Hostname: page-component-745bb68f8f-g4j75 Total loading time: 0 Render date: 2025-01-30T23:29:41.908Z Has data issue: false hasContentIssue false
  • English
  • Français

ABO Saliva and Plasma Agglutinins in Twins

Published online by Cambridge University Press:  27 January 2025

Sidia M. Callegari ,
F.M. Salzano  and
Heloisa F. Peña
Sidia M. Callegari
Affiliation:
Department of Genetics, Institute of Biosciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
F.M. Salzano*
Affiliation:
Department of Genetics, Institute of Biosciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
Heloisa F. Peña
Affiliation:
Department of Genetics, Institute of Biosciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
*
Departamento de Genética, Instituto de Biociências, Caixa Postal 1953, 90000 Porto Alegre, RS, Brazil

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The levels of ABO plasma agglutinins were studied in 47 MZ and 30 same-sex DZ pairs of twins having the same blood group. The degree of genetic determination of this characteristic, as ascertained by the comparison of average titers and titration scores, does not seem to be high; despite the fact that the correlation coefficients were always lower among DZ, the F ratio was significant in relation to the anti-B of A persons only. The presence of these antibodies was also investigated in the saliva of 30 MZ and 26 DZ pairs. Since about the same degree of discordance was observed among these two types of twins, the role of inheritance in the variability of this trait must be low.

Riassunto

Riassunto

I livelli delle agglutinine plasmatiche ABO sono stati studiati in 47 coppie di gemelli MZ ed in 30 coppie di gemelli DZ con lo stesso gruppo sanguigno. Il grado di determinazione genetica di tale caratteristica, cosi come accertato dai titoli medi e dai livelli di titolazione, non sembra essere elevato. Benché i coefficienti di correlazione fossero sempre più bassi nei gemelli DZ, il rapporto F è risultato significativo solo in relazione all'anti-B di individui A. La presenza di questi anticorpi è stata anche ricercata nella saliva di 30 coppie MZ e 26 DZ. Essendo stato riscontrato più o meno lo stesso grado di discordanza, il ruolo dell'eredità deve essere basso per questo carattere.

Résumé

Résumé

Les niveaux des agglutinines plasmatiques ABO ont été étudiés chez 47 couples de jumeaux MZ et 30 couples de jumeaux DZ avec le même groupe sanguin. Sur la base des titres moyens et des niveaux de titulation, le degré de détermination génétique de ce caractère ne semble pas être élevé. Quoique les coefficients de corrélation soient toujours inférieurs chez les jumeaux DZ, le rapport F n'est significatif qu'en relation à l'anti-B chez les sujets A. La présence de ces anticorps a aussi été recherchée dans la salive de 30 couples MZ et 26 DZ. Plus ou moins le même degré de discordance ayant été trouvé, le rôle de l'hérédité dans ce caractère doit être limité.

Zusammenfassung

Zusammenfassung

Bei 47 EZ- und bei 30 ZZ-Paaren gleicher Blutgruppe wurde der Gehalt an ABO-Agglutininen im Plasma untersucht. Nach den Durchschnittstitern und den Titrierungsniveaus zu urteilen, scheint die Erbbedingtheit dieses Merkmals nicht gross zu sein. Bei den ZZ waren die Korrelationskoeflfizienten zwar immer niedriger als bei den EZ, doch war das Verhältnis F nur bei A-Individuen in Bezug auf Anti-B wesentlich. Bei 30 EZ und 26 ZZ wurde auch der Speichel auf das Vorhandensein dieser Antikörper untersucht. Nachdem auch hierbei mehr oder weniger der gleiche Diskordanzgrad gefunden wurde, dürfte der Erbeinfluss auf dieses Merkmal gering sein.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 21 , Issue 4 , October 1972 , pp. 287 - 296
Copyright
Copyright © The International Society for Twin Studies 1978

