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Chronon and the Problem of Anticipation (On two family cases of diabetes)

Published online by Cambridge University Press:  01 August 2014

L. Gedda ,
D. Casa  and
G. Brenci
L. Gedda
Affiliation:
Istituto di Genetica Medica e Gemellologia«G. Mendel», Roma
D. Casa
Affiliation:
Istituto di Genetica Medica e Gemellologia«G. Mendel», Roma
G. Brenci
Affiliation:
Istituto di Genetica Medica e Gemellologia«G. Mendel», Roma

Summary

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The Authors analyze the phenomenon whereby, in progressing from generation to generation, a hereditary disease may appear at an earlier, equal or later age (anticipation, repetition or posticipation, respectively). They believe that this represents the phenotypic effect of a temporal dimension of the gene, the “chronon”, which may reveal stability, plus-variance or minus-variance according to the standard genetic models. This interpretation provides an explanation of two family cases of diabetes mellitus, respectively exhibiting anticipation and posticipation, and repetition.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 16 , Issue 3 , July 1967 , pp. 217 - 228
Copyright
Copyright © The International Society for Twin Studies 1967

References

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