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Breathing Patterns of Monozygous Twins during Behavioural Tasks

Published online by Cambridge University Press:  01 August 2014

S.A. Shea ,
T. Pham Dinh ,
R.D. Hamilton ,
A. Guz  and
G. Benchetrit
S.A. Shea*
Affiliation:
Physiology Program, Harvard School of Public Health, Boston, USA
T. Pham Dinh
Affiliation:
Laboratoire d'Informatique et de Mathematiques Appliques de Grenoble, France
R.D. Hamilton
Affiliation:
Department of Medicine, Charing Cross and Westminster Medical School, London, UK
A. Guz
Affiliation:
Department of Medicine, Charing Cross and Westminster Medical School, London, UK
G. Benchetrit
Affiliation:
Laboratoire de Physiologie, Faculte de Medecine de Grenoble, France
*
Physiology Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA

Abstract

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To better understand behavioural and genetic influences upon breathing, the breathing patterns of 8 pairs of monozygous (MZ) twins were measured under 4 behavioural conditions; relaxed without standardisation; eyes closed; eyes open; and reading. Breathing was quantified by inspiratory and expiratory durations (TI, TE), tidal volume (VT) and derived variables. Airflow shape was normalised and quantified using 8 dimensions. Reading caused breathing to increase by > 500 ml/min compared to the other four conditions. Differences in breathing between combinations of two conditions were compared by testing whether the differences within an individual were smaller than the differences between random pairs of individuals from the same 16 subjects. For almost all respiratory variables, and whatever the behavioural condition, there were highly significant similarities within an individual (p < 0.00025 on 32/80 comparisons). Under each condition, the differences within MZ twin-pairs were compared to the differences within random-pairs from the same subject population. There were highly significant similarities within twin-pairs for the airflow shape across all conditions. However, TI, TE and VT failed to consistently show significant similarities within twin pairs. Hence, an individual's airflow shape appears to be a fundamental characteristic which is conserved when behavioural condition and level of ventilation changes. Further, MZ twins have similar airflow shapes – whatever the behavioural situation. Hence, behavioural influences upon airflow shape act upon monozygous twin pairs in similar ways, or such influences were negligible under the conditions of the present study.

Keywords

BreathingStatisticsBehaviourMental tasksVentilation
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 42 , Issue 2 , April 1993 , pp. 171 - 184
Copyright
Copyright © The International Society for Twin Studies 1993

