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Relation between neuritic plaques and depressive state in Alzheimer's disease

Published online by Cambridge University Press:  24 June 2014

Gerben Meynen ,
Heleen Van Stralen ,
Jan H. Smit ,
Wouter Kamphorst ,
Dick F. Swaab  and
Witte J.G. Hoogendijk
Gerben Meynen
Affiliation:
Netherlands Institute for Neuroscience, an Institute of the KNAW, Amsterdam, The Netherlands Department of Psychiatry, NCA, CNCR, VU University Medical Centre, Amsterdam, The Netherlands
Heleen Van Stralen
Affiliation:
Department of Psychiatry, NCA, CNCR, VU University Medical Centre, Amsterdam, The Netherlands
Jan H. Smit
Affiliation:
Department of Psychiatry, NCA, CNCR, VU University Medical Centre, Amsterdam, The Netherlands
Wouter Kamphorst
Affiliation:
Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
Dick F. Swaab
Affiliation:
Netherlands Institute for Neuroscience, an Institute of the KNAW, Amsterdam, The Netherlands
Witte J.G. Hoogendijk*
Affiliation:
Department of Psychiatry, NCA, CNCR, VU University Medical Centre, Amsterdam, The Netherlands
*
Witte J.G. Hoogendijk, Department of Psychiatry, VU University Medical Centre, A.J. Ernststraat 887, 1081 HL Amsterdam, The Netherlands. Tel: +31654395575; Fax: +3120-6737458; E-mail: w.hoogendijk@ggzingeest.nl
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Abstract

Meynen G, Van Stralen H, Smit JH, Kamphorst W, Swaab DF, Hoogendijk WJG. Relation between neuritic plaques and depressive state in Alzheimer's disease.

Background:

To investigate for the first time in a prospective study the relationship between depressive state and the neuropathological hallmarks of Alzheimer's disease, using a scale for depressive symptoms in dementia, while controlling for clinical severity of dementia.

Method:

Within the framework of a prospective longitudinal study of depression in Alzheimer's disease, patients with dementia underwent a clinical evaluation every six months during the last years of their lives, using the Cornell scale for depression in dementia to assess depressive symptoms and using the Functional Assessment Staging scale to control for clinical severity of dementia. The brains of 43 Alzheimer patients were obtained. The last clinical evaluations prior to death together with post-mortem neuropathology measures were analysed.

Results:

We found a correlation between the Cornell scores and the sum score for the density of neuritic plaques in the entire cortex (p = 0.027), and even stronger in the temporal cortex (p = 0.012). The observed correlations were independent of sex, age of death, clinical dementia severity and duration of Alzheimer's disease.

Conclusions:

This study shows a positive relationship between depressive state at time of death and the presence of neuritic plaques in Alzheimer's disease, which is independent of the clinical severity of dementia.

Keywords

Alzheimer's diseasedepressive disordermood disorderneuritic plaquesneuropathologypost-mortem
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 22 , Issue 1 , February 2010 , pp. 14 - 20
Copyright
Copyright © 2009 John Wiley & Sons A/S

