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An Introduction to Genomic Imprinting and Parent of Origin Effects

Published online by Cambridge University Press:  01 August 2014

J.G. Hall  and
E. Lopez-Rangel
J.G. Hall*
Affiliation:
Department of Pediatrics, University of British Columbia and Children's Hospital, Vancouver, Canada
E. Lopez-Rangel
Affiliation:
Department of Pediatrics, University of British Columbia and Children's Hospital, Vancouver, Canada
*
Department of Pediatrics, University of British Columbia and Children's Hospital, 4480 Oak Street Room 2D 15, Vancouver, V6H 4V4, Canada

Extract

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Recent developments in molecular genetics and cytogenetics have allowed for better understanding of the inheritance and expression of genes. Many newly recognized mechanisms such as genomic imprinting, mosaicism, allelic expansion, cytoplasmic inheritance and uniparental disomy have been recognized to play an important role in human heredity.

Genomic imprinting refers to differences in the phenotype which are observed depending on whether the gene was inherited from the father or from the mother. Genomic imprinting is a difficult concept to understand because imprinting has been used loosely to refer to a number of different mechanisms including psychological development, endocrinological actions of cells and protein-protein interactions. Genomic imprinting produces parent-of-origin effects. Parent-of-origin effects is a term that encompasses many of the non-traditional types of inheritance and other genetic and non-genetic mechanisms which show an effect depending on whether they were paternally or maternally derived.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 45 , Issue 1-2 , April 1996 , pp. 59 - 61
Copyright
Copyright © The International Society for Twin Studies 1996

References

REFERENCES

1. Barlow, D: Imprinting: A gametes point of view. Trends Genet 1994; 10: 194–199.Google Scholar
2. Hall, JG: Genomic imprinting and it's clinical implications. New England J Med 1992; 328: 827–829.Google Scholar
3. Nicholls, RD: New insights reveal complex mechanisms involved in genomic imprinting. Am J Med Genet 1994; 54: 733–740.Google Scholar