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Genetic Variance and Heritability of Serum Cholesterol and Triglycerides Among Chinese Twin Neonates

Published online by Cambridge University Press:  01 August 2014

C.-J. Chen ,
M.-W. Yu ,
C.-J. Wang ,
S.-L. Tong ,
M. Tien ,
T.-Y. Lee ,
H.-C. Lue ,
F.-Y. Huang ,
C.-C. Lan  and
K.-H. Yang
...Show all authors
C.-J. Chen*
Affiliation:
Institute of Public Health, National Taiwan University College of Medicine, Taiwan, Republic of China
M.-W. Yu
Affiliation:
Institute of Public Health, National Taiwan University College of Medicine, Taiwan, Republic of China
C.-J. Wang
Affiliation:
Institute of Public Health, National Taiwan University College of Medicine, Taiwan, Republic of China
S.-L. Tong
Affiliation:
Institute of Public Health, National Taiwan University College of Medicine, Taiwan, Republic of China
M. Tien
Affiliation:
Institute of Public Health, National Taiwan University College of Medicine, Taiwan, Republic of China
T.-Y. Lee
Affiliation:
National Taiwan University Hospital, Taiwan, Republic of China
H.-C. Lue
Affiliation:
National Taiwan University Hospital, Taiwan, Republic of China
F.-Y. Huang
Affiliation:
Mckay Memorial Hospital, Taiwan, Republic of China
C.-C. Lan
Affiliation:
Mckay Memorial Hospital, Taiwan, Republic of China
K.-H. Yang
Affiliation:
Taipei Municipal Maternal and Child Hospital, Taiwan, Republic of China
H.-C. Wang
Affiliation:
Taipei Municipal Maternal and Child Hospital, Taiwan, Republic of China
H.-Y. Shin
Affiliation:
National Nursing School Hospital, Taipei, Taiwan, Republic of China
C.-Y. Liu
Affiliation:
National Nursing School Hospital, Taipei, Taiwan, Republic of China
J.-S. Chen
Affiliation:
National Taiwan University Hospital, Taiwan, Republic of China
*
Institute of Public Health, National Taiwan University College of Medicine, 1, Jen-Ai Road Section 1, Taipei 10018, Taiwan, Republic of China

Abstract

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In order to examine the genetic variance and heritability of serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides, a total of 349 pairs of same-sexed twin neonates born in four major general teaching hospitals in Taipei City were studied. Based on the placental pattern and 12 red blood cell antigens, 271 monozygotic (MZ) and 78 dizygotic (DZ) twin pairs were identified. There was a significant genetic variance for total cholesterol, HDL-C, LDL-C, and triglycerides both unadjusted and adjusted for sex, gestational age and placentation. The unadjusted heritability of total cholesterol, HDL-C, LDL-C, and triglycerides was 0.59, 0.30, 0.25 and 0.75, respectively; while the corresponding adjusted heritability was 0.74, 0.38, 0.31, and 0.49, respectively. Intrapair variance of serum lipids was not significantly different between monochorionic and dichorionic MZ twins.

Keywords

HeritabilitySerum lipidsNeonatesTwins
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 39 , Issue 1 , January 1990 , pp. 123 - 131
Copyright
Copyright © The International Society for Twin Studies 1990

References

REFERENCES

1.Berg, K (1981): Twin research in coronary heart disease. In Gedda, L, Parisi, P, Nance, WE (eds): Twin Research 3: Part C, Epidemiology and Clinical Studies. New York: Alan R Liss, pp 117.Google Scholar
2.Chen, CJ, Cohen, BH, Diamond, EL, et al (1984): Genetic variance and heritability of cardiovascular risk factors in Chinese adolescent twins. Acta Genet Med Gemellol 33:363.Google Scholar
3.Chen, CJ, Lin, TM, Chang, C, et al (1987): Epidemiological characteristics of twinning rates in Taiwan. Acta Genet Med Gemellol 36:335.Google ScholarPubMed
4.Christian, JC (1979): Testing twin means and estimating genetic variance: basic methodology for the analysis of quantitative twin data. Acta Genet Med Gemellol 28:35.Google Scholar
5.Corey, LA, Kang, KW, Christian, JC, et al (1976): Effects of chorion type on variation in cord blood cholesterol of monozygotic twins. Am J Hum Genet 28:433.Google Scholar
6.Daccini Dal Colleto, GM, Krieger, H, Magalhaes, JR (1981): Estimates of genetic and environmental determinants of serum lipid and lipoprotein concentrations in Brazilian twins. Hum Hered 31:132.Google Scholar
7.Department of Health, Executive Yuan, Republic of China (1987): Health statistics. II. Vital statistics. Taipei: Department of Health.Google Scholar
8.Falconer, DS (1960): Quantitative genetics. New York: Ronald.Google Scholar
9.Garrison, RJ, Castelli, WP, Feinleib, M, et al (1979): The association of total cholesterol, triglycerides and plasma lipoprotein cholesterol levels in first degree relatives and spouse pairs. Am J Epidemiol 110:313.Google Scholar
10.Haseman, JK, Elston, RC (1970): The estimation of genetic variance from twin data. Behav Genet 1:11.CrossRefGoogle ScholarPubMed
11.Hewitt, D, Milner, J, Breckenridge, C, et al (1976): A twin study on the heritability of lipoprotein fractions. Acta Genet Med Gemellol 25:150.Google Scholar
12.Kempthorne, O, Osborne, RH (1961): The interpretation of twin data. Am J Hum Genet 13:320.Google ScholarPubMed
13.Martin, AO, Kurczynski, TW, Steinberg, AG (1973): Familial studies of medical and anthropometric variables in a human isolate. Am J Hum Genet 25:584.Google Scholar
14.McMillan, GC (1973): Development of arteriosclerosis. Am J Cardiol 32:542.CrossRefGoogle Scholar
15.Orchard, TJ, Rodgers, M, Hedley, AJ, et al (1981): Serum lipids in a teenage population. Geographic, seasonal and familial factors. Int J Epidemiol 10:161.CrossRefGoogle Scholar
16.Shear, CL, Frerichs, RR, Weinberg, R, et al (1978): Childhood sibling aggregation of coronary artery disease risk factor variables in a biracial community. Am J Epidemiol 107:522.CrossRefGoogle Scholar
17.Sing, CF, Orr, JD (1978): Analysis of genetic and environemtnal sources of variation in serum cholesterol in Tecumseh, Michigan. IV. Separation of polygene from common environment effects. Am J Hum Genet 30:491.Google Scholar
18.US National Institute of Health (1974): Manual of laboratory operations of the Lipid Research Clinics Programs. Lipids and lipoprotein analysis. Washington, DC: Govemment Printing Office (DHEW Publication No. (NIH) 75-628).Google Scholar
19.Weinberg, R, Avet, LM, Gardner, MJ (1976): Estimates of the heritability of serum lipoprotein and lipid concentrations. Clin Genet 9:588.Google Scholar