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The Final State of an Epidemic in a Large Heterogeneous Population with a Large Initial Number of Infectives

Published online by Cambridge University Press:  01 July 2016

Steven M. Butler*
Affiliation:
University of Kentucky
*
* Postal address: Department of Statistics, 871 Patterson Office Tower, University of Kentucky, Lexington, KY 40506-0027, USA.

Abstract

We describe some asymptotic properties of a general S–I–R epidemic process in a large heterogeneous population. We assume that the infectives behave independently, that each infective has a generally distributed random number of contacts with the others in the population, and that among the initial susceptibles there is an arbitrary initial distribution of susceptibility. For the case of a large number of initial infectives, we demonstrate the asymptotic normality of the final size distribution as well as convergence of the final distribution of susceptibility as the population size approaches infinity. The relationship between the mean of the limiting final size distribution and the initial heterogeneity of susceptibility is explored, for a parametric example.

Type
General Applied Probability
Copyright
Copyright © Applied Probability Trust 1994 

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References

Bailey, N. T. J. (1975) The Mathematical Theory of Infectious Diseases and its Applications. Griffin, London.Google Scholar
Ball, F. (1983) The threshold behavior of epidemic models. J. Appl. Prob. 20, 227240.CrossRefGoogle Scholar
Ball, F. (1985) Deterministic and stochastic epidemics with several kinds of susceptibles. Adv. Appl. Prob. 17, 122.CrossRefGoogle Scholar
Becker, N. and Yip, P. (1989) Analysis of variations in an infection rate. Austral. J. Statist. 31, 4252.CrossRefGoogle Scholar
Billingsley, P. (1986) Probability and Measure. Wiley, New York.Google Scholar
Butler, S. M. (1994) Convergence results for an epidemic in a large heterogeneous population. Adv. Appl. Prob. (this issue).Google Scholar
Kendall, D. G. (1956) Deterministic and stochastic epidemics in closed populations. Proc. 3rd Berkeley Symp. Math. Statist. Probe 4, 149165.Google Scholar
Lefèvre, C. (1990) Stochastic epidemic models for S-I-R infectious diseases: a brief survey of the recent general theory. In Lecture Notes in Biomathematics 86, pp. 113. Springer-Verlag, Heidelberg.Google Scholar
Lefèvre, C. and Picard, Ph. (1989) On the formulation of discrete-time epidemic models. Math. Biosci. 95, 2735.CrossRefGoogle ScholarPubMed
Lefèvre, C. and Picard, Ph. (1990) The final size distribution of epidemics spread by infectives behaving independently. In Lecture Notes in Biomathematics 86, pp. 155169. Springer-Verlag, Heidelberg.Google Scholar
Ludwig, D. (1975) Final size distributions for epidemics. Math. Biosci. 23, 3346.Google Scholar
Martin-Löf, A. (1986) Symmetric sampling procedures, general epidemic processes and their threshold limit theorems. J. Appl. Prob. 23, 265282.Google Scholar
Picard, Ph. and Lefèvre, C. (1990) A unified analysis of the final size and severity distribution in collective Reed-Frost epidemic processes. Adv. Appl. Prob. 22, 269294.Google Scholar
Picard, Ph. and Levèvre, C. (1991) The dimension of Reed-Frost epidemic models with randomized susceptibility levels. Math. Biosci. 107, 225233.Google Scholar
Scalia-Tomba, G. (1985) Asymptotic final-size distribution for some chain-binomial processes. Adv. Appl. Prob. 17, 477495.Google Scholar
Scalia-Tomba, G. (1990) On the asymptotic final size distribution of epidemics in heterogeneous populations. Lecture Notes in Biomathematics 86, pp. 189196. Springer-Verlag, Heidelberg.Google Scholar
Sellke, T. (1983) On the asymptotic distribution of the size of a stochastic epidemic. J. Appl. Prob. 20, 390394.Google Scholar