Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-13T02:22:33.023Z Has data issue: false hasContentIssue false
  • English
  • Français

Stress, cortisol and memory as markers of serotonergic vulnerability

Published online by Cambridge University Press:  24 June 2014

Wim J. Riedel ,
Sjacko Sobczak ,
Nancy Nicolson  and
Adriaan Honig
Wim J. Riedel
Affiliation:
Brain & Behaviour Insititue, Dept of Psychiatry & Neuropsychology, Universiteit Maastricht
Sjacko Sobczak
Affiliation:
Brain & Behaviour Insititue, Dept of Psychiatry & Neuropsychology, Universiteit Maastricht
Nancy Nicolson
Affiliation:
Brain & Behaviour Insititue, Dept of Psychiatry & Neuropsychology, Universiteit Maastricht
Adriaan Honig
Affiliation:
Brain & Behaviour Insititue, Dept of Psychiatry & Neuropsychology, Universiteit Maastricht
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

In the present paper the association of stress-induced cortisol with memory impairment is discussed

Methods:

An experiment is described in which an attempt is made to block stress-induced cortisol by lowering 5-HT neurotransmission by means of acute tryptophan depletion (ATD). Forty-five healthy control subjects participated in the experiment.

Results:

Stress-induced peak cortisol and immediate memory performance were negatively associated. ATD tended to block stress-induced cortisol response. ATD also blocked the association between peak cortisol response and memory impairment.

Conclusions:

Stress-induced cortisol and its association with memory impairment is mediated at least partially by serotonin.

Keywords

cortisolmemory performanceserotonin-drug-effects5-HT
Type
Original Article
Information
Acta Neuropsychiatrica , Volume 14 , Issue 4 , August 2002 , pp. 186 - 191
Copyright
Copyright © Blackwell Munksgaard 2002

