Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-10T13:51:45.023Z Has data issue: false hasContentIssue false
  • English
  • Français

Congenital Anomalies in Twins in Northern Ireland. III: Anomalies of the Cardiovascular System, 1974-1978

Published online by Cambridge University Press:  01 August 2014

J. Little  and
N.C. Nevin
J. Little*
Affiliation:
Department of Community Medicine and Epidemiology, University of Nottingham, England
N.C. Nevin
Affiliation:
Department of Medical Genetics, Queen's University of Belfast, Northern Ireland
*
Department of Community Medicine and Epidemiology, The University of Nottingham Medical School, Queen's Medical Centre, Nottingham NG7 2UH, UK

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Rates of congenital anomalies of the cardiovascular system were compared between twins and singletons in a population-based study in Northern Ireland during the period 1974-1978. Multiple sources of ascertainment were used. As in previous studies, the rate of anomalies of the cardiovascular system in twins (91.0/10,000) was higher than the rate in singletons (66.4/10,000). The excess was confined to twins from pairs of like sex and, in the main, anomalies of the circulatory system other than of the heart itself were involved. Problems in the interpretation of this excess are discussed. No twins were concordant for congenital cardiovascular anomalies of any type.

Keywords

Congenital anomaliesCardiovascular diseaseTwinningAscertainment
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 38 , Issue 1-2 , April 1989 , pp. 27 - 35
Copyright
Copyright © The International Society for Twin Studies 1989

References

REFERENCES

1. Anderson, RC (1976): Fetal and infant death, twinning, and cardiac malformations in families of 2000 children with and 500 without cardiac defcts. Am J Cardiol 38: 218–224.Google Scholar
2. Anderson, RC (1977): Congenital cardiac malformations in 109 sets of twins and triplets. An J Cardiol 39: 1045–1050.Google Scholar
3. British Paediatric Association (1969): The Cardiff Diagnostic Classification: Codes Designed for Use in Paediatric Departiments. Cardiff: British Paediatric Association.Google Scholar
4. Bryan, E, Little, J, Burn, J (1987): Congenital anomalies in twins. In Rodeck, CH (ed): Fetal Diagnosis of Genetic Defects. London: Balliere's Clinical Obstetrics and Gynaecology, Vol 1, pp 697–721.Google Scholar
5. Burn, J, Corney, G (1984): Congenital heart defects and twinning. Acta Genet Med Gemellol 33: 61–69.Google Scholar
6. Cameron, AH, Edwards, JH, Derom, R, Thiery, M, Boelaert, R (1983): The value of twin surveys in the study of malformations. Europ J Obstet Gynec Reprod Biol 14: 347–356.Google Scholar
7. Campbell, M (1961): Twins and congenital heart disease. Acta Genet Med Gemellol 10: 443–455.CrossRefGoogle ScholarPubMed
8. Hay, S, Wehrung, DA (1970): Congenital malformations in twins. Am J Hum Genet 22: 662–678.Google Scholar
9. Information Services Division (1974): Cardiff Diagnostic Classification Perinatal Supplement, Revised edition (Scotland). Edinburgh: Common Services Agency.Google Scholar
10. Kallen, B (1986): Congenital malformations in twins: a population study. Acta Genet Med Gemellol 35: 167–178.Google Scholar
11. Kenna, AP, Smithells, RW, Fielding, DW (1975): Congenital heart disease in Liverpool. Quart J Med 44: 17–44.Google Scholar
12. Layde, PM, Erickson, D, Falek, A, McCarthy, BJ (1980): Congenital malformations in twins. Am J Hum Genet 32: 69–78.Google Scholar
13. Little, J (1987): Congenital anomalies in twins. Paper presented at the International Workshop on Twin Pregnancies, Gent, October 1987.Google Scholar
14. Little, J, Bryan, E (1986): Congenital anomalies in twins. Seminars in Perinatology 10: 50–64.Google Scholar
15. Little, J, Bryan, E (1988): Congenital anomalies. In MacGillivray, I, Thompson, B, Campbell, DM (eds): Twinning and Twins. London: Wiley, pp 207–240.Google Scholar
16. Little, J, Nevin, NC (1989): Congenital anomalies in twins in Northern Ireland. I. Anomalies in general and specific anomalies other than neural tube defects and of the cardiovascular system, 1974-1979, Acta Genet Med Gemellol 38: 1–16.Google Scholar
17. McKeown, T, Record, RG (1960): Malformations in a population observed for five years after birth. In Wolstenholme, GEW, O'Connor, CM (eds): CIBA Foundation Symposium on Congenital Malformations. London: Churchill, pp 2–21.Google Scholar
18. Mitchell, SC, Korones, SB, Berendes, HW (1971): Congenital heart disease in 56,109 births: incidence and natural history. Circulation 43: 323–332.Google Scholar
19. Mitchell, SC, Sellman, AH, Westphal, MC, Park, J (1971): Etiologic correlates in a study of congenital heart disease in 56109 births. Am J Cardiol 28: 653–657.Google Scholar
20. Myrianthopoulos, NC (1975): Congenital malformations in twins. Birth Defects Orig Art Ser XI: 1–39.Google Scholar
21. Pexieder, T, De Wals, P, Bein, G, Bosi, G, Stoll, C, Gallez, A, Houston, A, Vliers, A, Wilkinson, J, (1987): Preliminary results of the sub-project for the registration and follow-up of congenital heart disease. In De Wals, P, Lechat, MF (eds): EUROCAT Report 2: Surveillance of Congenital Anomalies, Years 1980-1984. Brussels: Catholic University of Louvain, pp 211–227.Google Scholar
22. Richards, MR, Merritt, KK, Samuels, MH, Langmann, AG (1955): Congenital malformations of the cardiovascular system in a series of 6053 infants. Pediatrics 12: 12–32.Google Scholar
23. Uchida, IA, Rowe, RD (1957): Discordant heart anomalies in twins. Am J Hum Genet 9: 133–140.Google Scholar
24. Windham, GC, Bjerkedal, T (1984): Malformations in twins and their siblings, Norway, 1967-1979. Acta Genet Med Gemellol 33: 87–95.Google Scholar
25. World Health Organization (1967): International Classification of Diseases, 8th revision. Geneva: World Health Organization.Google Scholar