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The role of serotonin in Parkinsons' Disease: An integrated approach for research of motor, cognitive and affective symptoms with functional intervention studies

Published online by Cambridge University Press:  18 September 2015

A.F.G. Leentjens ,
F.R.J. Verhey ,
F.W. Vreeling  and
H.M. van Praag
A.F.G. Leentjens*
Affiliation:
Afdeling Psychiatrie Instituut Hersenen en Gedrag, Universiteit Maastricht
F.R.J. Verhey
Affiliation:
Afdeling Psychiatrie Instituut Hersenen en Gedrag, Universiteit Maastricht
F.W. Vreeling
Affiliation:
Afdeling Neurologie Instituut Hersenen en Gedrag, Universiteit Maastricht
H.M. van Praag
Affiliation:
Afdeling Psychiatrie
*
Academisch Ziekenhuis Maastricht, A.F.G. Leentjens, Postbus 5800, 6202 AZ Maastricht
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Summary

Serotonin seems to play an important role in the regulation of dopaminergic and cholinergic neurotransmitter activities. In patients with Parkinsons' Disease, serotonergic activity is generally reduced, which is considered a compensating mechanism for the reduced dopaminergic activity. At the same time, reduction of serotonin activity may play a role in the expression of cognitive and affective symptoms. Functional intervention with serotonergic agents makes it possible to temporarily enhance or reduce the availability of serotonin in the brain. This will provide the opportunity to study motor, cognitive and affective symptoms in an integrated approach. This type of research has hardly been preformed in patients with Parkinson's Disease.

Keywords

serotonindopaminacetylcholineSleutelwoorden: serotoninedopamineacetylcholine
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 10 , Issue 4 , December 1998 , pp. 84 - 86
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1998

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