Hostname: page-component-cd9895bd7-7cvxr Total loading time: 0 Render date: 2024-12-28T01:05:59.241Z Has data issue: false hasContentIssue false

Discordant Monozygotic Twins with Trisomy 13

Published online by Cambridge University Press:  01 August 2014

H.T. Loevy*
Affiliation:
Departments of Pediatric Dentistry, Ophthalmology and Pediatrics, University of Illinois at Chicago
Marilyn Miller
Affiliation:
Departments of Pediatric Dentistry, Ophthalmology and Pediatrics, University of Illinois at Chicago
Ira M. Rosenthal
Affiliation:
Departments of Pediatric Dentistry, Ophthalmology and Pediatrics, University of Illinois at Chicago
*
College of Dentistry, University of Illinois, 801 South Paulina, Chicago, IL 60612, USA

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Monozygotic twins with typical trisomy 13 are reported. Despite an identical karyotype, the twins were dimorphic for the presence of an omphalocele. Reasons for the rarity of MZ twins with trisomy 13 are presented. It is suggested that the presence of a chromosomal abnormality in MZ twins may predispose to dimorphism.

Type
Case Report
Copyright
Copyright © The International Society for Twin Studies 1985

References

REFERENCES

1. Allen, G, Baroff, GS (1955): Mongoloid twins and their siblings. Acta Genet 5: 294326.Google ScholarPubMed
2. Bencini, MA (1952): Contributo clinico allo studio del mongolismo nei gemelli: presentazione di una coppia di gemelle monozigotiche. Acta Genet Med Gemellol I: 2939.CrossRefGoogle Scholar
3. Hata, A, Suzuki, Y, Matsui, I, Kuroki, Y (1982): Ring 18 mosaicism in identical twins. Hum Genet 62:364367.CrossRefGoogle ScholarPubMed
4. Hustinx, TWJ, Eberle, P, Geertz, SJ, Brink, JT, Woltring, LM (1961): Mongoloid twins with 48 chromosomes (AA+A21XXY). Ann Human Genet 25:111115.CrossRefGoogle Scholar
5. Jervis, GA (1943): Mongolism in twins. Am J Ment Defic 47: 364369.Google Scholar
6. Keay, AJ (1958): The significance of twins in mongolism in the light of new evidence. J Ment Defic Res 2:17.Google ScholarPubMed
7. Kelly, TE (1980): Clinical genetics and genetic counseling. Yearbook Med Pub, Chicago.Google Scholar
8. Liberfarb, RM, Atkins, L, Holmes, LB (1978): Down syndrome in two of three triplets. Clin Genet 14:261264.Google Scholar
9. Lipovetzkaya, NG (1964): A case of Down's disease in both uniovular twins. Pediatriia 43:102103.Google Scholar
10. McDonald, AD (1964): Mongolism in twins. J Med Genet 1:3941.Google Scholar
11. Mikkelsen, M, Melchior, JC (1962): Mongoloid twins with trisomy of chromosome No. 21. Acta Genet (Base 1) 12:164171.Google Scholar
12. Myrianthopoulos, NC (1975): Congenital malformations in twins, epidemiological survey. New York, Stratton Intercontinental Med. Book Corp.Google Scholar
13. Nance, WE, Uchida, I (1964): Turner's syndrome, twinning and an unusual variant of glucose-6-phosphate dehydrogenese. Am J Human Genet 16:380392.Google Scholar
14. Oster, J (1953): Mongolism. A clinicogenealogical investigation comprising 526 mongols living in Seeland and neighbouring islands in Denmark. Copenhagen, Danish Science Press.Google Scholar
15. Papp, Z (1975): Monozygotic twins with concordance for Down's syndrome and congenital heart disease. Acta Genet Med Gemellol 24:4146.Google Scholar
16. Rasore-Quartino, A (1967): Gemelli MZ con mongolismo concordante. Acta Genet Med Gemellol 16:395401.CrossRefGoogle Scholar
17. Reyes, PG, Hsu, LYF, Strauss, L, Rose, J, Hirschhorn, K (1978): Trisomy 8 mosaicism syndrome. Report of monozygotic twins. Clin Genet 14:9097.Google Scholar
18. Shapiro, LR, Farnsworth, PG (1972): Down's syndrome in twins. Clin Genet 3:364370.CrossRefGoogle ScholarPubMed
19. Shiono, H, Kasahara, S (1971): Genet studies on twins of Down's syndrome with 47-chromosomes. Tohoku J Exp Med 105:309316.CrossRefGoogle Scholar
20. Telfer, MA, Baker, D, Bergman, M (1972): Twins, probably monozygotic, displaying Down's syndrome, physical and functional mirror-imaging, and discordance for congenital heart disease. Am J Ment Defic 76:391396.Google Scholar
21. Wolff, E de, Scharer, K, Lejeune, J (1962): Contribution a l'étude des jumeaux mongoliens. Un cas de monozygotisme hétérocaryote Helv Paediat Acta 17:301328.Google Scholar
22. Young, RJ (1954): Mongolism in both of monozygotic twins. Arch Dis Child 29:5559.Google Scholar
23. Zellweger, H (1968): Familial aggregates of the 21-trisomy syndrome. Ann NY Acad Sci 155:784792.CrossRefGoogle Scholar