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Inbreeding Load in the Newborn of Hyderabad

Published online by Cambridge University Press:  27 January 2025

J.S. Murty  and
Talat Jamil
J.S. Murty*
Affiliation:
Human Genetics Section, Department of Genetics, Osmania University, Hyderabad, India
Talat Jamil
Affiliation:
Human Genetics Section, Department of Genetics, Osmania University, Hyderabad, India
*
Department of Genetics, Osmania University, Hyderabad-7, India

Summary

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The population of Andhra Pradesh has been considered ideal for the study of inbreeding effects in view of its high incidence of consanguinity. Information for the present investigation was obtained from 1,091 consecutive hospital single births to study the genetic load in the newborn in terms of mortality and malformation as a consequence of inbreeding. The nature of consanguinity was examined and the frequency of uncle-niece marriages was found to be lower than in other parts of Andhra Pradesh. The mortality load in the newborn was found to be two lethal equivalents per individual, while the malformation load at birth was half the mortality load.

Riassunto

Riassunto

La popolazione dell'Andhra Pradesh è stata considerata ideale per lo studio degli effetti dell'endogamia, data la sua elevata incidenza di consanguineità. I dati per l'attuale ricerca sono stati ricavati dall'ospedale di Hyderabad, dove un campione di 1091 nascite semplici consecutive sono state rilevate in modo da studiare il carico genetico sui neonati in termini di mortalità e malformazioni come conseguenza dell'endogamia. La natura della consanguineità è stata esaminata e la frequenza di matrimoni zio-nipote è risultata inferiore che in altre parti dell'Andhra Pradesh. Il carico della mortalità nei neonati è risultato di due geni-equivalenti letali per individuo, mentre il carico delle malformazioni alla nascita è risultato della metà.

Résumé

Résumé

La population de l'Andhra Pradesh a été considérée idéale pour l'étude des effets de l'endogamie, étant donnée sa fréquence élevée de consanguinité. Les données pour cette recherche ont été obtenues de l'hôpital d'Hyderabad, où un échantillon de 1091 naissances simples consécutives a été considéré afin d'y étudier le poids génétique en termes de mortalité et malformations en conséquence de l'endogamie. La nature de la consanguinité a été examinée et la fréquence de marriages oncle-nièce a été trouvée inférieure à celle d'autres régions de l'Andhra Pradesh. Le poids de la mortalité des nouveaux-nés est de deux gènes-équivalents léthaux pour individus, alors que celui des malformations est de la moitié.

Zusammenfassung

Zusammenfassung

Ihrer hohen Blutsverwandtschaftsrate wegen eignet sich die Bevölkerung des Andhra Pradesh besonders zum Studium der Inzuchtswirkung. Um den Erbeinfluss der Inzucht auf die Sterblichkeit und die Missbildungen der Neugeborenen zu untersuchen, wurden im Hospital zu Hyderabad Erhebungen an einem Muster von 1091 hintereinander erfolgten Einzelgeburten vorgenommen. Es wurde dabei der Grad der Blutsverwandtschaft untersucht, u. es zeigte sich, dass Onkel-Nichten-Ehen weniger zahlreich waren als in anderen Gegenden des Andhra Pradesh. Der Einfluss der Neugeborenensterblichkeit entspricht zwei letalen-äquivalent-Genen pro Person; die Missbildungen bei Geburt hingegen betragen die Hälfte.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 21 , Issue 4 , October 1972 , pp. 327 - 331
Copyright
Copyright © The International Society for Twin Studies 1972

References

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