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References

Lyketsos, CG, Olin, J.Depression in Alzheimer's disease: overview and treatment. Biol Psychiatry 2002;52:243–252. CrossRefGoogle ScholarPubMed
Broe, GA, Henderson, AS, Creasey, Het al. A case-control study of Alzheimer's disease in Australia. Neurology 1990;40: 1698–1707. CrossRefGoogle ScholarPubMed
Berger, AK, Fratiglioni, L, Forsell, Yet al. The occurrence of depressive symptoms in the preclinical phase of AD: a population-based study. Neurology 1999;53: 1998–2002. CrossRefGoogle ScholarPubMed
Chen, P, Ganguli, M, Mulsant, BHet al. The temporal relationship between depressive symptoms and dementia: a community-based prospective study. Arch Gen Psychiatry 1999;56: 261–266. CrossRefGoogle ScholarPubMed
Saez-Fonseca, JA, Lee, L, Walker, Z.Long-term outcome of depressive pseudodementia in the elderly. J Affect Disord 2007;101: 123–129. CrossRefGoogle ScholarPubMed
Reding, M, Haycox, J, Blass, J.Depression in patients referred to a dementia clinic. A three-year prospective study. Arch Neurol 1985;42: 894–896. CrossRefGoogle Scholar
Kral, VA, Emery, OB.Long-term follow-up of depressive pseudodementia of the aged. Can J Psychiatry 1989;34: 445–446. CrossRefGoogle ScholarPubMed
Devanand, DP, Sano, M, Tang, MXet al. Depressed mood and the incidence of Alzheimer's disease in the elderly living in the community. Arch Gen Psychiatry 1996;53: 175–182. CrossRefGoogle ScholarPubMed
Wilson, RS, Barnes, LL, Mendes de Leon CF et al. Depressive symptoms, cognitive decline, and risk of AD in older persons. Neurology 2002;59: 364–370. CrossRefGoogle ScholarPubMed
Green, RC, Cupples, LA, Kurz, Aet al. Depression as a risk factor for Alzheimer disease: the MIRAGE Study. Arch Neurol 2003;60: 753–759. CrossRefGoogle ScholarPubMed
Ownby, RL, Crocco, E, Acevedo, Aet al. Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis. Arch Gen Psychiatry 2006;63: 530–538. CrossRefGoogle ScholarPubMed
Ott, BR, Fogel, BS.Measurement of depression in dementia: self vs clinician ratin. Int J Geriatr Psychiatry 1992;7: 899–904. CrossRefGoogle Scholar
Antonijevic, IA.Depressive disorders—is it time to endorse different pathophysiologies? Psychoneuroendocrinology 2006;31: 1–15. CrossRefGoogle ScholarPubMed
Bao, AM, Meynen, G, Swaab, DF.The stress system in depression and neurodegeneration: Focus on the human hypothalamus. Brain Res Rev 2008;57: 531–553. CrossRefGoogle ScholarPubMed
Raadsheer, FC, Hoogendijk, WJ, Stam, FCet al. Increased numbers of corticotropin-releasing hormone expressing neurons in the hypothalamic paraventricular nucleus of depressed patients. Neuroendocrinology 1994;60: 436–444. CrossRefGoogle ScholarPubMed
Meynen, G, Unmehopa, UA, Hofman, MAet al. Relation between corticotropin-releasing hormone neuron number in the hypothalamic paraventricular nucleus and depressive state in Alzheimer's disease. Neuroendocrinology 2007;85: 37–44. CrossRefGoogle ScholarPubMed
Hoogendijk, WJ, Sommer, IE, Pool, CWet al. Lack of association between depression and loss of neurons in the locus coeruleus in Alzheimer disease. Arch Gen Psychiatry 1999;56: 45–51. CrossRefGoogle ScholarPubMed
Hoogendijk, WJ, Feenstra, MG, Botterblom, MHet al. Increased activity of surviving locus ceruleus neurons in Alzheimer's disease. Ann Neurol 1999;45: 82–91. 3.0.CO;2-T>CrossRefGoogle ScholarPubMed
Zubenko, GS, Moossy, J, Kopp, U.Neurochemical correlates of major depression in primary dementia. Arch Neurol 1990;47: 209–214. CrossRefGoogle ScholarPubMed
Gerner, RH, Wilkins, JN.CSF cortisol in patients with depression, mania, or anorexia nervosa and in normal subjects. Am J Psychiatry 1983;140: 92–94. Google ScholarPubMed
Hoogendijk, WJ, Meynen, G, Endert, Eet al. Increased cerebrospinal fluid cortisol level in Alzheimer's disease is not related to depression. Neurobiol Aging 2006;27: 780. CrossRefGoogle Scholar
Rapp, MA, Schnaider-Beeri, M, Grossman, HTet al. Increased hippocampal plaques and tangles in patients with Alzheimer disease with a lifetime history of major depression. Arch Gen Psychiatry 2006;63: 161–167. CrossRefGoogle ScholarPubMed
Rapp, MA, Schnaider-Beeri, M, Purohit, DPet al. Increased neurofibrillary tangles in patients with Alzheimer disease with comorbid depression. Am J Geriatr Psychiatry 2008;16: 168–174. CrossRefGoogle ScholarPubMed
Wilson, RS, Schneider, JA, Bienias, JLet al. Depressive symptoms, clinical AD, and cortical plaques and tangles in older persons. Neurology 2003;61: 1102–1107. CrossRefGoogle ScholarPubMed
Jeste, DV, Meeks, TW, Kim, DSet al. Research agenda for DSM-V: diagnostic categories and criteria for neuropsychiatric syndromes in dementia. J Geriatr Psychiatry Neurol 2006;19: 160–171. CrossRefGoogle ScholarPubMed
