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Incidence of Handicaps in Multiple Births and Associated Factors

Published online by Cambridge University Press:  01 August 2014

Y. Yokoyama ,
T. Shimizu  and
K. Hayakawa
Y. Yokoyama
Affiliation:
Department of Public Health, Kinki University School of Medicine, Osaka, Japan
T. Shimizu
Affiliation:
Department of Public Health, Kinki University School of Medicine, Osaka, Japan
K. Hayakawa
Affiliation:
Department of Community Health Nursing, Osaka University Faculty of Medicine, Osaka, Japan

Abstract

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This study investigated the degree of risk of handicap in twins, triplets, quadruplets and quintuplets and associated factors, and examined the clustering tendency of handicaps. The sample was recruited from the Kinki University Twin and Higher Order Multiple Birth Registry. This panel consisted of 705 pairs of twins (1410 twins), 96 sets of triplets (287 triplets excluding 1 infant death), 7 sets of quadruplets (27 quadruplets excluding 1 infant death), and 2 sets of quintuplets (10 quintuplets), all of whom were born after 1977. The incidence of handicap was 3.7% in twins, 8.7% in triplets, 11.1% in quadruplets, and 10.0% in quintuplets. The risk of prodicing at least 1 handicapped child was approximately 1 in 13 pairs of twins (7.4%), 1 in 4 or 5 sets of triplets (21.6%), and 1 in 2 sets of quadruplet and quintuplets (50%). There was a significantly higher clustering tendency of handicaps in twins and triplets compared with the expected frequency calculated from the incidence rate of handicap. Four significant risk factors for subsequent handicap were found by logistic regression: gestation number, shortening of gestational age, premature rupture of the membrane, and toxemia during pregnancy.

Keywords

Multiple birthHandicapClustering tendencyGestational agePremature rupture of the membraneToxemia during pregnancy
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 44 , Issue 2 , April 1995 , pp. 81 - 91
Copyright
Copyright © The International Society for Twin Studies 1995

