers advantages over conventional procedures and other fMRI tasks by virtue of being non-invasive and mapping both language areas in one experiment.

Keywords

fMRIlanguage processingneurosurgical planningWernickeBroca
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 18 , Issue 2 , April 2006 , pp. 115 - 119
Copyright
Copyright © 2006 Blackwell Munksgaard

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