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Searching for genes in Schizophrenia

Published online by Cambridge University Press:  18 September 2015

D.B. Wildenauer ,
S.G. Schwab ,
W. Maier  and
B. Lerer
D.B. Wildenauer*
Affiliation:
Molecular Genetics Laboratory, Dept. of Psychiatry, University of Bonn
S.G. Schwab
Affiliation:
Molecular Genetics Laboratory, Dept. of Psychiatry, University of Bonn
W. Maier
Affiliation:
Molecular Genetics Laboratory, Dept. of Psychiatry, University of Bonn
B. Lerer
Affiliation:
Dept. of Psychiatry, Hadassah-Hebrew University Medical Centre, Jerusalem, Israel
*
Molecular, Genetics Laboratory Dept. of Psychiatry, University of Bonn, Wilhelmstr. 31, D-53111 Bonn, Germany
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Extract

Decades of research into the etiology of schizophrenia on a phenotypic level, i.e. studies of neuroanatomy, neuropathology, neurophysiology and other areas such as immunology have yielded only fragmentary results. A contribution of genetic factors, has been consistently shown, however, beginning with E. Kraepelin's pioneering studies at the turn of the century. Evidence has accumulated from family-, twin-, and adoption studies. Identical twins have a 48% risk of developing schizophrenia if one of them is affected. In contrast, a 17 % risk is reported for nonidentical twins. These rates are similar to other complex genetic disorders such as diabetes, hypertension and asthma. Advances in the genetic analysis of complex traits as well as progress in the Human Genome Project should provide a basis for uncovering the molecular causes of schizophrenic disorders and for investigating the neuropathology of this individually and socially devastating neuropsychiatrie disorder. There is no doubt, that discovery of the genetic variation associated with the illness would help in identifying specific targets for development of more effective, targeted treatments.

Keywords

Complex disordergene identification linkagemappingschizophreniasusceptibility genes
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 11 , Issue 2 , June 1999 , pp. 50 - 53
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1999