References

REFERENCES

1.Acien, P, Lloret, G, Lloret, M (1990): Perinatal morbidity and mortality in pregnancy hypertensive disorders: prognostic value of clinical and laboratory findings. Int J Gynaecol Obstet 32: 229–35.CrossRefGoogle ScholarPubMed
2.Asher, P, Schonell, FE (1950): A surve. A Survey of 400 cases of cerebral palsy in childhood. Arch Dis Child 25: 360–79.CrossRefGoogle Scholar
3.Botting, BJ, Davies, IM, Macfarlance, AJ (1987): Recent trends in the incidence of multiple births and associated mortality. Arch Dis Child 62: 941–50.CrossRefGoogle ScholarPubMed
4.Botting, BJ, Macfarlance, AJ, Price, FV (1990): Three, four and more: a study of triplet and higher order births. London: HMSO, pp 59–97.Google Scholar
5.Bryan, EM (1983): The loss of a twin. Maternal and Child Health 8: 201–6.Google Scholar
6.Grutzner-Konnecke, H, Grutzner, P, Grutzner, B, Grutzner, U, Spalding-Grutzner, A, Spalding, P (1990): Higher-order multiple births: natural wonder or failure of therapy? Acta Genet Med Gemellol 39: 491–495.Google ScholarPubMed
7.Hoist, K, Andersen, E, Philip, J, Henningsen, I (1989): Antenatal and perinatal conditions correlated to handicap among 4-year-old children. Am J Perinatol 6: 258–267.Google Scholar
8.Illingworth, RS, Woods, GE (1960): The incidence of twins in cerebral palsy and mental retardation. Arch Dis Child 35: 333–5.Google Scholar
9.Imaizumi, Y, Inoue, E (1982): Analysis of multiple birth rates in Japan IV. Quadruplet birth and stillbirth rates. Jpn J Human Genet 27: 227–234.CrossRefGoogle Scholar
10.Imaizumi, Y (1992): Twinning rates in Japan. Acta Genet Med Gemellol 41: 165–175.Google ScholarPubMed
11.Imaizumi, Y, Inoue, E (1979): Analysis of multiple birth rates in Japan. Acta Genet Med Gemellol 28: 107–124.Google ScholarPubMed
12.Imaizumi, Y (1982): Sex ratio of triplet births in Japan. Hum Hered 32: 114–120.Google Scholar
13.Imaizumi, Y, Inoue, E, Asaka, A (1981): Mortality rate of Japanese twins. Social Biology 28: 176–186.Google ScholarPubMed
14.Imaizumi, Y, Inoue, E, Asaka, A (1981): Mortality rate of Japanese twins and triplets III. Infant deaths of triplets after birth to one year of age. Acta Genet Med Gemellol 30: 281–284.Google Scholar
15.Imaizumi, Y, Inoue, E (1982): Analysis of multiple birth rates in Japan IV. Quadruplets: birth and stillbirth rates. Jpn J Human Genet 27: 227–234.Google Scholar
16.Imaizumi, Y (1993): Trends in the incidence of multiple births in Japan. J Health and Welfare statistics 40 (6): 3–8.Google Scholar
17.Kiely, JL, Kleinman, JC, Kiely, M (1992): Triplets and higher-order multiple births: time trends and infant mortality. Am J Dis Child 146: 862·8.Google Scholar
18.Lang, JM, Cohen, A, Lieberman, E (1992): Risk factors for small-for-gestational-age birth in a preterm population. Am J Obstet Gynecol 166: 1374–8.CrossRefGoogle Scholar
19.Levene, MJ, Wild, J, Steer, P (1992): Higher multiple births and the modern management of infertility in Britain. Br J Obstet Gynaecol 99: 607–13.Google Scholar
20.Luke, B, Keith, LG (1992): The contribution of singletons, twins and triplets to low birthweight, infant mortality and handicap in the United States. J Reprod Med 37: 661–6.Google Scholar
21.MacGillivray, I, Campbell, D M, Thompson, B (1988): Twinning and twins. Great Britain: John Wiley & Sons, pp 111–142.Google Scholar
22.McDonald, AD (1963): Cerebral palsy in children of very low birthweight. Arch Dis Child 38: 579–88.CrossRefGoogle Scholar
23.Newman, RB, Jones, JS, Miller, MC (1991): Influence of clinical variables on triplet birth-weight. Acta Genet Med Gemellol 40: 173–179.Google Scholar
24.Petterson, B, Nelson, KB, Watson, L, Stanley, F (1993): Twins, triplets and cerebral palsy in births in Western Australia in the 1980s. BMJ 307: 1239–1243.Google Scholar
25.Russel, EM (1961): Cerebral palsied twins. Arch Dis Child 36: 328–36.Google Scholar
26.Stanley, FJ (1979): An epidemiological study of cerebral palsy in Western Australia, 1956-1975. I Changes in total incidence of cerebral palsy and associated factors. Devel Med Child Neurol 21: 701–13.CrossRefGoogle ScholarPubMed
27.Scheller, JM, Nelson, KB (1992): Twinning and neurologic morbidity. Am J Dis Child 146: 1110–3.Google Scholar
28.Yokoyama, Y, Shimizu, T, Hayakawa, K (1995): Prevalence of cerebral palsy in twins, triplets, and quadruplets, Int J Epidemiology (in print).Google Scholar
29.Yokoyama, Y, Shimizu, T, Hayakawa, K (1995): Maternal partial attachment for one of a pair of twins and the influence of childcaring environments. Jpn J Public Health 40: 106–111.Google Scholar
30.Yokoyama, Y, Shimizu, T, Hayakawa, K (1995): Antenatal complications in triplet pregnancies and birthweights of triplets compared with twins. Jpn J Public Health 42: 113–120.Google Scholar
31.Yokoyama, Y, Shimizu, T, Hayakawa, K (1995): Childcare problems in twin and triplet families and maternal fatigue symptoms. Jpn J Public Health 42: 187–193.Google Scholar
32.Yokoyama, Y, Shimizu, T, and Hayakawa, K (1995): Handicap in twins and triplets. Jpn J Hygiene 49: 1013–1018.Google Scholar