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders 3rd edn. Washington DC: American Psychiatric Association, 1987. Google Scholar
Zubenko, GS, Zubenko, WN, McPherson, Set al. A collaborative study of the emergence and clinical features of the major depressive syndrome of Alzheimer's disease. Am J Psychiatry 2003;160: 857–866. CrossRefGoogle ScholarPubMed
Burke, WJ, Rubin, EH, Morris, JCet al. Symptoms of “depression” in dementia of the Alzheimer type. Alzheimer Dis Assoc Disord 1988;2: 356–362. CrossRefGoogle Scholar
Alexopoulos, GS, Abrams, RC, Young, RCet al. Cornell Scale for depression in dementia. Biol Psychiatry 1988;23: 271–284. CrossRefGoogle ScholarPubMed
Leontjevas, R, Van Hooren, S, Mulders, A.The Montgomery-Asberg Depression Rating Scale and the Cornell Scale for Depression in Dementia: a validation study with patients exhibiting early-onset dementia. Am J Geriatr Psychiatry 2009;17: 56–64. CrossRefGoogle ScholarPubMed
McKhann, G, Drachman, D, Folstein, Met al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS- ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34: 939–944. CrossRefGoogle ScholarPubMed
Folstein, MF, Folstein, SE, McHugh, PR.“Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12: 189–198. CrossRefGoogle ScholarPubMed
Reisberg, B, Ferris, SH, De Leon, MJet al. Global Deterioration Scale (GDS). Psychopharmacol Bull 1988;24: 661–663. Google ScholarPubMed
Reisberg, B.Functional assessment staging (FAST). Psychopharmacol Bull 1988;24: 653–659. Google ScholarPubMed
Van De Nes, JA, Kamphorst, W, Ravid, Ret al. Comparison of beta-protein/A4 deposits and Alz-50-stained cytoskeletal changes in the hypothalamus and adjoining areas of Alzheimer's disease patients: amorphic plaques and cytoskeletal changes occur independently. Acta Neuropathol 1998;96: 129–138. CrossRefGoogle ScholarPubMed
Braak, H, Braak, E.Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991;82: 239–259. CrossRefGoogle ScholarPubMed
Liu, RY, Zhou, JN, Hoogendijk, WJet al. Decreased vasopressin gene expression in the biological clock of Alzheimer disease patients with and without depression. J Neuropathol Exp Neurol 2000;59: 314–322. CrossRefGoogle ScholarPubMed
Swaab, DF, Fliers, E, Hoogendijk, WJet al. Interaction of prefrontal cortical and hypothalamic systems in the pathogenesis of depression. Prog Brain Res 2000;126: 369–396. CrossRefGoogle ScholarPubMed
Swaab, DF, Dubelaar, EJ, Hofman, MAet al. Brain aging and Alzheimer's disease;use it or lose it. Prog Brain Res 2002;138: 343–373. CrossRefGoogle ScholarPubMed
Morgan, MD, Mielke, MM, O’Brien, Ret al. Rates of depression in individuals with pathologic but not clinical Alzheimer disease are lower than those in individuals without the disease: findings from the Baltimore Longitudinal Study on Aging (BLSA). Alzheimer Dis Assoc Disord 2007;21: 199–204. CrossRefGoogle Scholar
Herman, JP, Ostrander, MM, Mueller, NKet al. Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axis. Prog Neuropsychopharmacol Biol Psychiatry 2005;29: 1201–1213. CrossRefGoogle ScholarPubMed
Swaab, DF, Bao, AM, Lucassen, PJ.The stress system in the human brain in depression and neurodegeneration. Ageing Res Rev 2005;4: 141–194. CrossRefGoogle ScholarPubMed
Sapolsky, RM.Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch Gen Psychiatry 2000;57: 925–935. CrossRefGoogle ScholarPubMed
Ferketich, AK, Schwartzbaum, JA, Frid, DJet al. Depression as an antecedent to heart disease among women and men in the NHANES I study. National Health and Nutrition Examination Survey. Arch Intern Med 2000;160: 1261–1268. CrossRefGoogle ScholarPubMed
Whooley, MA.Depression and cardiovascular disease: healing the broken-hearted. JAMA 2006;295: 2874–2881. CrossRefGoogle ScholarPubMed
Newman, AB, Fitzpatrick, AL, Lopez, Oet al. Dementia and Alzheimer's disease incidence in relationship to cardiovascular disease in the Cardiovascular Health Study cohort. J Am Geriatr Soc 2005;53: 1101–1107. CrossRefGoogle ScholarPubMed
Raadsheer, FC, Van Heerikhuize, JJ, Lucassen, PJet al. Corticotropin-releasing hormone mRNA levels in the paraventricular nucleus of patients with Alzheimer's disease and depression. Am J Psychiatry 1995;152: 1372–1376. Google ScholarPubMed
Goncharuk, VD, Van, HJ, Swaab, DFet al. Paraventricular nucleus of the human hypothalamus in primary hypertension: activation of corticotropin-releasing hormone neurons. J Comp Neurol 2002;443: 321–331. CrossRefGoogle ScholarPubMed
Thompson, S, Herrmann, N, Rapoport, MJet al. Efficacy and safety of antidepressants for treatment of depression in Alzheimer's disease: a metaanalysis. Can J Psychiatry 2007;52: 248–255. CrossRefGoogle ScholarPubMed
Holsboer, F, Ising, M.Central CRH system in depression and anxiety - Evidence from clinical studies with CRH(1) receptor antagonists. Eur J Pharmacol 2008;583: 350–357. CrossRefGoogle ScholarPubMed