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References

Literature

1.Leonard, K. Aufteilung der endogenen Psychosen in der Forschungsrichtung von Wernicke und Kleist. Kiskar, KP, Meyer, JE, Müller, M, Strömgen, E, ed. Psychiatrie der Gegenwart Bd II/1 1972: 183–212.Google Scholar
2.Badner, JA, Gershon, ES, Goldin, LR. Optimal ascertainment strategies to detect linkage to common disease alleles. Am J hum Genet 1998;63;880–8.CrossRefGoogle ScholarPubMed
3.Risch, N. Linkage strategies for genetically complex traits II: The power of affected relative pairs. Am J hum Genet 1990;46;229–41.Google ScholarPubMed
4.Spielman, RS, McGinnis, RE, Ewens, WJ. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J med Genet 1993; 52: 506–16.Google ScholarPubMed
5.Schwab, SG, Eckstein, GN, Hallmayer, J, et al.Evidence suggestive of a locus on chromosome 5q31 contributing to susceptibility for schizophrenia in German and Israeli families by multipoint affected sib-pair linkage analysis. Mol Psychiat 1997;2;156–60.CrossRefGoogle ScholarPubMed
6.Straub, RE, MacLean, CJ, O'Neill, FA, et al.Support for a possible schizophrenia vulnerability locus in region 5q22-31 in Irish families. Mol Psychiat 1997;2;148–55.CrossRefGoogle ScholarPubMed
7.Wang, S, Sun, CE, Walczak, CA, et al.Evidence for a susceptibility locus for schizophrenia on chromosome 6pter-p22. Nat Genet 1995;10;41–6.CrossRefGoogle ScholarPubMed
8.Straub, RE, MacLean, CJ, O'Neill, FA, et al.A potential vulnerability locus for schizophrenia on chromosome 6p24-22: evidence for genetic heterogeneity. Nat Genet 1995;11;287–93.CrossRefGoogle ScholarPubMed
9.Schwab, SG, Albus, M, Hallmayer, J, et al.Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib-pair linkage analysis. Nat Genet 1995; 11: 325–7.CrossRefGoogle ScholarPubMed
10.Moises, HW, Yang, L, Kristbjarnarson, H, et al.An international two-stage genome-wide search for schizophrenia susceptibility genes. Nat Genet 1995;11;321–4.CrossRefGoogle ScholarPubMed
11.Antonarakis, SE, Blouin, JL, Pulver, AE, et al.Schizophrenia susceptibility and chromosome 6p24-22. Nat Genet 1995;11;235–6.CrossRefGoogle ScholarPubMed
12.Schizophrenia Linkage Collaborative Group for Chromosomes 3, 6 and 8. Additional support for schizophrenia linkage on chromosomes 6 and 8: a multicenter study. Am J med Genet 1996;67;580–94.3.0.CO;2-P>CrossRefGoogle Scholar
13.Pulver, AE, Lasseter, VK, Kasch, L, et al.Schizophrenia: a genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes. Am J med Genet 1995 60: 252–60.CrossRefGoogle ScholarPubMed
14.Kendler, KS, MacLean, CJ, O'Neill, FA, et al.Evidence for a schizophrenia vulnerability locus on chromosome 8p in the Irish Study of High-Density Schizophrenia Families. Am J Psychiat 1996;153;1534–40.Google ScholarPubMed
15.Faraone, SV, Matise, T, Svrakic, D, et al.Genome scan of European-American schizophrenia pedigrees: results of the NIMH Genetics Initiative and Millennium Consortium. Am J med Genet 1998;81;290–5.3.0.CO;2-Y>CrossRefGoogle ScholarPubMed
16.Straub, RE, MacLean, CJ, Martin, RB, et al.A schizophrenia locus may be located in region 10p15-p11. Am J med Genet 1998;81;296–301.3.0.CO;2-S>CrossRefGoogle ScholarPubMed
17.Schwab, SG, Hallmayer, J, Albus, M, et al.Further evidence for a susceptibility locus on chromosome 10p14-p11 in 72 families with schizophrenia by nonparametric linkage analysis. Am J med Genet 1998;81;302–7.3.0.CO;2-V>CrossRefGoogle ScholarPubMed
18.Rice, JP, Goate, A, Williams, JT, et al.Initial genome scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 1, 6, 8, 10, and 12. Am J med Genet 1997;74;247–53.3.0.CO;2-N>CrossRefGoogle Scholar
19.Blouin, JL, Dombroski, BA, Nath, SK, et al.Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. Nat Genet 1998;20;70–3.CrossRefGoogle ScholarPubMed
20.Lin, MW, Curtis, D, Williams, N, et al.Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32. Psychiat Genet 1995 5: 117–26.CrossRefGoogle ScholarPubMed
21.Berrettini, WH, Ferraro, TN, Goldin, LR, et al.Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene. Proc natl Acad Sci 1994;9;5918–21.CrossRefGoogle Scholar
22.Stine, OC, Xu, J, Koskela, R, et al.Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect. Am J hum Genet 1995;57;1384–94.Google ScholarPubMed
23.Nothen, MM, Cichon, S, Rohleder, H, et al.Evaluation of linkage of bipolar affective disorder to chromosome 18 in a sample of 57 German families. Mol Psychiat 1999;4;76–84.CrossRefGoogle Scholar
24.DeLisi, LE, Lofthouse, R, Lehner, T, et al.Failure to find a chromosome 18 pericentric linkage in families with schizophrenia. Am J med Genet 1995;60;532–4.CrossRefGoogle ScholarPubMed
25.Schwab, SG, Hallmayer, J, Lerer, B, et al.Support for a chromosome 18p locus conferring susceptibility to functional psychoses in families with schizophrenia, by association and linkage analysis. Am J hum Genet 1998;63;1139–52.CrossRefGoogle ScholarPubMed
26.Pulver, AE, Karayiorgou, M, Wolyniec, PS, et al.Sequential strategy to identify a susceptibility gene for schizophrenia: report of potential linkage on chromosome 22q12-q13.1: Part 1. Am J med Genet 1994;54;36–43.CrossRefGoogle ScholarPubMed
27.Coon, H, Holik, J, Hoff, M, et al.Analysis of chromosome 22 markers in nine schizophrenia pedigrees. Am J med Genet 1994;54;72–9.CrossRefGoogle ScholarPubMed
28.Polymeropoulos, MH, Coon, H, Byerley, W, et al.Search for a schizophrenia susceptibility locus on human chromosome 22. Am J med Genet 1994;54;93–9.CrossRefGoogle ScholarPubMed
29.Wildenauer, DB, Hallmayer, J, Schwab, SG, et al.Searching for susceptibility genes in schizophrenia by genetic linkage analysis. Cold Spring Harb Symp Quant Biol 1996;61;845–50.Google ScholarPubMed
30.Schizophrenia Collaborative Linkage Group for Chromosome 22. A transmission disequilibrium and linkage analysis of D22S278 marker alleles in 574 families: further support for a susceptibility locus for schizophrenia at 22q 12. SchizophrRes 1998;32;115–21.Google Scholar