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Genetic Variance and Heritability of Cardiovascular Risk Factors in Chinese Adolescent Twins

Published online by Cambridge University Press:  01 August 2014

C.J. Chen ,
B.H. Cohen ,
E.L. Diamond ,
T.M. Lin  and
J.S. Chen
C.J. Chen*
Affiliation:
Institute of Public Health, National Taiwan University College of Medicine, Taipei, Taiwan
B.H. Cohen
Affiliation:
Department of Epidemiology, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland
E.L. Diamond
Affiliation:
Department of Epidemiology, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland
T.M. Lin
Affiliation:
Institute of Public Health, National Taiwan University College of Medicine, Taipei, Taiwan
J.S. Chen
Affiliation:
Department of Clinical Pathology, National Taiwan University Hospital, Taipei, Taiwan
*
Institute of Public Health, National Taiwan University College of Medicine, Taipei, Taiwan100

Abstract

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In order to estimate genetic variance and heritability of systolic blood pressure (SBP), diastolic blood pressure (DBP), serum cholesterol and triglyceride levels, a total of 235 (79 male and 82 female MZ, 41 male and 33 female DZ) twin pairs, recruited from 12 junior high schools in Taipei city, were studied. Statistically significant genetic variance observed for SBP, DBP, serum cholesterol and triglycerides persisted after adjustment for age and anthropometric characteristics. However, further adjustment for dietary preference, beverage consumption, and other host and environmental factors gave different results: genetic variance of adjusted SBP and DBP was still significant, while significance was found only in males for cholesterol and in neither males nor females for triglycerides. Heritability estimates of unadjusted SBP, DBP, cholesterol and triglycerides were 0.27, 0.45, 0.21 and 0.41, respectively, for males, and 0.15, 0.42, 0.41 and 0.82, respectively, for females. After adjustment for age, anthropometric characteristics, host and environmental factors, the heritability estimates of SBP, DBP and cholesterol were 0.64, 0.72 and 0.50, respectively, for males, and 0.40, 0.60 and 0.37, respectively, for females.

Keywords

Blood pressureCholesterolTriglyceridesHeritabilityAdolescent twins
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 33 , Issue 3 , July 1984 , pp. 363 - 373
Copyright
Copyright © The International Society for Twin Studies 1984

References

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