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An Investigation of the Correlation Between Human Diseases and Trace Element Levels by Proton-Induced X-Ray Emission Analysis*

Published online by Cambridge University Press:  06 March 2019

R. D. Lear ,
H. A. Van Rinsvelt  and
W. R. Adams
R. D. Lear
Affiliation:
Department of Physics and Astronomy University of Florida Gainesville, Florida 32611
H. A. Van Rinsvelt
Affiliation:
Department of Physics and Astronomy University of Florida Gainesville, Florida 32611
W. R. Adams
Affiliation:
Department of Pathology, General Rose Memorial Hospital and University of Colorado Medical Center Denver, Colorado 80220
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Abstract

The proton beam from the 4 MV Van de Graaff at the University of Florida has been used in conjunction with a 5 mm thick lithium drifted silicon, Si (Li), x-ray detector to do elemental analysis of biomedical samples by proton-induced x-ray emission (PIXE). Several hundred samples, mostly autopsy organs ashed at high, temperature, have been analyzed by this method. The main object of the research is the correlation between human diseases and trace element levels. The target mass has been determined by monitoring the elastically scattered protons from the sample. This technique considerably reduces the target preparation time by eliminating careful weighings or doping of each individual sample.

Type
X-Ray Spectrometry in Biomedical Applications
Information
Advances in X-Ray Analysis , Volume 19: Twenty-Fourth Annual Conference on Applications of X-ray Analysis, August 6-8, 1975 , 1975 , pp. 521 - 532
Copyright
Copyright © International Centre for Diffraction Data 1975

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Footnotes

*

Supported in part by grants GM20281-01 and GM20282-01 from the National Institutes of Health.

References

1. Bearse, R. C., Close, D. A., Malanify, J. J. and Umbarger, C. J., “Elemental Analysis of Whole Blood Using Proton-Induced X-Ray Emission,” Analytical Chemistry 46,499–503 (1974).Google Scholar
2. Friberg, L. T., Piscator, M. and Nordberg, G. F., in Weast, R. C., Editor, Cadmium in the Environment, p. 55, CRC Press (1971).Google Scholar
3. Smythe, W. R., private communication.Google Scholar