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Cytogenetic Study of Otosclerosis

Published online by Cambridge University Press:  01 August 2014

J. François ,
M. T. Matton-Van Leuven  and
P. Kluyskens
J. François
Affiliation:
Dept. of Ophthalmology, Div. of Medical Genetics
M. T. Matton-Van Leuven
Affiliation:
University of Ghent (Belgium)
P. Kluyskens
Affiliation:
Dept. of Oto-rhino-laryngology

Summary

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Chromosomal evaluation was done in 62 patients affected with otosclerosis, clinically and surgically proven. Numerical and structural karyotype analysis of leucocyte and fibroblast cultures, showed normal results.

Cytogenetic findings published earlier by other authors in a small series of otosclerosis patients and where mosaicism in the D-group was detected, are contradicted.

The importance of the critical evaluation of the cytogenetic method used and of the necessity to investigate cytogenetically a large enough number of patients, before linking a clinical and phenotypical condition to cytogenetic finding, is stressed.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 16 , Issue 2 , April 1967 , pp. 124 - 158
Copyright
Copyright © The International Society for Twin Studies 1967

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