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Maes, M, Meltzer, HY. The serotonin hypothesis of major depression. In: Bloom, FE, Kupfer, DJ, eds. Psychopharmacology: the fourth generation of progress. New York: Raven Press, 1995: 933–944. Google Scholar
Benkelfat, C, Ellenbogen, MA, Dean, P, Palmour, RM, Young, SN. Mood-lowering effect of tryptophan depletion. Enhanced susceptibility in young men at genetic risk for major affective disorders. Arch Gen Psychiatry 1994;51: 687–697.CrossRefGoogle Scholar
Klaassen, T, Riedel, WJ, Honig, A, Van Someren, A, Deutz, NEP, Van Praag, HM. Mood effects of 24-hour tryptophan depletion in healthy first degree relatives of patients with affective disorders. Biol Psychiatry 1999;46: 489–497.CrossRefGoogle ScholarPubMed
Van Praag, HM. Serotonin related, anxiety/aggression driven, stressor precipitated depression: a psycho-biological hypothesis. Eur Psychiatry 1996;11: 57–67. CrossRefGoogle ScholarPubMed
Stokes, PE. The potential role of excessive cortisol induced by HPA hyperfunction in the pathogenesis of depression. Eur Neuropsychopharmacol 1995;5 (Suppl.):77–82.CrossRefGoogle Scholar
Abel, KM, Cleare, AJ. Peripheral hormonal responses to d-fenfluramine as a probe of central serotonergic function in humans. Psychopharmacology 1999;142: 68–72.CrossRefGoogle ScholarPubMed
Yatham, LN, Steiner, M. Neuroendocrine probes of serotonergic function: a critical review. Life Sci 1993;53: 447–463.CrossRefGoogle ScholarPubMed
van Eck, M, Berkhof, H, Nicolson, N, Sulon, J. The effects of perceived stress, traits, mood states, and stressful daily events on salivary cortisol. Psychosom Med 1996;58: 447–458.CrossRefGoogle Scholar
van Eck, MM, Nicolson, NA, Berkhof, H, Sulon, J. Individual differences in cortisol responses to a laboratory speech task and their relationship to responses to stressful daily events. Biol Psychol 1996;43: 69–84.CrossRefGoogle ScholarPubMed
Sobczak, S, Honig, A, Nicolson, N, Riedel, WJ. Acute tryptophan depletion enhances mood in first-degree relatives of type II bipolar patients but not in first-degree relatives of type I bipolar patients and healthy matched controls. Neuropsychopharmacology 2002, .Google Scholar
Sobczak, S, Riedel, WJ, Booij, L, Aan het Rot, M, Deutz, NEP, Honig, A. Cognition following acute tryptophan depletion: differences between first-degree relatives of bipolar disorder patients and matched healthy control volunteers. Psychol Med 2002;32: 503–515. Google Scholar
Riedel, WJ, Klaassen, T, Deutz, NEP, Van Someren, A, Van Praag, HM. Tryptophan depletion in normal volunteers produces selective impairment in memory consolidation. Psychopharmacology 1999;141: 362–369.CrossRefGoogle ScholarPubMed
Schmitt, JAJ, Jorissen, BL, Sobczak, S, Van Boxtel, MP, Hogervorst, E, Deutz, NE, Riedel, WJ. Tryptophan depletion impairs memory consolidation but improves focussed attention in healthy young volunteers. J Psychopharmacol 2000;14: 21–29.CrossRefGoogle ScholarPubMed
Rubinsztein, J, Rogers, RD, Riedel, WJ, Mehta, MA, Robbins, TW, Sahakian, BJ. Acute dietary tryptophan depletion impairs affective shifting and delayed visual recognition in healthy volunteers. Psychopharmacology 2001;154: 319–326.CrossRefGoogle ScholarPubMed
Endicott, J, Andreasen, NC, Spitzer, RL. Family history-research diagnostic criteria. New York: Biometric Research, New York State Psychiatric Institute. Google Scholar
Sheehan, D, Lecrubier, Y, Junaus, J, Knapp, E, Weiller, E. Mini international neuropsychiatric interview. Tampa FL, University of South Florida. Google Scholar
Hamilton, M. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychiatry 1967;16: 278–296. CrossRefGoogle Scholar
Young, RC, Biggs, JT, Ziegler, VE, Meyer, DA. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 1978;133: 429–435.CrossRefGoogle ScholarPubMed
Arrindell, WA, Ettema, JhM. SCL-90. Een multidimensionele psychopathologie indicator[SCL-90. A multidimensional indicator of psychopathology]. Lisse: Swets and Zeitlinger, 1986. Google Scholar
Depue, RA, Slater, JF, Wolfstetter-Kausch, H, Klein, D, Goplerud, E, Farr, D. A behavioural paradigm for identifying persons at risk for bipolar depressive disorder. a conceptual framework and five validation studies. J Abnorm Psychol 1981;90: 381–437.CrossRefGoogle Scholar
Depue, RA, Kleiman, RM, Davis, P, Hutchinson, M, Krauss, SP. The behavioural high-risk paradigm and bipolar affective disorder, VIII. Serum free cortisol in nonpatient cyclothymic subjects selected by the General Behaviour Inventory. Am J Psychiatry 1985;142: 175–181.Google Scholar
Depue, RA, Krauss, S, Spoont, MR, Arbisi, P. General behaviour inventory identification of unipolar and bipolar affective conditions in a nonclinical university population. J Abnorm Psychol 1989;98: 117–126.CrossRefGoogle Scholar
Klein, DN, Depue, RA, Slater, JF. Inventory identification of cyclothymia. IX. Validation in offspring of bipolar I patients. Arch Gen Psychiatry 1986;43: 441–445.CrossRefGoogle ScholarPubMed
Luteijn, F, Van Der Ploeg, FAE. Manual Groningen Intelligencetest (GIT). Lisse: Swets and Zeitlinger, 1983Google Scholar
Menkes, DB, Coates, DC, Fawcett, JP. Acute tryptophan depletion aggravates premenstrual syndrome. J Affect Disord 1994;32: 37–44.CrossRefGoogle ScholarPubMed
Rasgon, N, McGuire, M, Tanavoli, S, Fairbanks, L, Rapkin, A. Neuroendocrine response to an intravenous l-tryptophan challenge in women with premenstrual syndrome. Fertil Steril 2000;73: 144–149.CrossRefGoogle Scholar
Nicolson, N, Storms, C, Ponds, R, Sulon, J. Salivary cortisol levels and stress reactivity in human aging. J Gerontol A Biol Sci Med Sci 1997;52: 68–75. CrossRefGoogle Scholar
Ansseau, M, Sulon, J, Doumont, A, Cerfontaine, JL, Legros, JJ, Sodoyez, JC, Demey-Ponsart, E. Use of saliva cortisol in the dexamethasone suppression test. Psychiatr Res 1984;13: 203–211. CrossRefGoogle ScholarPubMed
Lezak, MD. Neuropsychological assessment, 3rd edn. New York: Oxford University Press, 1995. Google ScholarPubMed
Luciana, M, Collins, PF, Depue, RA. Opposing roles for dopamine and serotonin in the modulation of human spatial working memory functions. Cereb Cortex 1998;8: 218–226.CrossRefGoogle ScholarPubMed
Riedel, WJ, Klaassen, T, Griez, E, Honig, A, Menheere, PPCA, Van Praag, HM. Dissociable hormonal, cognitive and mood responses to neuroendocrine challenge: evidence for receptor-specific serotonergic dysregulation in depressed mood. Neuropsychopharmacology 2002;26: 358–367.CrossRefGoogle ScholarPubMed
Kirschbaum, C, Wolf, OT, May, M, Wippich, W, Hellhammer, DH. Stress- and treatment-induced elevations of cortisol levels associated with impaired declarative memory in healthy adults. Life Sci 1996;58: 1475–1483.CrossRefGoogle ScholarPubMed
Newcomer, JW, Selke, G, Melson, AK, Hershey, T, Craft, S, Richards, K, Alderson, AL. Decreased memory performance in healthy humans induced by stress-level cortisol treatment. Arch Gen Psychiatry 1999;56: 527–533.CrossRefGoogle ScholarPubMed