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Blood Uric Acid Level and IQ: A Study in Twin Families

Published online by Cambridge University Press:  01 August 2014

E. Inouye ,
K.S. Park  and
A. Asaka
E. Inouye*
Affiliation:
Institute of Brain Research, University of Tokyo School of Medicine Institute for Developmental Research, Kasugai, Aichi, Japan
K.S. Park
Affiliation:
Sungshin Women's University, Seoul, Korea
A. Asaka
Affiliation:
Department of Mental Health, University of Tokyo School of Medicine
*
Institute for Developmental Research, Kamiyacho, Kasugai, Aichi 480-03, Japan

Abstract

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Applying newly devised model, heritability (VA/VP) of plasma uric acid level, corrected for age and sex and standardized, was estimated at 0.8 in families consisting of twin parents, spouses and children. Correlation between spouses due to common genotype (ρ) was approximately 0.1, and variance due to common familial environment (VEC/Vp) was -0.3. Analysis of families of selected twin children and their parents resulted in two estimates of heritability: approximately 0.7 and 0.3, ρ being 0.34 and 0.04, and VEC/Vp being 0.04 and 0.34, respectively. Regression of IQ (y) on corrected and standardized plasma uric acid level (x) in the twin children was y = 5.56x + 123, correlation being 0.334 (p < 0.025). The result indicates a genetic basis of blood uric acid level, which may have resulted from polymorphisms in purine metabolism pathway, end product of which is uric acid in man. The significant correlation between plasma uric acid level and IQ suggests a contribution of partly common gene loci to the two quantitative traits.

Keywords

Uric acidTwin familyHeritabilityAssortative matingCommon familial environmentIQ
Type
Twins and Mental Abilities
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 33 , Issue 2 , April 1984 , pp. 237 - 242
Copyright
Copyright © The International Society for Twin Studies 1984

References

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