References

REFERENCES

1.Arkinstall, WW, Nirmel, K, Klissouras, V, Milic-Emili, J (1974): Genetic differences in the ventilatory response to inhaled CO2. J Appl Physiol 36:6–11.Google Scholar
2.Asmussen, E (1977): Regulation of respiration: “The Black Box”. Acta Physiol Scand 99:85–90.Google Scholar
3.Bachy, JP, Eberhard, A, Baconnier, P, Benchetrit, G (1986): A program for cycle-by-cycle analysis of biological rhythms. Application to respiratory rhythm. Comp Meth Prog Biomed 23:297–307.Google Scholar
4.Benchetrit, G, Baconnier, P, Demongeot, J, Pham Dinh, T (1987): Flow profile analysis of human breathing at rest. In Benchetrit, G (ed): Concepts and Formalizations in the Control of Breathing. Manchester, Manchester University Press, pp. 207–216.Google Scholar
5.Benchetrit, G, Shea, SA, Pham Dinh, T, Bodocco, S, Baconnier, P, Guz, A (1989): Individuality of breathing patterns in adults assessed over time. Respir Physiol 75:199–210.CrossRefGoogle ScholarPubMed
6.Collins, DD, Scoggin, CH, Zwillich, CW, Weil, JV (1978): Hereditary aspects of decreased hypoxic response. J Clin Invest 62: 105–110.CrossRefGoogle ScholarPubMed
7.Cotes, JE (1979): Lung Function. Assessment and Application in Medicine (4th Ed) Oxford: Blackwell Scientific Publications.Google ScholarPubMed
8.Eisele, JH, Wuyam, B, Savourey, G, Eterradossi, J, Bittel, JH, Benchetrit, G (1992): Individuality, of breathing patterns during hypoxia and exercise. J Appl Physiol 72:2446–2453.Google Scholar
9.Kawakami, Y, Irie, T, Shida, A, Yoshikawa, T (1982a): Familial factors affecting arterial blood gas values and respiratory chemosensitivity in chronic obstructive pulmonary disease. Am Rev Respir Dis 125:420–425.Google ScholarPubMed
10.Kawakami, Y, Yoshikawa, T, Shida, A, Asanuma, Y, Murao, M (1982b): Control of breathing in young twins. J Appl Physiol 52:537–542.CrossRefGoogle ScholarPubMed
11.Kawakami, Y, Yamamoto, H, Yoshikawa, T, Shida, A (1984): Chemical and behavioural control of breathing in adult twins. Am Rev Respir Dis 129:703–707.Google Scholar
12.Kawakami, Y, Yamamoto, H, Yoshikawa, T, Shida, A (1985a): Age-related variation in respiratory chemonsensitivity in monozygotic twins. Am Rev Respir Dis 132:89–92.Google Scholar
13.Kawakami, Y, Shida, A, Yamamoto, H, Yoshikawa, T (1985b): Pattern of genetic influence on pulmonary function. Chest 87:507–511.CrossRefGoogle ScholarPubMed
14.Kawakami, Y, Kusaka, H, Nishimura, M, Abe, S (1986): Trachea and lung dimensions in nonsmoking twins: morphological and functional studies. J Appl Physiol 61:495–499.Google Scholar
15.Mahalanobis, PC (1936): On the generalised distance in statistics. Proc Nat Inst Sci India 12:49–55.Google Scholar
16.Mountain, R, Zwillich, C, Weil, J (1978): Hypoventilation in obstructive lung disease. The role of familial factors. New Engl J Med 298:521–525.CrossRefGoogle ScholarPubMed
17.Redline, S, Tishler, PV, Lewitter, FI, Tager, IB, Munoz, A, Speizer, FE (1987): Assessment of genetic and nongenetic influences on pulmonary function. Am Rev Respir Dis 135:217–222.Google Scholar
18.Saunders, NA, Leeder, SR, Rebuck, AS (1976): Ventilatory response to carbon dioxide in young athletes: a family study. Am Rev Respir Dis 113:497–502.Google ScholarPubMed
19.Shea, SA, Walter, J, Murphy, K, Guz, A (1987a): Evidence for individuality of breathing patterns in resting healthy man. Respir Physiol 68:331–344.Google Scholar
20.Shea, SA, Walter, J, Pelley, C, Murphy, K, Guz, A (1987b): The effect of visual and auditory stimuli upon resting ventilation in man. Respir Physiol 68:345–357.Google Scholar
21.Shea, SA, Murphy, K, Hamilton, R, Benchetrit, G, Guz, A (1988): Do the changes in respiratory pattern and ventilation seen with different behavioural situations reflect metabolic demands? In von Euler, C, Katz-Salamon, M (eds): Respiratory Psychophysiology, Wenner-Gren International Symposium Series, Vol. 50; Basingstoke: MacMillan Press, pp. 21–28.Google Scholar
22.Shea, SA, Benchetrit, G, Pham Dinh, T, Hamilton, RD, Guz, A (1989): The breathing patterns of identical twins. Respir Physiol 75:211–224.CrossRefGoogle ScholarPubMed
23.Shea, SA, Guz, A (1992): Personnalité ventilatoire — an overview. Respir Physiol 87:275–291.CrossRefGoogle ScholarPubMed
24.Snedecor, GW, Cochran, WG (1980): Statistical Methods (7th ed). Iowa: Iowa State University Press.Google Scholar