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Optimal sampling for pedigree analysis: tracing a single gene

Published online by Cambridge University Press:  01 July 2016

E. A. Thompson
E. A. Thompson*
Affiliation:
University of Cambridge
*
∗Postal address: Statistical Laboratory, 16 Mill Lane, Cambridge, CB2 1SB, U.K.
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Abstract

In fitting genetic models on the basis of observations on an interrelated structure, sequential procedures can enhance efficiency. In this paper we consider the case of a rare gene segregating in a single large pedigree. The sampling rule is dictated by the effect of observations on the genotypic probability distribution of unobserved relatives; this effect is investigated.

Keywords

PEDIGREE ANALYSISGENETIC MODELSSEQUENTIAL TESTSDEPENDENT OBSERVATIONSPOSTERIOR PREDICTIONS
Type
Research Article
Information
Advances in Applied Probability , Volume 14 , Issue 4 , December 1982 , pp. 752 - 762
Copyright
Copyright © Applied Probability Trust 1982 

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References

[1] Cannings, C. and Thompson, E. A. (1977) Ascertainment in the sequential sampling of pedigrees. Clin. Genet. 12, 208–212.CrossRefGoogle ScholarPubMed
[2] Cannings, C., Thompson, E. A. and Skolnick, M. H. (1978) Probability functions on complex pedigrees. Adv. Appl. Prob. 10, 26–61.CrossRefGoogle Scholar
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[7] Thompson, E. A. (1981a) Optimal sampling for pedigree analysis; sequential schemes for sibships. Biometrics 37, 313–325.CrossRefGoogle ScholarPubMed
[8] Thompson, E. A. (1981b) Optimal sampling for pedigree analysis; relatives of affected probands. Amer. J. Hum. Genet. 33, 968–977.Google Scholar