References

REFERENCES

Bell, C.E. Jr., Fortwengler, H.P. 1971. Salivary anti-A and anti-B activity of group O males. Vox Sang., 21: 493–508.CrossRefGoogle ScholarPubMed
Boettcher, B. 1967. ABO blood group agglutinins in saliva. Acta Haematol. (Basel), 38: 351–360.CrossRefGoogle ScholarPubMed
Bühler, E. 1935. Untersuchungen über die Erblichkeit Isoagglutinintiters. Z. indukt. Abstam. Vererbungsl., 70: 463–467 (Cited by Furuhata and Matsunaga 1952).Google Scholar
Callegari, S.M., Salzano, F.M., Peña, H.F. 1972. ABH salivary secretion in twins. Acta Genet. Med. Gemellol., 21: 297–304.CrossRefGoogle ScholarPubMed
Claman, H.N., Merrill, D.A., Hartley, T.F. 1967. Salivary immunoglobulins: normal adult values and dissociation between serum and salivary levels. J. Allergy, 40: 151–159.CrossRefGoogle ScholarPubMed
Dahr, P. 1941. Serologische Untersuchungen bei 330 Zwillingspaaren. Z. Rassenphysiol., 12: 1–17.Google Scholar
Da Rocha, F.J., Salzano, F.M., Peña, H.F., Callegari, S.M. 1972. New studies on the heritability of anthropometric characteristics as ascertained from twins. Acta Genet. Med. Gemellol., 21: 125–134.CrossRefGoogle Scholar
Dunsford, I., Bowley, C.C. 1967. Techniques in Blood Grouping. Oliver and Boyd, Edinburgh (2nd ed.).Google Scholar
Furuhata, T., Matsunaga, E. 1952. Studies on the heredity of the group specific isoagglutinins in human normal serum. V. Heredity of the titers of isoagglutinin α and β. Proc. Jap. Acad., 28: 456–458.CrossRefGoogle Scholar
Furuhata, T., Nakamura, K., Nakajima, H., Suzuki, M. 1959. Studies on the Secretor (Type v) and Non-Secretor (Type V) of group specific agglutinin and their inheritance. Proc. Jap. Acad., 35: 105–107.CrossRefGoogle Scholar
Grundbacher, F.J. 1967. Quantity of hemolytic anti-A and anti-B in individuals of a human population: correlations with isoagglutinins and effects of the individual's age and sex. Z. Immunitaetsforsch., 134: 317–349.Google ScholarPubMed
Hummel, K., Schöch, J. 1967. Untersuchungen über die Ausscheidung von Anti-A und Anti-B- Hämagglutininen im menschlichen Mundspeichel. Z. Immunitaetsforsch., 133: 80–100.Google Scholar
Ichikawa, Y. 1959. A study of the iso-agglutinin titres in the sera of Australian subjects (White). Jap. J. Med. Sc. Biol., 12: 1–7.CrossRefGoogle ScholarPubMed
Jakobowicz, R., Graydon, J.J., Simmons, R.T. 1966. Observations on saliva agglutinins. Med. J. Aust., 1: 399–401.CrossRefGoogle ScholarPubMed
Kalff, M.W., Hijmans, W. 1969. Serum immunoglobulin levels in twins. Clin. Exp. Immunol., 5: 469–477.Google ScholarPubMed
Miyakoshi, H. 1951. The serological constitutions of men from the standpoint of iso-agglutinins in saliva. (In Japanese). Jap. J. Leg. Med., 5: 75–100.Google Scholar
Nebert, H. 1962. Über Anti-A1 und Anti-A2 im Speichel von Personen der Blutgruppe B. Med. Dissert., Martin-Luther-Universität, Halle.Google Scholar
Nijenhuis, L.E., Bratlie, K. 1962. ABO antibodies in twins. Vox Sang., 7: 236–238.Google ScholarPubMed
Otten, C.M. 1966. Non-genetic variations in salivary isoagglutinin titers. J. Dent. Res., 45: 1223.CrossRefGoogle ScholarPubMed
Otten, C.M. 1967. On pestilence, diet, natural selection, and the distribution of microbial and human blood group antigens and antibodies. Curr. Anthropol., 8: 209–226.CrossRefGoogle Scholar
Phansomboon, S. 1968. The incidence of anti-A and anti-B agglutinins in saliva of the Thai people. Vox Sang., 14: 396–399.Google ScholarPubMed
Prokop, O. 1961a. Untersuchungen über die Antikörper- Ausscheidung im Speichel. Lecture, Int. Akad. gerichtl. Medizin, Vienna (Cited by Prokop and Uhlenbruck 1969).Google Scholar
Prokop, O. 1961 b. Bemerkenswertes Überwiegen der Anti-B- Ausscheidung im Speichel von O-gegenüber A1-Trägern. Blut, 7: 143–148.CrossRefGoogle Scholar
Prokop, O., Uhlenbruck, G. 1969. Human Blood and Serum Groups. Maclaren and Sons, London.Google Scholar
Putkonen, T. 1932. Über die gruppenspezifischen Eigenschaften verschiedener Körperflüssigkeiten. Acta Soc. Med. Fenn. Duodecim. Ser. A, 14: 1–113 (Cited by Boettcher 1967).Google Scholar
Salzano, F.M. 1963. Blood groups and gene flow in Negroes from southern Brazil. Acta Genet. (Basel), 13: 9–20.Google ScholarPubMed
Salzano, F.M., Suñé, M.V., Ferlauto, M. 1967. New studies on the relationship between blood groups and leprosy. Acta Genet. (Basel), 17: 530–544.Google ScholarPubMed
Schmitz-Von Hülst, M., Clausnitzer, K.H. 1960. Über Blutgruppenagglutinine im Speichel. Z. Immunitaetsforsch. Exp. Therap., 119: 317–319.Google Scholar
Sondermeier, D., Flatow, H. 1962. Untersuchungen über die Isoantikörper im Speichel von O-Trägern. Z. Aerztl. Fortbild. (Jena), 56: 744–748.Google Scholar
Thomas, K. 1963. Untersuchungen über die Häufigkeit der Ausscheidung von Iso-Antikörpern im menschlichen Speichel bei 1120 Blutspendern aus der Bevölkerung von Dresden. Dtsch. Gesund-heitsw., 18: 554–559.Google Scholar
Wilson, R.M., Green, G.E. 1964. Genetic aspects of salivary secretion of isoagglutinins. Proc. Soc. Exp. Biol., 115: 982–985.CrossRefGoogle ScholarPubMed