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Some Biomedical Applications of Charged-Particle-Induced X-Ray Fluorescence Analysis

Published online by Cambridge University Press:  06 March 2019

J. L. Campbell ,
A. W. Herman ,
L. A. McNelles ,
B. H. Orr  and
R. A. Willoughby
J. L. Campbell
Affiliation:
University of Guelph, Guelph Ontario, N1G 2W1, Canada
A. W. Herman
Affiliation:
University of Guelph, Guelph Ontario, N1G 2W1, Canada
L. A. McNelles
Affiliation:
University of Guelph, Guelph Ontario, N1G 2W1, Canada
B. H. Orr
Affiliation:
University of Guelph, Guelph Ontario, N1G 2W1, Canada
R. A. Willoughby
Affiliation:
University of Guelph, Guelph Ontario, N1G 2W1, Canada
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Abstract

X-ray fluorescence induced by charged particles has been employed in trace element analysis of both animal and human blood, tissue and bone samples. Preparation techniques included microtome slicing and wet digestion in nitric acid, internal chemical standards being used in the latter case.

Most of the specimens arose from a study of interactions between the toxic elements lead and zinc in growing foals; this was motivated by reports of sickness and death in foals raised near lead-zinc smelters. The cause of toxicity in animals from environmental pollution is often attributed to Single factors, whereas in reality interactions among many factors, including a variety of toxic and nutrient trace elements, should be considered.

A variety of spectra are presented and elemental concentrations derived. Agreement between the X-ray data and atomic absorption spectrophotometry is encouraging. The results demonstrate the potential of particle-excited X-ray fluorescenee as a broad-range analytical technique for the study of trace element interactions.

Type
Research Article
Information
Advances in X-Ray Analysis , Volume 17: Twenty-Second Annual Conference on Applications of X-ray Analysis, August 22-24, 1973 , 1973 , pp. 457 - 466
Copyright
Copyright © International Centre for Diffraction Data 1973

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References

1. Kliwer, J.J., Kraushaar, J.J., Ristinen, R.A., Rudolph, H and Smythe, W.R., “Trace Element Analysis by Observation of Characteristic X-rays”, Bull. Am. Soc. 17, 545 (1972).Google Scholar
2. Cooper, J.A., “Comparison of Particle and Photon-excited X-ray Fluorescence applied to Trace Element Measurements of Environmental Samples”, Nucl. Instr. Meth. 106, 525–538 (1973).Google Scholar
3. Herman, A.W., McNelles, L.A. and Campbell, J.L., “Choice of Physical Parameters in Charged-particle-induced X-ray Fluorescence Analysis”, Int. J. App. Rad. in press.Google Scholar
4. Willoughby, R.A., MacDonald, E., McSherry, B.J. and Brown, G., “Lead and Zinc Poisoning and the Interaction between Lead and Zinc Poisoning in the Foal”, Can. J. Comp. Med. 36, 348–359 (1972)Google Scholar
5. Herman, A.W., McNelles, L.A. and Campbell, J.L., “Target Backings for Charged-particle-induced X-ray Fluorescence Analysis”, Nucl. Instr. Met. 109, 429–437 (1973).Google Scholar
6. Campbell, J.L., Herman, A.W., Orr, B.H. and McNelles, L.A., “Specimen Preparation and System Calibration in Proton-excited x-ray Fluorescence Analysis”, to be submitted for publication (1973).Google Scholar